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Immunology

Image: Preliminary Predictive Criteria Identified For COVID-19 Cytokine Storm (Photo courtesy of University of L’Aquila).

Preliminary Predictive Criteria Identified for COVID-19 Cytokine Storm

While most of cases of COVID-19 are mild, a sizeable number of patients develop a severe acute hyperimmune response characterized by a cytokine storm (CS). Two forms of CS, hemophagocytic lymphohistiocytosis (HLH) and macrophage activation syndrome (MAS), rely on well-established criteria to identify their occurrence. More...
05 Jan 2021
Image: Oncuria is a simple urine test that detects and analyzes multiple tumor protein biomarkers for improved bladder cancer detection (Photo courtesy of Nonagen Bioscience Corporation).

Multiplex Bead-Based Immunoassay Validated for Non-Invasive Bladder Cancer Detection

Cancer of the urinary bladder has two unique features: the tumor is continuously immersed in a urine and the tumor is able to shed cells or release tumor associated products (e.g., protein, DNA, RNA) directly into urine, which is easily collected and assessed. More...
04 Jan 2021
Image: STEMvision: Automated and standardized colony counting for the hematopoietic colony-forming unit (CFU) assay (Photo courtesy of STEMCELL Technologies).

Chronic Lymphocytic Leukemia Increases Peripheral Blood Hematopoietic Stem Cells

Chronic lymphocytic leukemia (CLL) is an indolent B-cell malignancy invariably infiltrating the bone marrow. The disease remains incurable, and after emergence of therapy, resistant disease patients succumb to infections because of secondary bone marrow failure. More...
31 Dec 2020
Image: The IMMAGE 800 protein chemistry analyzer (Photo courtesy of Beckman Coulter).

Novel Biomarkers Predict the Development of Incident Heart Failure

 Heart failure (HF), caused by abnormal cardiac structure and function, represents the end stage of several cardiac diseases, and significantly worsens both quality of life and life expectancy with a five year survival rate of approximately 50%. Lifetime risk of the development of HF is 20% and overall prevalence 2%. More...
30 Dec 2020
Image: Schematic diagram of Osteopontin Links Myeloid Activation and Disease Progression in Systemic Sclerosis (FVC=forced vital capacity) (Photo courtesy of University of Michigan).

Osteopontin Linked to Progressive Lung Scarring in Scleroderma Patients

Systemic sclerosis (SSc) is an autoimmune disease characterized by a distinct pathogenic triad of microvascular damage, dysregulation of innate and adaptive immunity, and fibrosis involving skin and many internal organs, such as the heart, kidney, and lungs. More...
28 Dec 2020
Image: Orientia tsutsugamushi present in the liquid scraped from the abdominal wall of an infected mouse. The abdominal walls of the infected mouse were fixed and stained with Giemsa stain and presence of O. tsutsugamushi particles (purple particles) detected by light microscopy (Photo courtesy of University of Illinois, Urbana-Champaign).

Scrub Typhus Enzyme Linked Immunoassay Evaluated for Accuracy

Scrub typhus is a rickettsial infection caused by a mite-borne bacterium, Orientia tsutsugamushi. It is primarily transmitted to humans through bites of infected trombiculid mite larvae, also known as chiggers. More...
28 Dec 2020
Image: The Alinity i is a compact, immunoassay system that can reliably be used to diagnose infectious diseases (Photo courtesy of Abbott Laboratories).

Newly Developed Immunoassay Evaluated for Infectious Diseases

Although a diagnosis of infectious diseases is essential for timely treatment, the performance of diagnostic tests has been hardly evaluated due to variable results that are influenced by multiple factors in different conditions. More...
23 Dec 2020
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The Immunology channel of LabMedica deals with diagnostic techniques and immuonassays such as ELISA, pregnancy tests, immunoblotting, immunohistochemical staining, serology, and associated hardware.
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