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Molecular Diagnostics

Image: Bone marrow of a pediatric patient with acute myeloid leukemia (Photo courtesy of St. Jude Children’s Research Hospital)

High-Risk Subtype of Relapsed Pediatric Acute Myeloid Leukemia Revealed

Scientists have found a previously overlooked mutation in a subtype of pediatric leukemia that has implications for identifying high-risk patients. More...
25 Feb 2022
Image: Representation of the structure of C-reactive protein (CRP) (Photo courtesy of Wikimedia Commons)

C-reactive Protein Level Can Replace Erythrocyte Sedimentation Rate for Defining the Severity of Ulcerative Colitis

A research team in Australia has determined that a blood level of C-reactive protein equal to or greater than 12 milligrams/liter is a practical alternative to measurement of ESR (Erythrocyte Sedimentation Rate) for defining the severity of ulcerative colitis. More...
24 Feb 2022
Image: Genome Sequencing Reveals Fetal Structural Anomalies (Photo courtesy of National Human Genome Research Institute)

Genome Sequencing Investigated for Prenatal Diagnosis of Fetal Structural Anomalies

Whole-genome sequencing is a promising alternative to currently used assays to diagnose fetal anomalies, a new analysis has found. More...
24 Feb 2022
Image: Photomicrograph of a poor to moderately differentiated adenocarcinoma of the stomach (Photo courtesy of Wikimedia Commons)

Genetic Signature Predicts Patients’ Response to Gastric Cancer Therapy

A 32-gene signature was developed and shown to be a promising prognostic and predictive biomarker to guide the clinical care of gastric cancer patients. More...
22 Feb 2022
Image: LumiraDx CRP Test (Photo courtesy of LumiraDx)

LumiraDx C-Reactive Protein (CRP) Test Achieves CE Marking

LumiraDx (London, UK) has achieved CE Marking for its C-reactive protein (CRP) Test, a small, portable, fully automated, microfluidic immunoassay test used for the quantitative determination of C-reactive protein with results within four minutes. More...
21 Feb 2022
Image: Schematic of the MOSAICA approach for labeling and analysis of spectral and time-resolved components (Photo courtesy of Nature Communications)

New Method for Three-Dimensional Analysis of Cancer Cells Shows Diagnostic Potential

A new biopsy method has been developed that can simultaneously profile multiple tumor microenvironment biomarkers and may potentially be used for cancer diagnosis and prognosis. More...
21 Feb 2022
Image: Histopathology of dilated cardiomyopathy of unknown etiology in a 58 year female. The histologic findings in dilated cardiomyopathy are usually nonspecific. The image shows myocyte hypertrophy with enlarged hyperchromatic nuclei, mixed with myocyte atrophy and stretching. In addition, there is focal interstitial fibrosis (Photo courtesy of Dr. Dharam Ramnani)

Titin-Truncating Variant Associated With Late-Onset Dilated Cardiomyopathy

Late-onset dilated cardiomyopathy might represent a distinct disease subtype marked by an increased burden of genetic variants, a new study has found. The findings further suggested that genetic testing may be beneficial for older dilated cardiomyopathy patients. More...
21 Feb 2022
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