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Molecular Diagnostics

Image: Schematic diagram of the ultrasensitive solution-phase method for detecting antibodies, by agglutination-polymerase chain reaction (ADAP) (Photo courtesy of the University of California, Berkeley).

Ultrasensitive Antibody Detection Enabled by Agglutination-PCR

Antibodies are widely used biomarkers for the diagnosis of many diseases and assays based on solid-phase immobilization of antigens comprise the majority of clinical platforms for antibody detection, but can be undermined by antigen denaturation and epitope masking.   More...
14 Mar 2016
Image: Schematics of workflow for whole-exome sequencing (Photo courtesy of Quest Diagnostics).

Whole-Exome Sequencing Identifies Rare Inherited Diseases

Whole-exome sequencing could serve as a viable diagnostic approach for identifying rare inherited diseases and providing a resolution for patients on a diagnostic odyssey, which are patients with a suspected genetic condition for whom previous standard genetic testing did not reveal a cause.  More...
14 Mar 2016
Image: Histopathological findings in laryngeal squamous cell carcinoma (Photo courtesy of Nikon Microscopy).

Gene Predicts Outcomes for Head and Neck Patients

A human cancer-causing gene, called the DEK oncogene, can be detected in the plasma of head and neck cancer patients and this may help doctors understand how a person's immune system could be used to treat cancer or predict outcomes for patients.   More...
08 Mar 2016
Image: Histopathology of two clusters of precancerous cells (lower half of image), which arose in pancreatic cells expressing the pancreas/duodenum homeobox protein 1 and the cancer gene KRAS (Photo courtesy of Sharon Friedlander).

Genomic Analyses Identifies Molecular Subtypes of Pancreatic Cancer

Most patients with pancreatic cancer only live a few months after diagnosis and the disease is set to become the second most common cancer in westernized countries in the next 10 years.  More...
07 Mar 2016
Image: Dot blots showing the expressions of total glycogen synthase kinase-3β (tGSK-3β) and p-GSK-3β (ser9) in the platelets; the differences of platelet GSK-3β activity between T2DM-nMCI group and T2DM-MCI group (Photo courtesy of Tongji Medical College).

Biomarkers Help Diagnose Mild Cognitive Impairment in Diabetics

Alzheimer's disease is the most common cause of senile dementia, and the prevalence is increasing with population aging and even when the clinical diagnosis of Alzheimer's disease is made, it is generally too late to be curable.  More...
02 Mar 2016
Image: Legionella sp. colonies growing on an agar plate and illuminated using ultraviolet light to increase contrast (Photo courtesy of CDC/James Gathany).

New Protocol Rapidly Detects Three Legionella Species

An innovative protocol has been developed for the detection of the three most prevalent Legionella species, enabling the source of the infection to be located in just eight hours.  More...
01 Mar 2016
Image: A blood test for DNA methylation levels of the gene encoding zinc finger protein 154 (ZNF154) can diagnose common cancers (Photo courtesy of US National Institutes of Health).

Blood Test Developed to Detect Five Early-Stage Cancers

A blood test to diagnose common types of cancer is in development after it was found that five forms of the disease share a telltale chemical signature.  More...
28 Feb 2016
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Genetic Testing channel of LabMedica brings the latest in molecular genetics, cytogenetics, and epigenetics, and methods from PCR to FISH, and more.