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Molecular Diagnostics

Image: Extracting tumor epigenetics from blood (Photo courtesy of Tatjana Hirschmugl)

A Novel Liquid Biopsy Technique for Diagnosis of Cancers in Children

A novel liquid biopsy technique for cancer diagnosis in pediatric patients detects and quantifies epigenetic signatures based on cell-free DNA (cfDNA) fragmentation patterns. More...
07 Jun 2021
Image: Mutation profiles of clinically actionable genes in GEM ExTra. The twelve most reported genes and their mutation distribution across tumor types (Photo courtesy of Ashion Analytics)

Analytic Validation and Clinical Utilization of Comprehensive Genomic Profiling Test

Cancer has a high clinical burden and oncology therapies are expensive. It is estimated that 1,898,160 new cancer cases will be diagnosed and over 608,570 deaths are projected to occur in the USA in 2021. The prevalence of cancer is expected to rise over time, providing an expanding unmet need for genomic tests to help physicians treat patients in a more precise manner. More...
02 Jun 2021
Image: Schematics of the workflow for the Geneseeq Prime 425-gene panel (Photo courtesy of Geneseeq Technology)

Colorectal Cancer Relapse Predicted by ctDNA Clearance

Colorectal cancer (CRC) is the third most common cancer around the world with more than 1.9 million new cases diagnosed annually. CRC is also the second leading cause of cancer-related deaths with a 5-year mortality rate of about 40%. More...
01 Jun 2021
Image: A platform for multiplexing up to 100 analytes such as proteins in a single well of a microtiter plate (Photo courtesy of Luminex Corporation)

Urinary Interleukin-8 May Be the Ultimate Bladder Cancer Biomarker

A recently published study established that the urinary protein interleukin-8 (IL-8) not only distinguished bladder cancer from controls, it also discriminated high grade from low grade disease, and the successive clinical stages of bladder cancer. More...
01 Jun 2021
Image: Neurons were grown in tissue culture and stained with antibody to microtubule associated protein 2 (MAP2) protein in green and MAP tau in red. MAP2 is found only in dendrites and perikarya, while tau is found in these sites and in axons as well. DNA is shown in blue (Photo courtesy of EnCor Biotechnology Inc. via Wikimedia Commons)

Plasma-Based Algorithm Accurately Predicts Likelihood of Developing Alzheimer’s Disease

A team of Swedish researchers has created an algorithm for use by physicians lacking access to advanced diagnostic instruments, which accurately predicts future risk of developing Alzheimer’s disease (AD). More...
31 May 2021
Image: Schematic of workflow for urinary DNA jagged end analysis. Urinary DNA was subjected to an end-repair process; JI-U = jagged index–unmethylated (Photo courtesy of The Chinese University of Hong Kong)

Jagged Ends of Urinary Cell-Free DNA Assessed in Bladder Cancer Detection

Bladder cancer is where a growth of abnormal tissue, known as a tumor, develops in the bladder lining. In some cases, the tumor spreads into the bladder muscle. The most common symptom of bladder cancer is blood in the urine, which is usually painless. More...
27 May 2021
Image: Histopathology of Alzheimer\'s disease in the CA3 area of the hippocampus: Amyloid plaque (top right), neurofibrillary tangles (bottom left) and granulovacuolar degeneration (bottom center). All three images were taken at the same high magnification (Photo courtesy of Wikimedia Commons)

Early Warning Biomarker Proteins Appear Years or Decades Before Alzheimer’s Disease Symptoms

A large proteomic study linked abnormal blood levels of 38 proteins to higher risks of developing Alzheimer's disease within five years and showed that levels of 16 of these proteins could predict Alzheimer's disease risk two decades in advance. More...
26 May 2021
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Genetic Testing channel of LabMedica brings the latest in molecular genetics, cytogenetics, and epigenetics, and methods from PCR to FISH, and more.
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