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Molecular Diagnostics

Image: The Chromium Controller rapidly and efficiently combines large partition numbers with a massively diverse barcode library to generate >100,000 barcode-containing partitions in a matter of minutes. (Photo courtesy of 10x Genomics)

Endometrium Undergoes Gene Expression Shifts During Menstrual Cycle

In a human menstrual cycle the endometrium undergoes remodeling, shedding and regeneration, all of which are driven by substantial gene expression changes in the underlying cellular hierarchy. More...
29 Sep 2020
Image: A field-applicable, ultrasensitive diagnostic assay specifically detects DNA and RNA sequences from all Plasmodium species in symptomatic and asymptomatic malaria, and delivers its results fast in simple reporter devices (Photo courtesy of Peter Nguyen, Harvard University)

Rapid One-Step Assay for Field-Based Detection of Asymptomatic Malaria

A novel CRISPR-based ultrasensitive assay system was able to detect the four major types of malaria-causing parasites and has been streamlined for use in locations lacking the advanced laboratory equipment and highly trained technicians required for tests such as RT-qPCR, which is used extensively for monitoring the COVID-19 pandemic. More...
29 Sep 2020
Image: Scanning electron microscope (SEM) image showing SARS-CoV-2 (round gold objects) emerging from the surface of laboratory cultured cells (Photo courtesy of [U.S.] National Institute of Allergy and Infectious Diseases)

One-Step CRISPR-Based Assay Could Streamline COVID-19 Testing

An advanced CRISPR-based diagnostic test for COVID-19 produces results in 30 to 60 minutes, with accuracy similar to the standard CDC (Centers for Disease Control and Prevention) RT- qPCR test now in routine use. More...
28 Sep 2020
Image: Photomicrograph of histopathology of Barrett`s esophagus showing the characteristic goblet cells (Alcian blue stain) (Photo courtesy of Nephron).

Genomic Copy Number Predicts Esophageal Cancer Years Before Transformation

Barrett’s esophagus is a condition in which the lining of the esophagus changes, becoming more like the lining of the small intestine rather than the esophagus. This occurs in the area where the esophagus is joined to the stomach. More...
23 Sep 2020
Image: Illustration demonstrating painless and biodegradable microneedles on a paper patch (Photo courtesy of University of Tokyo)

Paper-Based Microneedle Skin Patch for Continuous Glucose Monitoring

A microneedle skin patch for the continuous monitoring of an individual’s glucose level was designed to be a painless and disposable screening and diagnostic test for diabetes patients, as well as those with pre-diabetes. More...
23 Sep 2020
Image: The Guardant360 tests 74 genes in a blood sample to identify the presence of spot tumor mutations, reordering, insertions and deletions (indels), as well as microsatellite instability (Photo courtesy of MygeneLab).

Circulating Tumor DNA Analysis Directs Therapy in Breast Cancer

Multiple tumor mutations are potentially targetable for advanced breast cancer treatment. Some of these mutations are common, such as activating PIK3CA mutations that are targetable with PI3K inhibitors. More...
22 Sep 2020
Image: The Aedes aegypti mosquito can spread various tropical diseases including dengue, zika, and chikungunya, which have similar symptoms (Photo courtesy of Gwangju Institute of Science and Technology)

A Paper-Based Nucleic Acid Testing Device for Rapid Diagnosis of Mosquito-Borne Viral Diseases

An all-in-one nucleic acid testing device loaded into a paper chip forms the basis for a simple, rapid diagnostic test for a range of mosquito-borne viral diseases. More...
22 Sep 2020
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Genetic Testing channel of LabMedica brings the latest in molecular genetics, cytogenetics, and epigenetics, and methods from PCR to FISH, and more.
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