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Molecular Diagnostics

Image: The Guardant360 kit for biopsy-free tissue sequencing for cancer (Photo courtesy of Guardant Health).

Liquid Biopsy Tests Identified Cell-Free Tumor DNA Mutations

The feasibility of using cell-free circulating tumor DNA (ctDNA) next-generation sequencing (NGS) from liquid biopsies as a complement or alternative to tissue NGS has been evaluated. More...
20 Oct 2016
Image: A histopathology of non-alcoholic steatohepatitis (NASH) in a liver biopsy (Photo courtesy of SPL).

Simple Blood Test Vastly Improves Severe Liver Disease Detection

A new non-invasive method of predicting the risk of developing a severe form of liver disease could ensure patients receive early and potentially life-saving medical intervention before irreversible damage is done. More...
19 Oct 2016
Image: A diagram of mechanisms of RNA-Mediated DNA Rearrangement. (A) Chimeric RNAs act as repair templates for double-strand DNA breakage. (B) Chimeric RNAs act as scaffolds to bring two genomic loci into proximity, which might promote breakage and fusion between the two gene loci (Photo courtesy of the University of Virginia).

Strange Chimeras Defy Scientific Understanding of Human Genetics

The human genome is far more complex than thought, with genes functioning in an unexpected fashion that scientists have wrongly assumed must indicate cancer as gene fusions and their encoded products fusion ribonucleic acids (RNAs) and proteins are viewed as one of the hallmarks of cancer. More...
18 Oct 2016
Image: Sanger sequencing – a sequence ladder by radioactive sequencing compared to fluorescent peaks (Photo courtesy of Dr. Abizar Lakdawalla).

New Genetic Links Identified for Heart Disease Risk Factors

Genetics have been implicated in cardiovascular and blood diseases for some time, however as these are complex diseases, it is extremely difficult to find specific genetic causes, but large scale genomic datasets can be used to help identify potential novel biological targets for studying cardiovascular and other diseases. More...
14 Oct 2016
Image: A suitcase laboratory used for Chikungunya virus (CHIKV) diagnosis in the field (Photo courtesy of Ahmed Abd El Wahed).

Field Test Allows Rapid Diagnosis of Chikungunya Virus Infection

Chikungunya virus (CHIKV) infection causes symptoms that are similar to Dengue and Zika as well as other viral diseases, including influenza and accurate diagnosis of CHIKV is important for effective outbreak responses, including patient management and mosquito control. More...
12 Oct 2016
Image: A formulated custom TaqMan array card (Photo courtesy of Thermo Fisher Scientific).

Quantitative Molecular Diagnostic Methods Identify Causes of Childhood Diarrhea

The number of cases of childhood diarrhea attributed to pathogens such as bacteria, parasites, viruses or other infections has been substantially underestimated and may be nearly twice as high as previous analysis suggests. More...
06 Oct 2016
Image: The Prolaris assay measures how fast the cells in the prostate tumor are dividing (Photo courtesy of Myriad Genetics).

Genomic Fingerprinting Helps Predict Prostate Tumor Aggressiveness

Next-generation sequencing is revealing genomic heterogeneity in localized prostate cancer (CaP), but incomplete sampling of CaP multiclonality has limited the implications for molecular subtyping, stratification, and systemic treatment. More...
06 Oct 2016
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Genetic Testing channel of LabMedica brings the latest in molecular genetics, cytogenetics, and epigenetics, and methods from PCR to FISH, and more.