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Molecular Diagnostics

Image: Droplet digital polymerase chain reaction system (Photo courtesy of Bio-Rad).

Blood Samples Analysis Monitors Colorectal Cancer Chemotherapy Response

Circulating cell-free DNA may be collected from plasma of colorectal cancer patients and represents a less invasive, less costly approach to tracking biomarkers of interest longitudinally and at progression.  More...
18 Nov 2015
Image: The Diagnostics-in-a-Suitcase used to screen for Ebolavirus disease (Photo courtesy of Institut Pasteur, Dakar).

Rapid Ebola Virus Detection Assay Evaluated

Ebolavirus infection is mainly diagnosed by various in-house and commercial real-time reverse transcriptase polymerase chain reaction assays used in up to 38 laboratories implemented at or close to Ebola treatment centers in West Africa.  More...
17 Nov 2015
Image: Schematic diagram of circulating tumor DNA (ctDNA), a small piece of DNA released from dying cancer cells into the blood (Photo courtesy of Jonathan Bailey).

Cancer DNA in Blood Helps Personalize Liver Cancer Treatment

Liver cancer tumor specimens are difficult and sometimes dangerous to obtain, and noninvasive methods are required to assess cancer progression and characterize underlying genomic features.  More...
15 Nov 2015
Image: Mucocutaneous papilloma manifestations around the nose of an autosomal dominant condition known as Cowden syndrome (Photo courtesy of University of Sao Paulo).

Predisposing Gene Associated With Cowden Syndrome

A new gene has been discovered that is associated with Cowden syndrome, an inherited condition that carries high risks of thyroid, breast, and other cancers, and a subset of non-inherited thyroid cancers.  More...
15 Nov 2015
Image: Molecular model of the prostate cancer drug abiraterone (Photo courtesy of Wikimedia Commons).

Analysis of Circulating DNA Predicts Prostate Cancer's Development of Drug Resistance

Analysis of prostate cancer DNA circulating in the bloodstream identifies a mutation that indicates whether the tumor will become resistant to the drug-of-choice abiraterone, and enables the physician to choose an alternative treatment.  More...
15 Nov 2015
Image: The QX200 AutoDG Droplet Digital polymerase chain reaction (ddPCR) dystem (Photo courtesy of Bio-Rad).

Molecular Technology Identifies Viral RNA Mutations in Clinical Samples

Droplet Digital polymerase chain reaction uses emulsion chemistry to partition nucleic acid samples into approximately 20,000 oil-encapsulated nanodroplets to produce data that surpasses the precision of other molecular methods with equivalent or much higher sensitivity.  More...
09 Nov 2015
Image: Histopathology of a testicular germ cell tumor consisting of teratoma, embryonal carcinoma yolk sac tumor and syncytiotrophoblasts (Photo courtesy of Lee Moffitt Cancer Center).

Four Susceptibility Loci Identified for Testicular Germ Cell Tumor

Testicular germ cell tumor is the most common cancer in men aged 15 to 45 years, with over 18,000 new cases diagnosed annually in Europe and the incidence of TGCT has approximately doubled over the last four decades in Western Europe, which implicates environmental or lifestyle factors as risk determinants.  More...
08 Nov 2015
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