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BioResearch

Image: The Mseek technique uses enzymes to purify mitochondrial DNA by deleting the nuclear DNA, leaving behind the pure mitochondrial DNA to be sequenced (Photo courtesy of the Middle East Molecular Biology Society).

New Tool Facilitates Study of Mitochondrial DNA Variation

A new tool has been developed that enables researchers to study mitochondrial heteroplasmy and which will aid them in achieving better understanding of its impact on health and disease.  More...
17 Mar 2015
Image:  Model depiction of a novel cellular mechanism by which regulation of cryptochromes Cry1 and Cry2 enables coordination of a protective transcriptional response to DNA damage caused by genotoxic stress (Photo courtesy of the journal eLife, March 2015, Papp SJ, Huber AL, et al.).

Two Proteins Critical for Circadian Cycles Protect Cells from Mutations

Scientists have discovered that two proteins critical for maintaining healthy day-night cycles also have an unexpected role in DNA repair and protecting cells against genetic mutations that could lead to cancer and other diseases.   More...
17 Mar 2015
Image: TEM (transmission electron micrograph) of a mesoporous silica nanoparticle (Photo courtesy of Wikimedia Commons).

Silica-Based Nanoparticles Selectively Kill Lung Cancer Cells

A novel approach to the selective delivery of toxic chemotherapeutic agents is based on nanoparticles that sequester the drug until it is liberated by the action of specific proteases that are present in a high concentration inside lung cancer cells.  More...
16 Mar 2015

Experimental Brain Cancer Drug Disrupts Intracellular Endosome Activity

Cancer researchers have described the mechanism by which the low molecular weight compound 5-Benzylglycinyl-amiloride disrupts the internal regulation of brain cancer cells in a manner that triggers the pathway for programmed cell death.   More...
16 Mar 2015
Image: Photomicrograph of mouse embryonic cells that have been programmed to overexpress Higd1a protein (shown in green). This protein slows down the metabolism of cancer cells, allowing them to hibernate and survive long-term (Photo courtesy of the University of California, San Francisco).

Oxygen Deprivation Activates Tumor Survival Genes in Solid Tumors

A possible new approach for treating reoccurring tumors would target the protein hypoxia-inducible gene domain family member 1A.  More...
15 Mar 2015
Image: Blood smear from a P. falciparum culture. Several red blood cells have ring stages inside them. Close to the center is a schizont and on the left a trophozoite (Photo courtesy of Wikimedia Commons).

Long Noncoding RNAs Maintain Antigenic Variation in the Malaria Parasite

Control of DNA expression by long noncoding RNAs has been found to underlie antigenic variation, the mechanism by which the malaria parasite Plasmodium falciparum maintains its virulence and evades human immune attack.  More...
11 Mar 2015
Image: In the new method for building nanotubes, blocks tagged with a fluorescent dye are incorporated step by step, enabling researchers to monitor formation of the structures as they are constructed (Photo courtesy of Dr. Graham D. Hamblin, McGill University).

New Study Details the Block by Block Assembly of DNA Nanotubes

A team of biomolecular engineers has developed a method for the block by block assembly of DNA nanotubes that controls the positioning of rungs along the backbone of the nanotubes, minimizes the polydispersity in their manufacture, and reduces the building costs.  More...
10 Mar 2015
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BioResearch brings the latest research news on the genome, proteome, metabolome, on drug discovery, and therapeutics. Biotech researchers, lab administrators, technologists, drug manufacturers, and suppliers can find the latest research news and information related to their fields of endeavor here.