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Molecular Diagnostics

Image: A histopathology of classic Mycosis fungoides. This skin biopsy specimen demonstrates an atypical lymphocytic infiltrate going up into the epidermis (epidermotropism) in the absence of epidermal edema (spongiosis). The collection of atypical lymphocytes surrounding a Langerhans cell is a Pautrier microabcess, the hallmark of classic MF (Photo courtesy of the University of Pennsylvania).

Tool Predicts Deadly Form of Mycosis Fungoides

Mycosis fungoides (MF), the most common cutaneous T cell lymphoma (CTCL) is a malignancy of skin-tropic memory T cells. Most MF cases present as early stage (stage I A/B, limited to the skin), and these patients typically have a chronic, indolent clinical course. More...
21 May 2018
Image: The RainDrop digital PCR system (Photo courtesy of RainDance Technologies).

Factors Affecting Plasma DNA Analysis Evaluated

There is vast potential in precision-medicine methods of both detecting and monitoring disease by looking for indications of cancer mutations in cell-free DNA (cfDNA), circulating in the blood. However, there are many factors that can significantly alter these samples as they are collected and analyzed. More...
21 May 2018
Image: The Genedrive HCV ID kit is a qualitative assay providing results in 90 minutes in a decentralized environment (Photo courtesy of Genedrive).

Near-Patient Hepatitis C Assay Validated

Chronic infection with hepatitis C virus (HCV) is a major public health problem, estimated to infect 1.0% of the world’s population (71 million people) and to be responsible for 400, 000 annual deaths as a result of cirrhosis and liver cancer. More...
17 May 2018
Image: The MSI Analysis System, Version 1.2, is a fluorescent multiplex PCR-based method to detect microsatellite instability (MSI), a form of genomic instability (Photo courtesy of Promega).

Molecular Subtype Identified for CRCs Metastasized to Liver

Metastases are the leading cause of cancer-related deaths and frequently are widely disseminated, which has led to the prevailing view that metastases are always widespread. More...
17 May 2018
Image: The Infinium CoreExome-24 Kit – a DNA microarray kit that delivers genome-wide SNP and genetic variant information for genetic studies, especially large-scale human genotyping studies (Photo courtesy of Illumina).

Familial Genetics Influence Migraine Type

Familial aggregation in chronic diseases is well known but its background is not well understood. Migraine is an example of a common disease that can aggregate in families. It is one of the most common brain disorders worldwide, affecting approximately 15% to 20% of the adult population in developed countries. More...
16 May 2018
Image: The MiSeq bench-top sequencer (Photo courtesy of Illumina).

Kidney Disease Patient Urine Contains Diverse Bacteria

Bacterial communities in the bladders of men and women without clinical urinary tract infections (UTI) have been discovered and emerging studies suggests that the urinary microbiome may influence bladder health. More...
15 May 2018
Image: Islet of Langerhans from the pancreas of a patient with chronic type 1 diabetes of 19 years duration. A single lobe of the pancreas was found to contain islets rich in residual beta cells (alpha cells in red; beta cells in green) (Photo courtesy of Diapedia).

Genetic Scores Stratify Risk of Developing Type 1 Diabetes

Approximately 0.3% of newborns will develop autoimmunity to pancreatic beta cells in childhood and subsequently develop type 1 diabetes before adulthood. Primary prevention of type 1 diabetes will require early intervention in genetically at-risk infants. More...
15 May 2018
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Genetic Testing channel of LabMedica brings the latest in molecular genetics, cytogenetics, and epigenetics, and methods from PCR to FISH, and more.