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Molecular Diagnostics

Image: An artist\'s depiction of the operating principle of single-molecule sequencing (Photo courtesy of Osaka University).

Current-Tunneling Measurements Analyze Single DNA Molecules

A team of Japanese genomics researchers has devised a method for cancer diagnosis, which is based on the analysis of single molecules of DNA without the need for chemical modification or amplification. More...
09 Jul 2018
Image: A Western blot analysis of vCJD prions obtained after amplification by protein misfolding cyclic amplification (PMCA) of cerebrospinal fluid (CSF) from two patients with vCJD (MM and MV) and three control patients and a crude reference brain homogenate from a vCJD patient (Photo courtesy of Etablissement Français du Sang).

Variant CJD Diagnosed by Protein Misfolding Amplification

Variant Creutzfeldt-Jakob disease (vCJD) is a neurodegenerative infectious disease caused by transmission of a cattle prion disease (bovine spongiform encephalopathy) to humans. Most vCJD cases have occurred in the United Kingdom, where an estimated 1 in 2,000 persons is potentially asymptomatically infected. More...
06 Jul 2018
Image: The HiSeq 2000 sequencing platform (Photo courtesy of Illumina).

Recurrent Rearrangements Identified in Soft Tissue Tumors

A new genomic and transcriptomic analysis of rare, soft tissue tumors that develop in infants has detected recurrent specific gene rearrangements that may render them responsive to targeted treatment. More...
06 Jul 2018
Image: Neuromyelitis optica (NMO) is an autoimmune disease and a potentially fatal disease in which the immune system attacks cells in the optic nerve and spinal cord. Aquaporin-4–immunoglobulin G (AQP4-IgG) is the specific biomarker for NMO spectrum disorders and most accurately diagnosed using a cell-based blood test (Photo courtesy of Mayo Clinic Laboratories).

DNA Code Unraveled for Rare Neurologic Disease

Neuromyelitis optica (NMO) is a potentially fatal disease in which the immune system attacks cells in the optic nerve and spinal cord, leaving some patients blind and/or paralyzed. More...
04 Jul 2018

Measurement of Two Biomarkers Predicts Diabetes Risk

Results presented in a recently published study indicated that it is possible to predict likelihood of developing diabetes by measuring the levels of two biomarkers in a single blood sample. More...
03 Jul 2018
Image: Multiple bacilli (rod-shaped bacteria, here shown as black and bean-shaped) shown between white blood cells in urinary microscopy. These changes are indicative of a urinary tract infection (Photo courtesy of Wikimedia Commons).

UTIs Diagnosed with Genetic Analysis of Cell-Free DNA

Genetic analysis of cell-free DNA (cfDNA) in urine samples reveals valuable information, which enables comprehensive monitoring of host and pathogen dynamics in bacterial and viral urinary tract infections. More...
03 Jul 2018
Image: Rheumatoid arthritis can cause a range of debilitating symptoms, including pain and swelling in the joints, tiredness and depression (Photo courtesy of SPL).

Gene Signatures and Biomarkers Predict RA Onset

Rheumatoid arthritis is characterized by joint inflammation leading to destruction of bone and cartilage. Since structural joint damage is irreversible, early recognition and treatment is a key focus in an effort to halt the progression of the disease. More...
28 Jun 2018
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Genetic Testing channel of LabMedica brings the latest in molecular genetics, cytogenetics, and epigenetics, and methods from PCR to FISH, and more.
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