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Molecular Diagnostics

Image: Proposed mechanism of genetic material from tumor entering into circulation (Photo courtesy of University of Utah).

Tumor Markers in Blood Underpins Future Bowel Cancer Screening

The positivity from a two-gene DNA blood test increases with the depth of cancer invasion, tumor size, stage and presence of metastases in bowel cancer patients.   More...
09 Dec 2014
Image: Photomicrograph of endometriosis of the ovary (Photo courtesy of Nephron).

Noninvasive Test for Endometriosis Developed

Endometriosis is diagnosed and staged at surgery, resulting in an 11-year latency from symptom onset to diagnosis, underscoring the need for less invasive, less expensive approaches.   More...
07 Dec 2014
Image: NanoFlares-specially designed stem cells that have been developed to detect blood-borne cancers. When the cells come in contact with cancerous cells, they emit light (Photo courtesy of the International Institute for Nanotechnology at Northwestern University).

Nanoflares Detect Live Tumor Cells in Human Blood

Metastasis portends a poor prognosis for cancer patients and primary tumor cells disseminate through the bloodstream before the appearance of detectable metastatic lesions.  More...
07 Dec 2014
Image: The Genome Sequencer 454FLX system (Photo courtesy of Roche).

Real-Time Genome Sequencing Helps Control Hospital Outbreak

Whole-genome sequencing (WGS) of bacterial isolates provides a promising contemporary method for investigating the epidemiology of outbreaks, particularly when coupled to clinical locational and temporal data.   More...
01 Dec 2014
Image: The BN II protein analyzer system (Photo courtesy of Siemens).

Sickle Cell Trait Linked to Chronic Kidney Disease Risk

Sickle cell trait is defined as inheritance of a single copy of the sickle mutation that results from a single base pair substitution in the gene encoding the β-globin chain of hemoglobin.   More...
30 Nov 2014

Next-Generation Sequencing of Targeted Capture Genes a Sensitive Method for Diagnosis of Inherited Eye Disorders

A recent study showed that a targeted enrichment and next-generation sequencing method for genetic diagnostic testing of patients with inherited eye disorders was more accurate and sensitive than an approach based on exome sequencing, which focuses on the DNA in the 1% of the human genome that code for proteins.  More...
30 Nov 2014
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DNA Sequencing Identifies Mitochondrial Mutations in Glaucoma Patients

Diagnosis of glaucoma may be simplified by the development of a gene sequencing technique that detects mutations in the mitochondrial DNA of glaucoma patients.   More...
26 Nov 2014
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Genetic Testing channel of LabMedica brings the latest in molecular genetics, cytogenetics, and epigenetics, and methods from PCR to FISH, and more.
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