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Molecular Diagnostics

Image: A bone marrow smear of a patient with Acute Myeloid Leukemia; dysplastic changes are noted in both the granulocytic and erythroid lineages (Photo courtesy of Peter Maslak).

Acute Myeloid Leukemia Regulatory Networks Identified

Adult acute myeloid leukemia (AML) is a type of cancer in which the bone marrow makes abnormal myeloblasts (a type of white blood cell), red blood cells, or platelets. AML is a heterogeneous disease caused by a variety of alterations in transcription factors, epigenetic regulators and signaling molecules. More...
28 Nov 2018
Image: The Chromium Single Cell Gene Expression Solution provides high-throughput, single cell expression measurements that enable discovery of gene expression dynamics and molecular profiling of individual cell types (Photo courtesy of 10X Genomics).

Pregnancy-Related Immune Changes Revealed by Placenta Sequencing

A team of scientists has used single-cell RNA sequencing to map expression profiles in the placenta, focusing on the decidua tissue that forms from the lining of the uterus and placental trophoblast tissue from the fetus that interacts with maternal cells. More...
28 Nov 2018
Image: The ability to detect cell-free circulating tumor DNA in blood provides the opportunity to develop non-invasive tests to measure tumor burden and detect molecular signatures in tumors that are associated with resistance to therapy (Photo courtesy of Huntsman Cancer Institute).

Sensitive Tumor Detection Uses Cell-Free DNA Methylomes

A combination of "liquid biopsy," epigenetic alterations and machine learning has been used to develop a blood test to detect and classify cancer at its earliest stages. The method holds promise of being able to find cancer earlier when it is more easily treated and long before symptoms ever appear. More...
27 Nov 2018
Image: The Quant-iT high sensitivity PicoGreen double-stranded DNA Assay Kit (Photo courtesy of Invitrogen).

Biomarker Found for Prostate Cancer Treatment Response

Prostate cancer is one of the most common cancers in males and has one of the highest five-year survival rate when diagnosed in the localized stage. When diagnosed in the advanced stage or when a localized tumor relapses after the initial local treatment, the usual procedure is to fight it using male hormone (androgen) deprivation therapy. More...
27 Nov 2018
Image: The Leica TCS SP5 Confocal microscope fully covers a broad range of requirements in confocal and multiphoton imaging with excellent overall performance. The system provides the full range of scan speeds at the highest resolution (Photo courtesy of Leica Microsystems).

Recognized Cause of Pediatric Mitochondrial Disease Found

Leigh syndrome is a frequent, heterogeneous pediatric presentation of mitochondrial oxidative phosphorylation (OXPHOS) disease, manifesting with psychomotor retardation and necrotizing lesions in brain deep gray matter. More...
26 Nov 2018
Image: A micrograph of a mucinous ovarian carcinoma (Photo courtesy of Wikimedia Commons).

Ovarian Cancer Test Measures Biomarker Serum Levels

A new blood test for the diagnosis of ovarian cancer measures serum levels of the biomarker N-glycolylneuraminic acid (Neu5Gc). More...
26 Nov 2018
Image: A suggested workflow of genetic testing in a person with unexplained epilepsy. Genetic tests should be re-interpreted at least every two years for pediatric patients with epilepsy (Photo courtesy of International League Against Epilepsy).

Childhood Epilepsy Diagnoses Shift with Genomic Reinterpretation

Clinical genomic tests that examine the DNA sequence of large numbers of genes are commonly used in the diagnosis and management of epilepsy in pediatric patients. The permanence of genomic test result interpretations is not known. More...
22 Nov 2018
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Genetic Testing channel of LabMedica brings the latest in molecular genetics, cytogenetics, and epigenetics, and methods from PCR to FISH, and more.
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