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Molecular Diagnostics

Image: (A) Histology of a case of olfactory neuroblastoma with upregulation of CD24 gene by microarray, (B) confirmed by CD24 protein overexpression in the tumor cells (Photo courtesy of Caris Life Sciences).

Analysis Offers Treatment Options for Olfactory Neuroblastoma

Olfactory neuroblastoma (ONB) is a rare, locally aggressive, malignant neoplasm originating in the olfactory epithelium in the nasal vault. The recurrence rate of ONB remains high and there are no specific treatment guidelines for recurrent/metastatic ONBs. More...
01 Feb 2018
Image: Histopathology: (D) H&E staining showing the trabecular pattern of MAFA mutation-positive insulinomas. (E) Immunostaining shows diffuse MAFA expression in the tumor, at lower levels compared with the neighboring normal islets strongly expressing MAFA (Inset) (Photo courtesy of the Queen Mary University of London).

Mutation Found in Families with Contradictory Blood Sugars

Insulinomatosis is a condition characterized by the occurrence of multicentric insulinomas, pancreatic neuroendocrine tumors with β-cell–like features causing hyperinsulinemic hypoglycemia. More...
01 Feb 2018
Image: The BD FACS CANTO II multiparameter flow cytometer (Photo courtesy of BD Biosciences).

Genetic Mutation Linked to Crohn's and Parkinson's Diseases

The inflammatory bowel diseases (IBD) are composed of two major subtypes, Crohn’s disease (CD) and ulcerative colitis (UC), which are distinguished by the distribution of chronic inflammatory changes. More...
31 Jan 2018
Image: The diagnostic accuracy of the HostDx Sepsis assay compared to other methods (Photo courtesy of Inflammatix).

Immune Response Tests Enable Rapid Antibiotic Decisions

A novel test uses quantitative multiplex gene expression to analyze a patient's immune system, or the host response, rather than looking for the presence of a pathogen that indicates whether there is an infection in the blood. More...
31 Jan 2018
Image: The FDA-approved BRACAnalysis CDx test as a companion diagnostic (Photo courtesy of Myriad Genetics).

Lab-Developed Tests Compared with Approved Diagnostics

The debate about the role of the government-approved diagnostics in the regulation of laboratory-developed tests (LDTs) has focused attention on the analytical performance of all clinical laboratory testing. More...
30 Jan 2018
Image: A diagram of the loss of an androgen-inactivating and isoform-specific HSD17B4 splice form enables emergence of castration-resistant prostate cancer (Photo courtesy of the Lerner Research Institute).

New Gene Variant Linked to Prostate Cancer

Prostate cancer (PCa) is the most commonly diagnosed malignancy and the second leading cause of cancer-related death in men in the USA. The growth and survival of PCa cells are driven by androgens through activation of the androgen receptor (AR) and its target genes. More...
30 Jan 2018
Image: CancerSEEK multi-analyte test simultaneously evaluates levels of eight cancer proteins and the presence of cancer gene mutations from circulating DNA in the blood (Photo courtesy of Elizabeth Cook and Kaitlin Lindsay, Johns Hopkins University).

Liquid Biopsy Test Detects Eight Types of Cancer

Cancer researchers have developed a "liquid biopsy" blood test that can detect eight common cancer types through assessment of the levels of circulating proteins and mutations in cell-free DNA. More...
29 Jan 2018
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Genetic Testing channel of LabMedica brings the latest in molecular genetics, cytogenetics, and epigenetics, and methods from PCR to FISH, and more.
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