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Molecular Diagnostics

Image: Schematic structure of the thrombomodulin protein (Photo courtesy of Wikimedia Commons)

Thombomodulin Identified as Unique Biomarker for Diagnosing Necrotizing Soft-Tissue Infections

Thrombomodulin, a protein present in blood plasma, is a biomarker that may be useful for diagnosing necrotizing soft-tissue infections. More...
26 Jul 2021
Image: The Lumipulse G β-amyloid 1-40 assay kit (Photo courtesy Fujirebio)

APOE Gene Influences Alzheimer's Symptoms, Biomarkers in Down Syndrome

Individuals with Down syndrome (DS) constitute a population at ultrahigh risk of developing Alzheimer disease (AD) because of trisomy of chromosome 21, which harbors the amyloid precursor protein (APP) gene. More...
22 Jul 2021
Image: Axiom Genome-Wide Population-Optimized Human Arrays are genotyping panels that offer the best genetic coverage of rare and common variants for genome-wide disease association studies (Photo courtesy of Thermo Fisher Scientific)

Preemies' Blood Type Tied to Risk for Necrotizing Enterocolitis

Necrotizing enterocolitis (NEC) and focal intestinal perforation (FIP) are two of the most common emergencies of the gastrointestinal tract in preterm infants with very low birth weight (VLBW). The etiology and pathogenesis of NEC and FIP remain poorly understood. More...
21 Jul 2021
Image: The Bionano Genomics Saphyr instrument used for Optical Genome Mapping (Photo courtesy of Bionano Genomics)

Optical Genome Mapping Enables Constitutional Chromosomal Aberration Detection

Optical genome mapping (OGM) is a novel method that fills this void by being able to detect all classes of structural variations (SVs), including copy number variations (CNVs). OGM is being adopted by laboratories as a tool for both postnatal constitutional genetic disorders and hematological malignancies. More...
20 Jul 2021
Image: Artist’s rendition of the SARS-CoV-2 virus, which causes COVID-19 (Photo courtesy of Pixabay)

Serum Biomarkers Enable Tracing the Progress of COVID-19 Infections

A team of Spanish investigators has shown that levels of angiotensin-converting enzyme 2 and various truncated versions of this protein in the blood could be used as biomarkers for following the progress of COVID-19 infection in hospitalized patients. More...
20 Jul 2021
Image: GeneXpert System Xpert-CARBA test for the detection and differentiation of KPC, NDM, VIM, IMP-1, and OXA-48 in 48 minutes (Photo courtesy of Cepheid)

Rectal Colonization by Klebsiella Leads to Different Risks for Bacteremia

Carbapenem-resistant Enterobacterales (CRE) represent a threat for public health, being among the top multidrug-resistant pathogens. Intestinal colonization by CRE is a risk factor for developing subsequent infection. More...
20 Jul 2021
Image: Telomerase reverse transcriptase (TERT) expression in non-lentiginous acral melanoma (NLAM) and non-acral cutaneous melanoma (NACM): (A) exhibiting 1+ TERT staining intensity and (B) The intensity of TERT expression and proportion of TERT-positive cells could also vary in cutaneous melanomas (Photo courtesy of MD Anderson Cancer Center)

Telomerase Reverse Transcriptase Protein Expression Evaluated for Melanomas

Telomeres are regions of repetitive nucleotide sequences located at the ends of chromosomes that play a key role in the maintenance of genomic integrity and stability in cells. In normal nonneoplastic somatic cells, telomeres progressively shorten with successive cell divisions. More...
19 Jul 2021
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Genetic Testing channel of LabMedica brings the latest in molecular genetics, cytogenetics, and epigenetics, and methods from PCR to FISH, and more.