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Molecular Diagnostics

Image: A normal bone marrow biopsy: Note the presence of an eosinophilic myelocyte, a basophilic myelocyte, and a plasma cell. There is an association between a common, benign genotype and unnecessary bone marrow biopsies among African-American patients (Photo courtesy of University of Utah School of Medicine)

Genotyping Helps Avoid Needless Bone Marrow Biopsies in African-Americans

Bone marrow biopsies may be used unnecessarily in some African American individuals who are genetically predisposed to having relatively low white blood cell counts. More...
13 Jul 2021
Image: Artist’s depiction of stress molecules in blood being detected electronically inside nanowells (Photo courtesy of Ella Marushchenko)

A Novel Nanowell Array Sensor for POC Measurement of Stress Hormones

Researchers have constructed a microchip "nanosensor" to measure stress hormones such as cortisol in a dedicated nanowell array, which does not require molecular labels or washing steps. More...
13 Jul 2021
Image: Micrograph showing inflammation of the large bowel in a case of inflammatory bowel disease (Photo courtesy of Wikimedia Commons)

Novel Stool Biomarker Screening Tests Detect Colorectal Cancer and Inflammatory Bowel Disease

Two recent papers described the use of novel stool protein biomarkers in screening tests to diagnose colorectal cancer (CRC) and inflammatory bowel disease (IBD). More...
12 Jul 2021
Image: The proximity extension assay identified 19 plasma hub proteins (indicated as yellow dots in the figure) in AD patients, which were irregular compared to healthy people (Photo courtesy of Hong Kong University of Science and Technology)

Protein Biomarker Blood Test Accurately Detects Alzheimer’s Disease

A 19-protein biomarker panel distinguished Alzheimer’s disease (AD) patients from healthy individuals with greater than 96% accuracy and differentiated among the early, intermediate, and late stages of AD while monitoring the progression of the disease. More...
07 Jul 2021
Image: Micrograph image of human papilloma virus associated oropharyngeal cancer (HPV+ OPSCC). The tissue was stained to show the presence of the virus by in situ hybridization (Photo courtesy of Wikimedia Commons)

Sensitive PCR Test Predicts Treatment Response in Metastatic Head and Neck Cancers

A recently developed droplet digital PCR (ddPCR)-based assay for circulating tumor DNA (ctDNA) from human papillomavirus HPV16 (which is responsible for almost 90% of HPV-positive oropharyngeal cancers) predicts treatment response in metastatic human papillomavirus related (HPV+) oropharyngeal squamous cell carcinoma (OPSCC). More...
06 Jul 2021
Image:  The Galleri test is able to detect multiple types of cancers through a single blood draw (Photo courtesy of GRAIL, Inc.)

Blood-based Liquid Biopsy Test Accurately Detects More Than Fifty Types of Cancer

Results from a clinical study confirmed that a noninvasive liquid biopsy-based blood test could accurately detect more than 50 types of cancer and could be used as a multi-cancer screening test among individuals at higher risk of the disease, including asymptomatic individuals aged 50 years or older. More...
05 Jul 2021
Image: Space-filling model of the antigen-binding fragment of atezolizumab (pale blue) in complex with PD-L1 (pink) (Photo courtesy of Wikimedia Commons)

Circulating Tumor DNA Following Surgery Predicts Bladder Cancer Recurrence

A blood test that detects circulating tumor DNA (ctDNA) predicts risk of bladder cancer recurrence following surgery and can be used to guide precision treatment of the disease. More...
01 Jul 2021
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Genetic Testing channel of LabMedica brings the latest in molecular genetics, cytogenetics, and epigenetics, and methods from PCR to FISH, and more.