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Molecular Diagnostics

Image: Histopathology of dissected appendiceal tissue showing moderately differentiated neoplastic glands lined by cells with nuclear pleomorphism and hyperchromasia (Photo courtesy of Pacific Northwest University of Health Sciences).

Distinct Mutation Patterns Identified in Appendiceal Cancer

The incidence of appendiceal cancer (AC) is rising, particularly among individuals younger than 50 years (early-onset AC), with unexplained etiologies. The unique spectrum of somatic cancer gene variations among patients with early-onset AC is largely undetermined. More...
24 Dec 2020
Image: Micrograph showing a prostate cancer (conventional adenocarcinoma) with perineural invasion (Photo courtesy of Wikimedia Commons)

Novel Classification System Identifies Prostate Cancer Patients Who May Benefit from Combined Immune and Radiation Therapies

A novel classification system is expected to aid in the subtyping of aggressive prostate cancers in patients who may benefit from combined immune and radiation therapies. More...
22 Dec 2020
Image: Tau proteins are a group of six highly soluble protein isoforms, which have help maintain the stability of microtubules in the axons and neurons of the central nervous system (Photo courtesy of NeuroscienceNews.com)

Plasma Levels of N-terminal Tau Fragments Predict Likelihood of Cognitive Decline in Elderly Individuals

A team of neurodegenerative disease researchers found that higher levels of N-terminal fragment of tau (NT1) in blood samples taken at the beginning of a survey of clinically normal elderly individuals were strongly associated with future risk of cognitive decline and progression to Alzheimer's disease. More...
21 Dec 2020
Image: nCounter NanoString: Gene expression profiling platform (Photo courtesy of Institute Pasteur).

Gene Expression Signature Traces Nonalcoholic Fatty Liver Disease Progression

Nonalcoholic fatty liver disease (NAFLD) is a common condition marked by the accumulation of triglycerides and other lipids in the liver and is associated with metabolic syndrome, type 2 diabetes, hypertension, and dyslipidemia. More...
16 Dec 2020
Image: The RNA of the coronavirus was extracted from the patient sample, which then underwent reverse transcription, gene amplification, and detection through nanoPCR to diagnose the COVID-19 infection. For rapid gene amplification and detection, magneto-plasmonic nanoparticles (MPNs) were used to facilitate the temperature change cycle of the existing RT-PCR at high speed. Finally, a magnetic field separated the MPN, and the fluorescent signal of the amplified DNA was detected (Photo courtesy of Institute for Basic Science, Korea)

Rapid Decentralized Testing for Diagnosis of COVID-19

A novel "nanoPCR" technique enables diagnosis of COVID-19 infections in less than 20 minutes with the accuracy of the current PCR method. More...
15 Dec 2020
Image: A `heat map` of the brain of a person with mild Alzheimer's dementia shows where tau protein has accumulated, with areas of higher density in red and orange, and lower density in green and blue (Photo courtesy of Tammie Benzinger/Knight ADRC)

Microtubule Binding Region of Tau Protein Is a Biomarker for Diagnosis of Alzheimer’s Disease

A recent paper highlighted the presence and potential utility of MTBR-tau species as biomarkers for diagnosis of Alzheimer’s disease. More...
14 Dec 2020
Image: An artist`s conception of nanodiamonds used for in vitro diagnostics (Photo courtesy of Ella Maru Studio, University College London)

Nanodiamonds Dramatically Boost Immunoassay Sensitivity

Incorporation of a specific class of nanodiamond into lateral flow immunoassays was shown to increase the sensitivity of this method by at least five orders of magnitude. More...
08 Dec 2020
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Genetic Testing channel of LabMedica brings the latest in molecular genetics, cytogenetics, and epigenetics, and methods from PCR to FISH, and more.
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