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Clinical Chemistry

Image: Ribbon representation of the human cardiac troponin core complex in the calcium-saturated form. Blue = troponin C; green = troponin I; magenta = troponin (Photo courtesy of Dr. Lauren Ann Metskas).

Limited Cardiac Biomarker Testing Decreases Health Care Costs

Two relatively simple tactics have been used to significantly reduce the number of unnecessary blood tests to assess symptoms of heart attack and chest pain and to achieve a large decrease in patient charges.  More...
15 Jul 2014
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Simple New Method Identifies Food Allergies

A highly-sensitive method has been developed that can quickly and accurately identify proteins that cause allergic reactions even at very low concentrations.  More...
14 Jul 2014

Acute Kidney Injury and Chronic Kidney Disease Closely Entwined

Common risk factors of acute kidney injury and chronic kidney disease include advanced age, diabetes, and high blood pressure.   More...
13 Jul 2014

Novel Miniature Mass Spectrometer Moves Cocaine Measurement to the Field

A novel device for field testing of cocaine and other drugs comprises a portable mass spectrometer and a system for rapid drying and extracting urine samples.   More...
07 Jul 2014
Image: Histopathology of non-alcoholic fatty liver disease showing the liver with prominent macrovesicular steatosis (Photo courtesy of Nephron).

Liver Values Elevated in Overweight Children with Gene Mutation

Genetic polymorphism has been strongly associated with liver fat content and plasma alanine aminotransferase levels in obese adults and children, but little is known about these relationships in normal weight individuals.  More...
07 Jul 2014
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Ultra-Performance LC-MS System Approved for Clinical Applications in China

An ultra-performance liquid chromatography – mass spectrometry system has been approved by the Chinese Food and Drug Administration as a medical device for routine diagnostic applications and for screening of neonatal metabolites diseases.   More...
03 Jul 2014
Image: The Applied Biosystem Veriti Thermal Cycler (Photo courtesy of Life Technologies).

High-Risk Female Groups Screened for Fabry Disease

Although measurement of lysosomal α-galactosidase A in women is not accurate for the diagnosis of Fabry disease, determining the range of the enzyme activity presented by heterozygous females could become a valuable tool for minimizing the burden of screening by DNA sequencing all potential carriers.   More...
26 Jun 2014
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The Clinical Chemistry channel updates the reader on tests, techniques, and research in the field - from routine assays to specialized tests on blood, urine, enzymes, lipids, hormones and more.