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Molecular Diagnostics

Image: Sensitivity of the loop-mediated isothermal amplification (LAMP) assay for the detection of Clonorchis sinensis eggs in feces experimentally spiked with a known number of eggs in ten-fold serial dilutions from 10,000 eggs (lane 1) to one egg (lane 5) (Photo courtesy of Seoul National University Medical Research Center).

LAMP Assay Detects Clonorchiasis in Human Samples

Clonorchiasis is prevalent in the Far East, and a major health problem in endemic areas. Infected persons may experience, if not treated, serious complications such as bile stone formation, pyogenic cholangitis, and even cholangiocarcinoma. More...
26 Oct 2017
Image: Trypanosoma cruzi amastigotes in heart tissue from a patient with Chagas disease (Photo courtesy of the CDC).

Next-Generation Immunoassay Developed for Chagas Diseases

Chagas disease, caused by the protozoan Trypanosoma cruzi, is a major health and economic problem in Latin America for which no vaccine or appropriate drugs for large-scale public health interventions are yet available. More...
26 Oct 2017
Image: A pipette machine allows the scientists in the Karius laboratory to process blood samples within one day (Photo courtesy of Hamilton).

Novel Blood Test Identifies Pathogens in Suspected Sepsis

A diagnostic test that can accurately identify the cause of sepsis is important to determine the most effective and appropriate antimicrobial therapy; however, a causative pathogen is not always identified in a large percentage of sepsis cases. More...
26 Oct 2017
Image: Whole genome genotyping arrays are an important tool for discovering variants that contribute to human disease (Photo courtesy of Megan Smolenyak, MBA).

New Genetic Risk Factors Identified for Peanut Allergy

Peanut allergy develops in early life and is rarely outgrown. Roughly 1% of Canadian adults and between 2% and 3% of Canadian children are affected, and the symptoms can be severe and even life threatening. More...
25 Oct 2017
Image: The HiSeq X Ten sequencing system (Photo courtesy of Illumina).

Whole Genome Sequencing Identifies New Autism Signature

Current genetic tests for autism scan broad portions of the genome for DNA insertions or deletions that have previously been linked to autism. Other tests look for changes in the DNA building blocks of certain genes, but these tests flag only about 10% to 30% of cases. More...
25 Oct 2017
Image: The Affymetrix Axiom CEU Genome-Wide Population-Optimized Human Arrays are genotyping panels that offer genetic coverage of rare and common variants for genome-wide disease association studies (Photo courtesy of Thermo Fisher Scientific).

New Risk Variants Identified for Restless Legs Syndrome

As many as one in ten people of European ancestry is affected by restless legs syndrome, in which sufferers feel an overwhelming urge to move, often in conjunction with unpleasant sensations, usually in the legs. More...
24 Oct 2017
Image: An ocular fundus aspect of retinoblastoma (Photo courtesy of Wikimedia).

Liquid Biopsy for Retinoblastoma Discovered

A new study indicates a proof-of-concept for a safe and effective way to derive genetic profile information from a retinoblastoma tumor without removing the eye. More...
24 Oct 2017
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Genetic Testing channel of LabMedica brings the latest in molecular genetics, cytogenetics, and epigenetics, and methods from PCR to FISH, and more.
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