Molecular Diagnostics
Testing for Protein in Blood Receives More Support as Biomarker for Brain Disorders
Frontotemporal dementia (FTD) is a group of brain disorders characterized by changes in behavior, cognition, language or movement that has few treatment options. These disorders involve degeneration and shrinkage of the frontal and temporal lobes of the brain. Now, a test of protein in the blood has received further support as a biomarker for patients diagnosed with FTD. More...21 Apr 2022
Blood Test to Diagnose Skin Cancer May Help Avoid Invasive Skin Biopsies
Recent advances in liquid biopsy have proposed less-invasive alternatives for cancer diagnosis and monitoring using minimal invasion at sample collection, and circulating tumor cells (CTCs) have been considered a promising blood-based surrogate marker of primary tumors. Now, new research indicates that testing an individual’s blood can reveal the presence of CTCs. Such tests may allow patients to forego invasive skin biopsies to determine whether they have skin cancer. More...21 Apr 2022
Tumor Suppressor Adenomatous Polyposis Coli Regulates T Lymphocyte Migration
Familial adenomatous polyposis (FAP) is an autosomal dominant inherited disease that often results from germline mutations in the adenomatous polyposis coli (APC) gene, a tumor suppressor and polarity regulator. APC protein regulates the Wnt/β-catenin signaling pathway as a component of the β-catenin destruction complex. More...20 Apr 2022
NGS Technology-Based Assay Detects Minimal Residual Disease in Patients with Lymphatic Hematological Tumors
A new assay based on high-throughput next generation sequencing (NGS) technology can test the CDR3 regional sequence of the IgH/K/L gene of the B cell receptor (BCR) in bone marrow samples collected from patients with B lymphpocytic leukemia (B-ALL/CLL) and multiple myeloma (MM) before and after the treatment. More...20 Apr 2022
World’s First Rapid Oral Cancer Test to Revolutionize Diagnosis and Treatment
Researchers at Queen Mary University of London (London, UK) have developed the world’s first PCR test for mouth cancer that may improve the early detection of oral cancer. The test is quick and easy. It only needs the PCR machine used in COVID testing and a technician to operate it. It could be rapidly rolled out around the world at very little extra cost. More...14 Apr 2022
Broad Gene Panel Diagnoses Patients With Kidney Disease
Chronic kidney disease (CKD) is a major public health issue in the USA. Identification of monogenic causes of CKD, which are present in ∼10% of adult cases, can impact prognosis and patient management. For the ∼800,000 individuals in the USA with end-stage kidney disease (ESKD), genetic diagnosis may inform the selection of potential-related kidney donors, assess the risk of disease recurrence, and guide clinical management following transplant. More...13 Apr 2022
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Genetic Testing channel of LabMedica brings the latest in molecular genetics, cytogenetics, and epigenetics, and methods from PCR to FISH, and more.