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Molecular Diagnostics

Image: A new liquid-based personalized cancer monitoring platform can help detect disease earlier (Photo courtesy of Invitae Corporation)

Personalized Tumor-Informed Assay Helps Patients Get Ahead of Cancer

Over the past several years, research has shown that minimal or molecular residual disease (MRD) monitoring can reliably identify lung cancer patients at high risk of relapse, detect post-surgical recurrence often earlier than standard imaging, assess therapy response, and potentially act as a surrogate for clinical trial endpoints. Now, a newly-available platform can help detect MRD in patients with solid tumors. More...
22 Mar 2022
Image: ‘Worm-on-a-chip’ device could someday help diagnose lung cancer (Photo courtesy of Myongji University)

Worm-on-a-Chip Device Could Noninvasively Diagnose Early-Stage Cancer

Dogs can use their incredible sense of smell to sniff out various forms of cancer in human breath, blood and urine samples. Similarly, in the lab a much simpler organism, the roundworm C. elegans, wriggles its way toward cancer cells by following an odor trail. Scientists have now reported a device that uses the tiny worms to detect lung cancer cells. More...
22 Mar 2022
Image: The Illumina Next-Seq 500 sequencer (Photo courtesy of Adam Armstead)

Pediatric Cancer Sequencing Expands Relapse Treatment Options

New data has demonstrated that sequencing the tumors of relapsing pediatric cancer patients can uncover alterations linked to existing and emerging targeted therapies, potentially offering improved outcomes over standard chemotherapy. More...
21 Mar 2022
Image: Confocal microscope study of p-syn deposits in a dermal arteriole of a patient with PD (Photo courtesy of Dr. Alex Incensi)

Alpha-Synuclein Skin Deposits Characterize Parkinson’s Disease Patients

The detection of skin deposits of the neurodegenerative disease biomarker protein alpha-synuclein (p-syn) may be useful for the differential diagnosis of parkinsonism. More...
18 Mar 2022
Image: Plasma biomarker screening could improve accuracy of Alzheimer’s disease diagnosis (Photo courtesy of Pexels)

Blood Plasma Biomarkers Could Improve Diagnostic Tests for Alzheimer's Disease

Alzheimer's disease is the most common form of dementia, with the African American population at the greatest risk for developing the disease. The findings of the first study to focus on RNA molecules in plasma as biomarkers for Alzheimer's disease in African Americans could lead to the development of improved diagnostic tests for the disease. More...
18 Mar 2022
Image: Illumina has launched a groundbreaking comprehensive genomic profiling test for cancer in Europe (Photo courtesy of Illumina Inc.)

Groundbreaking DNA Test Evaluates Biomarkers in 517 Cancer-Relevant Genes across 30 Types of Solid Tumors

Illumina Inc. (San Diego, CA, USA) has launched TruSight Oncology (TSO) Comprehensive (EU), a single test that assesses multiple tumor genes and biomarkers to reveal the specific molecular profile of a patient's cancer. More...
17 Mar 2022
Image: The Cellometer K2 utilizes brightfield imaging and dual-fluorescence imaging to quickly and accurately identify and count individual cells. Cell count, concentration, diameter, and % viability are automatically calculated and reported (Photo courtesy of Nexcelom Bioscience)

Single Cell Characterization Acral Melanoma Identifies Novel Targets for Immunotherapy

Acral melanoma is a rare subtype that represents roughly 3% of all melanoma cases. Unlike typical melanoma that occurs on sun-exposed skin, acral melanoma develops on the nonhair bearing skin of the soles, palm and nail beds. There is very little information known about the development of acral melanoma. More...
16 Mar 2022
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