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Molecular Diagnostics

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Massively Parallel Gene Function Assays Reduce Genetic Diagnoses Ambiguity

Genetic tests increasingly use more comprehensive multi-gene and whole-genome sequencing methods and it is becoming more common for patients to learn they carry a variant of unknown significance.  More...
07 Jul 2015
Image: Histopathology of pancreatic adenocarcinoma arising in the pancreas head region (Photo courtesy of Dr. KGH/Wikimedia).

Multiple Genetic Changes Linked to Increased Pancreatic Cancer Risk

A genome-wide association study, believed to be the largest of its kind, has uncovered four regions in the human genome where changes may increase the risk of pancreatic cancer.   More...
06 Jul 2015
Image: Blood smear of child with acute lymphoblastic leukemia (Photo courtesy of Ohio State University).

Gene Mutation Identified That Can Trigger Lymphoblastic Leukemia

Some familial platelet disorders are associated with predisposition to leukemia, myelodysplastic syndrome or dyserythropoietic anemia.  More...
05 Jul 2015

Overexpression of X Chromosome Genes Is Biomarker for Female Mental Disorders

A recent paper suggested that elevated expression of the genes XIST and KDM5C could be used as a biological marker for diagnosis of major affective disorders in a significantly large subset of female patients from the general population.  More...
01 Jul 2015
Image: The CFX96 real-time polymerase chain reaction (PCR) detection system (Photo courtesy of Bio-Rad Laboratories).

Efficient Molecular Method Detects Pathogenic Leptospires

The diagnosis of leptospirosis, which primarily relies on antiquated serotyping methods, is particularly challenging due to presentation of non-specific symptoms shared by other febrile illnesses, often leading to misdiagnosis.   More...
29 Jun 2015
Image: Histopathology of an adenocarcinoma of the colon in which the glands are enlarged and filled with necrotic debris (Photo courtesy of Dr. Charanjeet Singh, MD).

Biomarkers Help Personalize Metastatic Colorectal Cancer Treatment

In patients with metastatic colon cancer, response to first line chemotherapy is a strong predictor of overall survival, but currently, oncologists lack diagnostic tests to determine which chemotherapy regimen offers the greatest chance for response in an individual patient.  More...
29 Jun 2015
Image:  The Wizard Genomic DNA Purification kit (Photo courtesy of Promega).

Gene Mutations Leave Patients Vulnerable to Severe Early Infections

A previously unknown genetic immunodeficiency linked to mutations in a gene deactivates many features of the immune system and leaves affected children open to a unique pattern of aggressive, potentially fatal infections early in life.   More...
29 Jun 2015
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Genetic Testing channel of LabMedica brings the latest in molecular genetics, cytogenetics, and epigenetics, and methods from PCR to FISH, and more.