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Molecular Diagnostics

Image: The QuikRead go iFOBT is an immunochemical fecal immunochemical test for detection and quantification of human hemoglobin in feces in case of suspected bleeding from the lower gastrointestinal tract (Photo courtesy of Aidian)

Fecal Immunochemical Tubes Sourced to Analyze Gut Microbiome for CRC

Colorectal cancer (CRC) is a challenging public health problem which successful treatment depends on the stage at diagnosis. Recently, CRC-specific microbiome signatures have been proposed as a marker for CRC detection. More...
14 Oct 2021
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First-of-Its-Kind Testing Device Allows For Rapid Detection of Bacteria That Identify Risk for Preterm Birth

A newly-developed cost-effective device can rapidly and accurately detect changes in vaginal bacteria and corresponding immune responses in pregnant women, which are associated with increased risk of preterm birth. More...
14 Oct 2021
Image: Bone marrow aspirate from a patient with peripheral T-cell lymphoma (Photo courtesy of Peter Maslak, MD)

Mutation Analysis Links Angioimmunoblastic T-Cell Lymphoma to Clonal Hematopoiesis

Peripheral T-cell lymphoma (PTCL) is a heterogeneous group of lymphoid tumors and encompass peripheral T-cell lymphoma, not otherwise specified (PTCL-NOS), angioimmunoblastic T-cell lymphoma (AITL), and several other entities of T-cell lymphoma. More...
13 Oct 2021
Image: The GeneXpert MTB/RIF assay for tuberculosis and rifampicin resistance was compared with unique gene to detect Mycobacterium tuberculosis (Photo courtesy of Cepheid)

Unique Gene Detects Mycobacterium Tuberculosis in Clinical Sputum

Tuberculosis (TB) is a common infectious disease caused by Mycobacterium tuberculosis (MTB). The main organ infected by MTB is the lung, but many other tissues or organs can be affected, such as the bone and pleura. Two million people die of MTB infection each year due to poor quality of life and lack of awareness. More...
13 Oct 2021
Image: Effect of whole-genome sequencing on the clinical management of acutely ill infants with suspected genetic disease investigated (Photo courtesy of Illumina)

Whole-Genome Sequencing Applied to Acutely Ill Infants

Critically ill infants admitted to an intensive care unit are at risk for high levels of morbidity and mortality. In the USA, approximately 400,000 newborns are admitted to a neonatal ICU annually, costing at least USD 26 billion and accounting for up to 50% of the total national pediatric health care expenditure. More...
12 Oct 2021
Image: Micrograph showing a lymph node invaded by ductal breast carcinoma, with an extension of the tumor beyond the lymph node (Photo courtesy of Wikimedia Commons)

High Cell-Free DNA Integrity Is a Biomarker for Poor Breast Cancer Survival

A team of Finnish researchers has refined a liquid biopsy analysis technique to act as a more specific biomarker in order to more accurately predict poor prognosis for patients with aggressive breast cancer. More...
12 Oct 2021
Image: Pictured is a cross section of a peripheral artery from the leg of a patient with chronic limb-threatening ischemia (CLTI), a condition in which heavy plaque formation causes a severe narrowing of the arteries (Photo courtesy of Zayed Research Laboratory, Washington University School of Medicine)

Elevated Circulating Fatty Acid Synthase Is a Diagnostic Biomarker for Peripheral Artery Disease

Elevated levels of a soluble form of the enzyme fatty acid synthase (sFSA) in the blood have been linked to development of the severe vascular disorder peripheral artery disease (PAD). More...
11 Oct 2021
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