Molecular Diagnostics
Chitotriosidase Expression in Sarcoidosis Limited by Gene Expression
Sarcoidosis is a multisystem granulomatous disease which affects individuals worldwide of all ages irrespective of ethnicity or race. It is often recognized accidentally when a routine chest radiographic picture shows bilateral hilar lymphadenopathy. More...06 Jan 2021
Plasma Serglycin Levels Evaluated for Diabetic Retinopathy Diagnosis
Diabetic retinopathy (DR), a microvascular complication caused by chronic diabetes mellitus (DM), is a significant threat to vision in adults, which may even lead to blindness and retinal detachment. The clinical symptoms of DR include fibrosis, capillary obstruction, neovascularization, and increased vascular permeability. More...04 Jan 2021
Single-Cell Transcriptome Links Gut Development, Pediatric Crohn's Disease
Development of the human intestine is a highly complex process that requires synergy between a wide range of cell types. Importantly, environmentally triggered alterations in early development have been implicated in a range of immune-mediated pathologies, including inflammatory bowel diseases (IBD). More...29 Dec 2020
Rare Genetic Variants Can Contribute to Ischemic Heart Failure
Heart failure affects about 40 million people globally, and most cases are due to ischemic heart disease, hypertension, or cardiomyopathies. Cardiomyopathies have been traced to rare variants in genes that encode sarcomere or cytoskeletal proteins, channels, or desmosomes, while genome-wide association studies have underscored common variants linked to heart failure. More...29 Dec 2020
Osteopontin Linked to Progressive Lung Scarring in Scleroderma Patients
Systemic sclerosis (SSc) is an autoimmune disease characterized by a distinct pathogenic triad of microvascular damage, dysregulation of innate and adaptive immunity, and fibrosis involving skin and many internal organs, such as the heart, kidney, and lungs. More...28 Dec 2020
Next-Generation Sequencing Detects Residual Disease in Acute Lymphoblastic Leukemia
The use of next-generation sequencing (NGS) to detect residual disease in acute lymphoblastic leukemia (ALL) patients after treatment can better gauge their risk of relapse and overall survival than multiparameter flow cytometry. More...24 Dec 2020
Distinct Mutation Patterns Identified in Appendiceal Cancer
The incidence of appendiceal cancer (AC) is rising, particularly among individuals younger than 50 years (early-onset AC), with unexplained etiologies. The unique spectrum of somatic cancer gene variations among patients with early-onset AC is largely undetermined. More...24 Dec 2020
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Blood Biomarker Protein Correlates with Severity of Brain Damage in Stroke Patients
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Levels of MicroRNAs in Saliva Are Diagnostic for Mild Traumatic Brain Injury
Methylated DNA Profiling Explored for Prenatal Testing Applications
CRP Tracking Predicts Potential Outcome for Hospitalized COVID-19 Patients
Blood Cell Mutations Underlie Severe Autoinflammatory Disease
A New Approach for Rapid Detection of Acute Kidney Injury in Children
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Genetic Testing channel of LabMedica brings the latest in molecular genetics, cytogenetics, and epigenetics, and methods from PCR to FISH, and more.
