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BioResearch

Image: Renal proximal tubule-like cells (nucleus: blue, cytoplasm: red) derived from induced pluripotent stem cells that have been left untreated (top) or treated with aristolochic acid (bottom), an herbal nephrotoxic compound widely used in traditional Chinese medicine and other herbal remedies, which is now banned in many countries. (Photo courtesy of Singapore’s Institute of Bioengineering and Nanotechnology).

First Animal-Free Screening Platforms to Predict Toxic Kidney Injury

In a biotechnological advancement involving human induced pluripotent stem cells, researchers have developed the first animal-free screening platforms capable of predicting a compound’s toxicity on the human kidney. The new platforms may provide a reliable and efficient tool in evaluating safety of novel compounds and ingredients, as is required in chemical and pharmaceutical as well as food and consumer care industries.  More...
18 Oct 2015
Image: A Vetter aseptically pre-filled syringe (Photo courtesy of Vetter).

German Prefilled Syringe Manufacturer to Double Production Capability

A major manufacturer of pre-filled sterile syringes, cartridges, and vials will be investing approximately EUR 300 million to expand and upgrade its manufacturing facilities over an estimated five-year period.  More...
18 Oct 2015
Image: Melanin pigment (light refracting granular material – center of image) in a pigmented melanoma (Photo courtesy of Wikimedia Commons).

Exposure to Antioxidants Accelerates Malignant Melanoma Metastasis

Antioxidants, which had been shown previously to stimulate lung cancer growth, have now been found to accelerate metastasis of malignant melanoma.  More...
14 Oct 2015
Image: On the left is the schematic design of the TRAIL/Dox loaded platelet membrane-coated nanogel delivery system. The TRAIL is attached on the surface of membrane and Dox is loaded in the core of nanogel. On the right is a transmission electron microscope image of the drug delivery system. Black is the synthetic core nanogel, the outside shell is the platelet membrane (Photo courtesy of Quanyin Hu, joint biomedical engineering program at North Carolina State University and the University of North Carolina).

Nanovesicles Coated with Platelet Membranes Target Cancer Cells and Reduce Doxorubicin Toxicity

A novel delivery system for the toxic chemotherapeutic drug doxorubicin utilizes nanovesicles coated with extracted platelet membranes and the cytokine TRAIL.  More...
14 Oct 2015
Image: Micrograph of an inflamed fatty liver. White indicates areas of fat; red are hepatocytes or liver cells. Bluish areas are fibrotic strands (Photo courtesy of Dr. James Heilman).

Twins Study Reveals Fatty Liver Disease Heritability

A study involving identical and fraternal twins showed that incidence of fatty liver disease was equivalent for the identical twins but not correlated among the fraternal twins, suggesting that the syndrome might be inherited.  More...
13 Oct 2015
Image: Schematic representation of HIV DART binding to two distinct antigens simultaneously, redirecting the killer T-cells to destroy HIV-1 infected cells (Photo courtesy of Duke University).

Bi-Specific Antibodies Shown to Clear Latent HIV Infections

Bi-specific antibodies or DARTS have been used to eliminate latent HIV-infection from patient samples by redirecting polyclonal T-cells to specifically engage with and kill HIV-infected cells that display HIV antigens on their cell membranes.  More...
12 Oct 2015
Image: Molecular model of the dystrophin protein (Photo courtesy of Wikimedia Commons).

Novel Gene Therapy Treatment Extends Life of Mice Severely Affected by Muscular Dystrophy

An alternative gene therapy approach was used to successfully treat a mouse model of Duchenne muscular dystrophy.  More...
11 Oct 2015
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BioResearch brings the latest research news on the genome, proteome, metabolome, on drug discovery, and therapeutics. Biotech researchers, lab administrators, technologists, drug manufacturers, and suppliers can find the latest research news and information related to their fields of endeavor here.
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