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Molecular Diagnostics

Image: An ancient bacterial enzyme (grey) crawls along a tangled strand of RNA (orange), creating a complimentary strand of DNA (blue). This enzyme, called GsI-IIC RT, and part of a group of enzymes known as TGIRTs, have novel properties that make it easier to detect RNA biomarkers from cancer and other disorders (Photo courtesy of the University of Texas at Austin).

Enzyme Boosts Power of Liquid Biopsies to Detect Cancers

A new tool has been developed for liquid biopsy that can detect RNA biomarkers from cancer cells in a patient's blood much more accurately and completely than other existing methods. This could soon provide doctors with a more complete picture of an individual's disease. More...
29 Nov 2017
Image: A histopathology of a brain showing metastatic lesions from a patient with non-small cell lung cancer (Photo courtesy of Peter Anderson).

CSF Analyzed in Lung Cancer with Brain Metastases

The analysis of mutations in cerebrospinal fluid of lung cancer patients with brain metastases has been explored. Tumor tissue from brain metastasis is difficult to obtain and therefore less invasive methods are needed to identify and monitor the presence of known actionable mutations. More...
29 Nov 2017
Image: Sample application for a VeriStrat assay. The assay provides highly sensitive results in 72 hours for non-small cell lung cancer (NSCLC) patients (Photo courtesy of Biodesix).

Automated RNA Extraction from Plasma Analytically Validated

A novel, automated method for extracting circulating RNA from plasma has been demonstrated and the method performed equivalently or better than the established manual method that is currently used. More...
28 Nov 2017
Image: A histopathology of extensive hepatocyte necrosis seen here in a case of paracetamol overdose. The hepatocytes at the right are dead, and those at the left are dying. This pattern can be seen with a variety of hepatotoxins (Photo courtesy of the University of Utah Medical School).

Test Detects Overdose Patients at Risk of Liver Damage

Paracetamol is a safe analgesic drug when taken at therapeutic doses; however, in overdose, paracetamol is hepatotoxic and is the most common cause of acute liver failure in the USA and Europe. More...
28 Nov 2017
Image: Diagram of DiviTum sTK1 assay: BrdUTP is subsequently incorporated into a solid-phase DNA-strand. Incorporated BrdU is detected using an anti-BrdU monoclonal antibody conjugated to the signal generating enzyme alkaline phosphatase. The level of BrdU incorporated over time is proportional to the level of thymidine kinase activity in the sample (Photo courtesy of Biovica).

Blood Test Reduces Interim for Evaluating Cancer Treatment

Although prognosis and treatment of metastatic breast cancer (MBC) have improved over the last years, there is still an unmet clinical need for more precise prognostic and treatment monitoring tools. More...
27 Nov 2017
Image: A recent study suggests clues taken from small molecules in saliva may be able to help diagnose and predict the duration of concussions in children (Photo courtesy of Penn State University College of Medicine).

MicroRNA Panel Detects Concussion Symptoms in Children

A panel of microRNAs has been shown to be a potent biomarker for the detection of prolonged concussion symptoms in children. More...
27 Nov 2017
Image: A CPK model of the oxytocin molecule (Photo courtesy of Wikimedia Commons).

Microfluidic Platform Devised for Determination of Autism Biomarker

A team of Polish scientists has devised a unique electrochemical microfluidic platform for determination of the autism biomarker oxytocin. More...
27 Nov 2017
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