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Molecular Diagnostics

Image: Comparison of brain tissue from a healthy individual and an Alzheimer\'s disease (AD) patient, demonstrating extent of neuronal death (Photo courtesy of [U.S.] National Institutes of Health via Wikimedia Commons)

Plasma Levels of Neurofilament Light Chain Protein Accurately Identify Neurodegenerative Disease Patients

A recent paper indicated that levels of neurofilament light chain (NfL) protein in the blood can be used to identify individuals who might have a neurodegenerative disease such as Alzheimer's disease (AD), Down's syndrome dementia, amyotrophic lateral sclerosis (ALS), atypical parkinsonian disorders, or frontotemporal dementia when clinical symptoms are not definitive. More...
16 Jun 2021
Image: Mucin proteins (green) in a sample of airway mucus (Photo courtesy of University of North Carolina)

A Mucin Protein Is a New Prognostic Biomarker for Chronic Obstructive Pulmonary Disease

The mucin protein MUC5AC has been shown to be a novel biomarker for chronic obstructive pulmonary disease (COPD) prognosis and for testing the efficacy of potential therapeutic agents. More...
15 Jun 2021
Image: An automated Leica BOND-III immunostainer (Photo courtesy of Leica Biosystems)

Low-Cost Transcriptional Diagnostic Accurately Categorizes Lymphomas

Lymphoma is a cancer of the lymphatic system, which is part of the body's germ-fighting network. The lymphatic system includes the lymph nodes (lymph glands), spleen, thymus gland and bone marrow. Lymphoma can affect all those areas as well as other organs throughout the body. More...
14 Jun 2021
Image: Crypts and buds in the small intestine and colon (Photo courtesy of Dr. Maree Faux, Walter and Eliza Hall Institute)

Circulating Tumor DNA Following Surgery Predicts Colorectal Cancer Recurrence

 According to a recent paper, levels of circulating tumor DNA (ctDNA) – which can be measured using noninvasive liquid biopsy – predict the likelihood of recurrence of colorectal cancer following surgery. More...
14 Jun 2021
Image: The NovaSeq 6000 performs whole-genome sequencing (Photo courtesy of Illumina)

Familial Hypercholesterolemia Tends to Slip Past Genetic Tests

Familial hypercholesterolemia is a genetic disorder characterized by high cholesterol levels, specifically very high levels of low-density lipoprotein (LDL), in the blood and early cardiovascular disease. The most common mutations diminish the number of functional LDL receptors in the liver. More...
10 Jun 2021
Image: Bone marrow aspirate showing mature plasma cells with eccentric nuclei and abundant basophilic cytoplasm indicative of multiple myeloma (Photo courtesy of Dr. David Israel Garrido, MD et.al.)

Personalized CtDNA Analysis Detects Minimal Residual Disease

Multiple myeloma (MM), is a type of bone marrow cancer. It is called multiple myeloma as the cancer often affects several areas of the body, such as the spine, skull, pelvis and ribs. Minimal residual disease (MRD) is the name given to small numbers of leukemic cells that remain in the person during treatment, or after treatment when the patient is in remission. More...
08 Jun 2021
Image: First biomarker in blood that distinguishes myocarditis from an acute myocardial infarction (Photo courtesy of Centro Nacional De Investigaciones Cardiovasculares)

Blood MicroRNA Biomarker Distinguishes Myocarditis from Myocardial Infarction

A novel microRNA has been found that can be used to distinguish patients with myocarditis from those with myocardial infarction. More...
08 Jun 2021
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Genetic Testing channel of LabMedica brings the latest in molecular genetics, cytogenetics, and epigenetics, and methods from PCR to FISH, and more.
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