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Molecular Diagnostics

Image: Colorized transmission electron micrograph (TEM) revealed some of the ultrastructural morphology displayed by an Ebolavirus virion with supplemented spermatozoa (Photo courtesy of Frederick A. Murphy/CDC, and Graphic by Mark Murrman).

Ebolavirus Found in Semen Months After Symptom Onset

The main mode of transmission is direct contact with the blood or body fluids of a person with Ebolavirus disease or from the body of a person who died from the disease; however, Ebolavirus can persist in the body fluids of survivors during convalescence, which may result in transmission of the virus.   More...
04 Nov 2015
Image: MinION USB-attachable miniature DNA sequencing device (Photo courtesy of Oxford Nanopore).

Miniature DNA Sequencing Device Independently Evaluated

The performance of a hand held miniature DNA sequencing device has been evaluated by an open, international consortium, and the resulting recommendations and protocols are available.   More...
04 Nov 2015
Image: New study shows that blood testing by targeted-NGS of extracted cfDNA could help match cancer patients with the most appropriate targeted therapy and to simply and quickly monitor response to treatment (Photo courtesy of Cancer Research UK).

Blood Test Could Match and Monitor Cancer Patients and Treatment

Researchers have found that new generation sequencing of circulating cell-free DNA in blood plasma could help successfully pair cancer patients with the most suitable therapy and track tumor progression to assess treatment effectiveness.  More...
01 Nov 2015
Image: The HiSeq 2500 ultra-high-throughput sequencing system (Photo courtesy of Illumina).

Novel Diagnostic Technology Rapidly Identifies Cancer Source

A substantial proportion of cancer cases present with a metastatic tumor and require further testing to determine the primary site; many of these are never fully diagnosed and remain cancer of unknown primary origin.  More...
28 Oct 2015
Image: The IONA test for the screening plasma for trisomies 21, 18 or 13 (Photo courtesy of Premaitha Health plc).

Noninvasive Prenatal Screening Test Validated for Trisomies

Diagnosis of fetal aneuploidies relies on invasive testing by chorionic villous sampling or amniocentesis in pregnancies that are identified by screening to be at high-risk for such aneuploidies.  More...
28 Oct 2015
Image: A schematic diagram of a new method that rapidly analyzes the RNA (green strands) of HIV for mutations (red dot) that convey drug resistance. The system does not require transcription of RNA to DNA, as current technologies do, and works within one solution (purple droplet) (Photo courtesy of Dr. Lei Zhang, Brown University).

One-Tube RNA Ligation and Amplification Method for Rapid Detection of Drug Resistant HIV

By not requiring transcription of RNA to DNA, a novel one-tube method allows the rapid detection of drug resistant strains of HIV.  More...
28 Oct 2015
Image: The 3M Integrated Cycler with assay kits (Photo courtesy of Focus Diagnostics).

Simplexa Direct Test Includes 53 New Virus Strains

The Simplexa test kit for select virus strains can detect a total of 92 influenza and respiratory syncytial virus virus strains, more than any other officially cleared molecular test kit.  More...
20 Oct 2015
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Genetic Testing channel of LabMedica brings the latest in molecular genetics, cytogenetics, and epigenetics, and methods from PCR to FISH, and more.
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