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Molecular Diagnostics

Image: High magnification micrograph of Castleman disease, hyaline vascular variant, also known as angiofollicular lymph node hyperplasia and giant lymph node hyperplasia (Photo courtesy of Wikimedia Commons)

Blood Biomarkers Predict Likelihood of Castleman Disease Treatment Response

Biomarkers have been found in the blood that can be used to predict which patients with idiopathic multicentric Castleman disease are more likely to respond to siltuximab, the only [U.S.] Food and Drug Administration (FDA) approved treatment for the disorder. More...
13 Sep 2021
Image: Schematic representation of cancer-related biomolecules such as cells, proteins, nucleic acids, miRNA and microvesicles circulating into the bloodstream, and collection of these biomarkers by liquid biopsy (Photo courtesy of University of Florence)

Liquid Biopsy Assay Evaluated for Early Detection of Gastric Cancer

Gastric cancer (GC) is the fourth most-commonly diagnosed cancer, and the third leading cause of cancer-associated mortality worldwide. Despite improvements in treatment modalities, the prognosis for advanced GC following curative resection remains poor. More...
08 Sep 2021
Image: Blood type is determined, in part, by the ABO blood group antigens present on red blood cells (erythrocytes) (Photo courtesy of Wikimedia Commons)

Genomics Approach Links ABO Blood Type to Inflammatory and Cardiovascular Diseases

A genomics approach that supplements classical blood typing procedures connects blood type phenotype to a large set of common inflammatory and cardiovascular diseases. More...
07 Sep 2021
Image: Scanning electron micrograph of a human T-cell from the immune system of a healthy donor (Photo courtesy [U.S.] National Institute of Allergy and Infectious Diseases)

Immune Cell Biomarker Predicts Response to Treatment with Checkpoint Inhibitor Drugs

A molecular signature based on an immune cell surface protein is a potential route toward determining a cancer patient’s response to treatment with checkpoint inhibitor drugs. More...
06 Sep 2021
Image: Novel PCR Test Could Quickly Distinguish Breast Cancer from Benign Tumors (Photo courtesy of Dr. Manman Shi)

Novel PCR Test Could Quickly Distinguish Breast Cancer from Benign Tumors

A novel laboratory test in development may be used to help quickly distinguish breast cancer from benign disease. More...
06 Sep 2021
Image: The MiSeq benchtop sequencer enables targeted and microbial genome applications, with high-quality sequencing, simple data analysis, and cloud storage (Photo courtesy of Illumina)

Molecular Characterization of Microbiota in Cerebrospinal Fluid Using WGA

Hydrocephalus is a common cause of neurological disability in children. Cerebrospinal fluid (CSF) shunt placement allows children with hydrocephalus to survive and avoid ongoing brain injury. More...
02 Sep 2021
Image: A healthy human liver. A biomarker linked to the organ donor predicts the likelihood that a transplanted liver will be accepted or rejected by the recipient of the organ (Photo courtesy of Wikimedia Commons)

Donor-Linked Biomarker Predicts Likelihood of Liver Transplant Success

A recent paper identified a biomarker linked to the organ donor that predicts the likelihood that a transplanted liver will be accepted or rejected by the recipient of the organ. More...
31 Aug 2021
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Genetic Testing channel of LabMedica brings the latest in molecular genetics, cytogenetics, and epigenetics, and methods from PCR to FISH, and more.
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