Molecular Diagnostics

Liquid Biopsies Detect Pediatric Bone Tumors Based on Epigenetic Profiles
Sequencing of cell-free DNA (cfDNA) in the blood of cancer patients (liquid biopsy) provides attractive opportunities for early diagnosis, assessment of treatment response, and minimally invasive disease monitoring. As a consequence, cfDNA analysis holds great promise for precision oncology and personalized therapies, and is currently evaluated in a broad range of clinical studies. More...17 Jun 2021

Genomic Differences Cause Racial Disparities in Prostate Cancer
Prostate cancer is a disease defined by the abnormal growth of cells. These abnormal cells can proliferate in an uncontrolled way and, if left untreated, form tumors which may metastasize or spread to other parts of the body. Prostate cancer (PCa) is the most common solid organ malignancy in men, with 174,650 new diagnoses and 31,620 deaths expected in 2019 in the USA alone. More...17 Jun 2021
![Image: Comparison of brain tissue from a healthy individual and an Alzheimer\'s disease (AD) patient, demonstrating extent of neuronal death (Photo courtesy of [U.S.] National Institutes of Health via Wikimedia Commons) Image: Comparison of brain tissue from a healthy individual and an Alzheimer\'s disease (AD) patient, demonstrating extent of neuronal death (Photo courtesy of [U.S.] National Institutes of Health via Wikimedia Commons)](https://globetechcdn.com/mobile_labmedica/images/stories/articles/article_images/2021-06-16/GMS-047B.jpg)
Plasma Levels of Neurofilament Light Chain Protein Accurately Identify Neurodegenerative Disease Patients
A recent paper indicated that levels of neurofilament light chain (NfL) protein in the blood can be used to identify individuals who might have a neurodegenerative disease such as Alzheimer's disease (AD), Down's syndrome dementia, amyotrophic lateral sclerosis (ALS), atypical parkinsonian disorders, or frontotemporal dementia when clinical symptoms are not definitive. More...16 Jun 2021


Low-Cost Transcriptional Diagnostic Accurately Categorizes Lymphomas
Lymphoma is a cancer of the lymphatic system, which is part of the body's germ-fighting network. The lymphatic system includes the lymph nodes (lymph glands), spleen, thymus gland and bone marrow. Lymphoma can affect all those areas as well as other organs throughout the body. More...14 Jun 2021

Circulating Tumor DNA Following Surgery Predicts Colorectal Cancer Recurrence
According to a recent paper, levels of circulating tumor DNA (ctDNA) – which can be measured using noninvasive liquid biopsy – predict the likelihood of recurrence of colorectal cancer following surgery. More...14 Jun 2021

Familial Hypercholesterolemia Tends to Slip Past Genetic Tests
Familial hypercholesterolemia is a genetic disorder characterized by high cholesterol levels, specifically very high levels of low-density lipoprotein (LDL), in the blood and early cardiovascular disease. The most common mutations diminish the number of functional LDL receptors in the liver. More...10 Jun 2021
In Other News
Personalized CtDNA Analysis Detects Minimal Residual Disease
Blood MicroRNA Biomarker Distinguishes Myocarditis from Myocardial Infarction
A Novel Liquid Biopsy Technique for Diagnosis of Cancers in Children
Analytic Validation and Clinical Utilization of Comprehensive Genomic Profiling Test
Colorectal Cancer Relapse Predicted by ctDNA Clearance
Urinary Interleukin-8 May Be the Ultimate Bladder Cancer Biomarker
Plasma-Based Algorithm Accurately Predicts Likelihood of Developing Alzheimer’s Disease
Jagged Ends of Urinary Cell-Free DNA Assessed in Bladder Cancer Detection
Early Warning Biomarker Proteins Appear Years or Decades Before Alzheimer’s Disease Symptoms
Non‐Invasive Urine Markers Differentiate Renal Cancer from Oncocytoma
Measurement of Oxidized Serum Albumin for Diagnosis of Diabetic Kidney Disease
Jagged Ends of Urinary Cell-Free DNA Assessed in Bladder Cancer Detection
Rapid, Automated Test Detects Gonorrhea and Determines Antibiotic Susceptibility
Loss of Function Mutations in GEMIN5 Causes Neurodevelopmental Disorder
Elevated Cytokine Levels Linked to Future Development of Myocardial Infarction
New Blood Test Promises Biopsy-Free Colon Cancer Diagnosis
A Novel Capsule-Based Smell Test for Diagnosis of Neurological and Respiratory Diseases
Genetic Background and Clinicopathologic Features Established for Adult-Onset Nephronophthisis
LAMP Assay Developed to Diagnose High HBV DNA Levels
Protein Biomarker Increases Sensitivity of a Urine-based Prostate Cancer Test
Blood-based Liquid Biopsy Detects Lymph Node Metastasis in Colorectal Cancer Patients
GPS Assay Associated with Long-Term Prostate Cancer Outcomes
A Rapid Metabolomic Test for Early Diagnosis of Myocardial Infarction
Genetic Testing channel of LabMedica brings the latest in molecular genetics, cytogenetics, and epigenetics, and methods from PCR to FISH, and more.








