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Molecular Diagnostics

Image: Histological features of COVID-19 lungs (Photo courtesy of the University of Trieste).

COVID-19 Lung Damage Caused by Persistence of Abnormal Cells

Several uncertainties still relate to the involvement of other organs in COVID-19. Besides indirect multi-organ injury, a few reports have suggested the possibility of direct injury caused by viral replication in brain, heart and kidney. More...
19 Nov 2020

Levels of MicroRNAs in Saliva Are Diagnostic for Mild Traumatic Brain Injury

Measurement of levels of microRNAs in saliva was used to diagnose the presence of concussion (mild traumatic brain injury or mTBI) in a group of patients suffering from head trauma. More...
17 Nov 2020
Image: Schematic diagram of cell-free methylated DNA immunoprecipitation and high-throughput sequencing (cfMeDIP-seq) (Photo courtesy of Princess Margaret Cancer Centre).

Methylated DNA Profiling Explored for Prenatal Testing Applications

A method for analyzing cell-free methylated DNA being developed for use in cancer liquid biopsy testing can potentially also be used for prenatal testing applications. More...
17 Nov 2020
Image: Model of C-reactive protein (CRP) (Photo courtesy of Wikimedia Commons)

CRP Tracking Predicts Potential Outcome for Hospitalized COVID-19 Patients

By tracking the increase in circulating levels of the inflammatory biomarker C-reactive protein, doctors are able to predict whether newly hospitalized COVID-19 patients will suffer respiratory deterioration with the possible need for intubation. More...
16 Nov 2020
Image: Vacuolated erythroid precursors in the bone marrow are sometimes found in patients with severe adult-onset autoinflammatory disorder (Photo courtesy of Teresa S. Scordino, MD).

Blood Cell Mutations Underlie Severe Autoinflammatory Disease

Severe adult-onset autoinflammatory disorders often manifest with overlapping clinical features. Affected individuals may develop episodes of high, spiking fevers, a pink or salmon colored rash, joint pain, muscle pain, a sore throat and other symptoms associated with systemic inflammatory disease. More...
12 Nov 2020
Image: Structure of the neutrophil gelatinase-associated lipocalin (uNGAL) protein (Photo courtesy of Wikimedia Commons)

A New Approach for Rapid Detection of Acute Kidney Injury in Children

Measurement of a urinary protein combined with a calculated renal angina index was used to identify the early signs of acute kidney injury in children. More...
10 Nov 2020
Image: The Qiagen miRNeasy serum/plasma miRNA isolation kit (Photo courtesy of Qiagen).

Molecular Blood Test Kit Detects Gastric Cancer Early

Gastric cancer (GC) is the fifth most common cancer and the third-leading cause of cancer deaths worldwide. GC mortality is high due to late presentation. In most countries, mass screening is neither feasible nor cost-effective because such screening methods are costly and invasive, with poor compliance. More...
09 Nov 2020
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