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Clinical Chemistry

Image: The Olympus AU680 automated analyzer (Photo courtesy of Beckman Coulter).

HDL Subclasses Linked to Mortality in Heart Failure Patients

Heart failure (HF) is a frequent cause of morbidity and mortality worldwide and is defined by the as an abnormality of the cardiac structure and function, resulting in a diminished ability of the heart to maintain optimal perfusion of metabolizing tissues. More...
11 Feb 2019
Image: An increase in fasting blood glucose level increases the risk of cardiovascular disease (Photo courtesy of Diabetes Self Care).

Long-Term Risk for CVD Stratified by Fasting Glucose Level

Cardiovascular disease (CVD) refers to any disease of the heart, vascular disease of the brain, or disease of the blood vessel. The most prevalent cardiovascular diseases include coronary heart disease (CHD) such as a heart attack and cerebrovascular disease such as a stroke. More...
31 Jan 2019
Image: New research suggests that high-sensitivity C-reactive protein test is underutilized (Photo courtesy of Bluehorizon).

High-Sensitivity CRP Testing Underutilized

Heart attack, stroke, and atherothrombotic cardiovascular deaths are disorders characterized by chronic hyperlipidemia in the setting of a persistent pro-inflammatory response, often exacerbated by hypertension and behavioral factors such as smoking. More...
29 Jan 2019
Image: High magnification micrograph of a renal oncocytoma. The tumor cells (left of the image) are arranged in nests, have slightly enlarged nuclei and have a more eosinophilic (darker pink) cytoplasm than the normal kidney - renal tubules (right of image) (Photo courtesy of Nephron).

Retina Protein Antibodies Used As Kidney Cancer Marker

Renal cell carcinoma (RCC) is the second-most common uronephrological cancer. In the absence of specific symptoms, early diagnosis of RCC is challenging. Monitoring of the aberrant expression of tumor-associated antigens (TAAs) and related autoantibody response is considered as a novel approach of RCC diagnostics. More...
28 Jan 2019
Image: Testing blood glucose regularly allows for glycemic control strategy (Photo courtesy of the American Academy of Family Physicians).

Biochemical Hypoglycemia Associated with Risk of Hypoglycemia

To optimize diabetes management, it is essential to have assessments of both hyperglycemia and hypoglycemia. Glycated hemoglobin (HbA1c) is primarily a measure of hyperglycemia, but it provides no indication of the frequency or severity of hypoglycemia. More...
24 Jan 2019
Image: The Calprolab enzyme-linked immunosorbent assay (ELISA ALP) test kit for calprotectin estimation (Photo courtesy of Calpro).

Calprotectin Independently Predicts Relapse in Treated RA

Calprotectin is a biomarker of disease activity in rheumatoid arthritis (RA) and psoriatic arthritis (PsA) and predicts relapse in juvenile idiopathic arthritis. Higher drug trough serum levels are associated with a good response in patients treated with tumor necrosis factor inhibitors (TNFi). More...
14 Jan 2019
Image: The AU 5800 automatic analyzer (Photo courtesy of Beckman Coulter).

Fructosamine Reference Range Established for Brazil

Traditional markers used in diabetes diagnosis and monitoring include fasting plasma glucose (FPG), two-hour plasma glucose (2-hPG) measured during the oral glucose tolerance test (OGTT), and glycated hemoglobin (HbA1c) levels. More...
14 Jan 2019
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The Clinical Chemistry channel updates the reader on tests, techniques, and research in the field - from routine assays to specialized tests on blood, urine, enzymes, lipids, hormones and more.
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