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Molecular Diagnostics

Image: Researchers used microarrays to simultaneously measure concentrations of hundreds of molecules to identify relevant microRNA expression patterns that could help noninvasively diagnose breast cancer (Photo courtesy of the University Medical Center Freiburg).

Noninvasive Assay Developed for Breast Cancer Diagnosis from Urine

Researchers have pilot-tested the feasibility of detecting breast cancer-specific microRNA expression patterns in patient urine samples and have for the first time demonstrated a proof-of-principle for this novel gene-expression profile assay of BC-specific biomarkers in urine.   More...
17 Jun 2015
Image: The WPA-Biowave II Nano-spectrophotometer (Photo courtesy of Biochrom).

LAMP Technique Detects Toxoplasmosis

The analytical sensitivity and specificity of a newly described DNA amplification technique, loop-mediated isothermal amplification, has been tested for the diagnosis of toxoplasmosis.   More...
16 Jun 2015
Image: Histopathology of a biopsy smear from a patient with squamous cell carcinoma in the anal canal showing proliferation of atypical cells that infiltrate the stromal (Photo courtesy of Muñiz Hospital).

Biomarker Analysis Reveals Treatment Targets in Anal Cancer

Squamous cell anal carcinoma is a rare, human papillomavirus-associated malignancy accounting for 2% of digestive system cancers and usually these malignancies are detected early and successfully managed with chemoradiation.  More...
16 Jun 2015
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Ovarian Cancer-Specific Markers Leads to Early Diagnosis

While DNA carries all the instructions necessary for life, its actual sequence contains much more than just the genes that code for proteins, while in contrast messenger ribonucleic acids are complementary copies of just the genes.  More...
08 Jun 2015
Image: The HiSeq 2000 sequencing system (Photo courtesy of the University of Queensland).

Blood Test Detects Breast Cancer Metastasis Early

Cell‐free circulating tumor DNA contains tumor‐specific chromosomal rearrangements that may be interrogated in blood plasma and used to detect metastatic breast cancer earlier.   More...
03 Jun 2015
Image: Histopathology of thyroid colloid nodules displaying macrofollicles lined by flattened thyroid epithelial cells. The nodules are circumscribed and do not have a fibrous capsule (Photo courtesy of the University of Siena).

Genetic Mutation Test Improves Definitive Diagnosis of Thyroid Nodules

Cytopathology on ultrasound-guided fine needle aspiration biopsies has dramatically improved the clinical management of patients with solid thyroid nodules that are greater than one centimeter.   More...
03 Jun 2015
Image: Histopathology of Barrett\'s esophagus; the metaplasic epithelium of Barrett\'s esophagus is characterized by goblet cell, which stain blue with alcian blue (Photo courtesy of Nephron).

Molecular Test Predicts Cancer Risk of Barrett's Esophagus

A molecular diagnostic test has been developed for predicting risk of progression from Barrett's esophagus to esophageal cancer approximately three to four years before the cancer progresses.  More...
02 Jun 2015
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Genetic Testing channel of LabMedica brings the latest in molecular genetics, cytogenetics, and epigenetics, and methods from PCR to FISH, and more.