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Molecular Diagnostics

Image: The Myriad myPath Melanoma test differentiates malignant melanoma from benign skin lesions with a high level of accuracy (Photo courtesy of Myriad Genetics).

New Test Improves Reliability of Melanoma Diagnosis

New results support the use of a novel multigene test as an important adjunct to standard pathology techniques in the evaluation of potentially malignant pigmented skin lesions.  More...
12 Jun 2014
Image: Histopathology of a colon with adenocarcinoma showing chaotic appearance of glandular pattern (Photo courtesy of Johns Hopkins University).

DNA Blood Test Evaluated for Colorectal Cancer Detection

Tumor-derived aberrant DNA can be detectable in blood and blood tests have the potential to improve screening for colorectal cancer.  More...
11 Jun 2014
Image: Karyotype of Trisomy 22 showing three copies of chromosome 22 (Photo courtesy of Ewha Womans University School of Medicine).

New Genetic Sequencing Methods Means Accurate Embryo Screening

The clinical application of next generation DNA sequencing, a high throughput sequencing method, has the potential to revolutionize pre-implantation genetic screening.  More...
10 Jun 2014

New Software Tool Rapidly Finds Links Between Mutations and Disease in Families

A recent paper described a new software tool that allows the rapid sequencing of genes shared by families, which gives a more accurate picture of the linkage between mutations and disease.  More...
10 Jun 2014
Image: Exome sequencing workflow: Double-stranded genomic DNA is fragmented by sonication. Linkers are then attached to the DNA fragments, which are then hybridized to a capture microarray designed to target only the exons (Photo courtesy of Sarah Kusala).

Exome Sequencing Covers Specific Gene Sets Ineffectually

Clinical diagnosis can be made using exome sequencing, but may be regularly missed as there appears to be a high false-negative rate using existing sequencing kits.   More...
09 Jun 2014
Image: The HumanHT-12 v4 BeadChip Kit uses the DirectHyb Assay and is compatible with the iScan, HiScan, and Bead Array Reader systems (Photo courtesy of Illumina).

Microarray Analysis of Gene Expression Signatures in Blood Samples Provides Biomarker for Higher Cardiovascular Death Risk

Differences in gene expression have been found among a population of coronary artery disease patients that seemed to indicate which of them were at higher risk of dying from the illness.  More...
09 Jun 2014
Image: The Myriad myRisk Hereditary Cancer test uses next-generation sequencing to evaluate multiple clinically significant hereditary cancer genes associated with eight major hereditary cancers (Photo courtesy of Myriad Genetics).

New Multigene Test Improves Assessment of Hereditary Cancers

New clinical data shows that a test covering multiple relevant genes not only detects more deleterious mutations than single cancer tests, but also helps solve the overlap-dilemma that exists among hereditary cancer syndromes.  More...
09 Jun 2014
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Genetic Testing channel of LabMedica brings the latest in molecular genetics, cytogenetics, and epigenetics, and methods from PCR to FISH, and more.
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