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Clinical Chemistry

Image: Newly designed bacteria with synthetically rewired genetic circuitry act as bactosensors to detect abnormal glucose levels in urine of diabetes patients (Photo courtesy of Chris Bickel and the journal Science).

Next-Generation Whole-Cell Biosensors May Provide New Approach to Diagnostics

Researchers have developed the first programmable bacterial cells for medical diagnosis with improved computing and amplification capacity that could enable earlier clinical detection of various pathological biomarkers in urine or blood.  More...
08 Jun 2015
Image: The centrifugation step is the key to removing protein biomarkers from urine\'s high salt matrix (Photo courtesy of Clemson University).

Rapid Extraction Technique Prepares Urine Samples for Mass Spectrometry Analysis

Disposable mini-tubes packed with capillary-channeled polymer fibers have been adapted for the rapid extraction of proteins from urine specimens for analysis by MALDI-MS.  More...
07 Jun 2015
Image: Computed tomography scan (CT) of a patient with brain trauma showing cerebral contusions, hemorrhage within the hemispheres, subdural hematoma, and skull fractures (Photo courtesy of Drs. T. Rehman, R. Ali, I. Tawil, and H. Yonas).

Blood Test Detects Traumatic Brain Injury Reducing Unnecessary Imaging

A simple blood test to measure brain-specific proteins released after a person suffers a traumatic brain injury can reliably predict both evidence of TBI on radiographic imaging and injury severity.  More...
02 Jun 2015
Image: Cxbladder kit, for the noninvasive laboratory test for the detection of bladder cancer (Photo courtesy of Peter Wren-Hilton).

Molecular Test Stratifies Patients with Bladder Cancer Symptoms

A urine-based molecular diagnostic combines clinical risk factors and gene expression biomarkers to accurately triage patients presenting with blood in their urine who have a low probability of urothelial cancer.  More...
01 Jun 2015
Image: Histopathology of a prostate biopsy showing normal prostatic glands and glands of prostate cancer prostate adenocarcinoma in right upper aspect of image (Photo courtesy of Nephron).

Urine-Based Test Improves Detection of Prostate Cancer

A new urine-based test improved prostate cancer detection, including detecting more aggressive forms of prostate cancer, compared to traditional models based on prostate serum antigen, or PSA, levels.   More...
01 Jun 2015
Image: Professor Emeritus David Lawrence Sackett, MD (Photo courtesy of McMaster University).

Professor Emeritus David L. Sackett, Developer of Evidence Based Medicine

Professor Emeritus David Lawrence Sackett, MD, widely regarded as the father of evidence based medicine, died on May 13, 2015, in Canada.  More...
01 Jun 2015
Image: The CARY 50 BIO UV-Visible Spectrophotometer (Photo courtesy of Agilent Technologies).

Harmless Bacteria Thrive in Patients with Inflammatory Bowel Disease

The survival and proliferation of usually harmless Escherichia coli in the gut of inflammatory bowel disease patients may now be better understood, as fundamental mechanism through which the bacteria can thrive during flare-ups has been defined.  More...
26 May 2015
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The Clinical Chemistry channel updates the reader on tests, techniques, and research in the field - from routine assays to specialized tests on blood, urine, enzymes, lipids, hormones and more.
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