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Molecular Diagnostics

Image: The ID Core XT BLOODchip is a molecular-based assay used in blood transfusion medicine to help determine blood compatibility and could supplement the classical blood match methodology (Photo courtesy of Progenika Biopharma SA).

Next-Gen Sequencing Matches Blood Group Antigens for Transfusion

Transfusion is the procedure of introducing donor material with unknown blood cell antigens into the recipient’s circulatory system. The recipient’s immune system recognizes foreign antigens, produces specific antibodies and sensitization (alloimmunization) occurs. More...
26 Sep 2019
Image: Breath analysis of lung cancer patients with the eNose device could identify patients who would or would not respond to immunotherapeutic treatment with 85% accuracy (Photo courtesy of Amsterdam University Medical Centers).

Breath Analysis Identifies Cancer Patients Likely to Benefit from Immunotherapy

An “electronic nose” analytical device has been developed that can determine the likelihood of a cancer patient to respond successfully to immunotherapy. More...
22 Sep 2019
Image: A micrograph of the superficial cerebral cortex showing neuron loss and reactive astrocytes in a person who has had a stroke (Photo courtesy of Wikimedia Commons).

Distinctive mRNA Signatures May Prove Diagnostic for Cancer-Related AIS

A recently published paper described a distinctive molecular signature present in blood mRNA expression profiles of patients with cancer-related acute ischemic stroke (AIS) that could potentially lead to earlier diagnosis of cancer in these patients. More...
22 Sep 2019
Image: The MagPlex Multiplexing Microspheres (Photo courtesy of Luminex).

Multiplex Microsphere Immunoassay Identifies Three Flavivirus Infections

The explosive spread of Zika virus (ZIKV) and associated complications in flavivirus-endemic regions underscore the need for sensitive and specific serodiagnostic tests to distinguish ZIKV, dengue virus (DENV) and other flavivirus infections. More...
19 Sep 2019
Image: The multigene germline panel test prospectively searches for pathogenic or likely pathogenic variants in 30 genes (Photo courtesy of Color Genomics).

Pathogenic Germline Variants Found in Breast Cancer Patients

There is still considerable debate on the value of multigene panel testing for inherited cancer in patients with breast cancer, based on both the prevalence of pathogenic/likely pathogenic (P/LP) variants and any therapeutic implications from genetic test results. More...
18 Sep 2019
Image: Islet of Langerhans from the pancreas of a patient with chronic Type 1 diabetes of 19 years duration. A single lobe of the pancreas was found to contain islets rich in residual beta cells (alpha cells in red; beta cells in green) (Photo courtesy of Diapedia).

Biomarker Identified for Early Beta-Cell Death in Type 1 Diabetes

Beta cells in the pancreas produce insulin and their death is a key feature of Type 1 diabetes, and that loss starts long before diagnosis. However, there has been no straightforward way to measure that early loss. More...
18 Sep 2019
Image: The Parsortix system for collection of circulating tumor cells (Photo courtesy of ANGLE plc).

Automated Collection of CTCs Improves Prostate Cancer Diagnosis

A recent paper described the benefits of circulating tumor cell (CTC) analysis for improving the diagnosis of aggressive prostate cancer beyond currently used PSA (prostate specific antigen) measurement, biopsy and/or MRI imagery. More...
16 Sep 2019
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Genetic Testing channel of LabMedica brings the latest in molecular genetics, cytogenetics, and epigenetics, and methods from PCR to FISH, and more.
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