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Image: The micrographs show the synapses between motor neurons and muscle that are normal in control mice (top). In mice lacking the microRNA molecule miRNA-218, neuromuscular junctions are severely defective and motor neurons undergo neurodegeneration (bottom). Pre-synaptic motor axons are in green, and post-synaptic acetylcholine receptors expressed by muscle are in red. Areas of overlap in yellow identify correctly formed neuromuscular junctions (Photo courtesy of the Salk Institute for Biological Sciences).

MicroRNA Defect Triggers Motor Neuron Disease Symptoms in Mouse Model

A team of neurobiologists working with a mouse model has shown how the loss of a single microRNA caused newborn mice to die at birth while exhibiting symptoms of neuromuscular junction defects similar to those seen in human motor neuron diseases.  More...
28 Dec 2015
Image: The image depicts a three-dimensional model of the protein complex mTORC1 (Photo courtesy of the University of Basel).

Researchers Present Definitive Molecular Structure of mTORC1

By combining cryoelectron microscopy with X-ray crystallographic data, researchers have been able to define the structural architecture of the protein complex mTORC1.  More...
27 Dec 2015

FDA-Approved Medications with Antibiotic Activity

From a new study, a number of drugs approved by the US Federal Drug Administraion to treat cancers, parasitic infections, infertility, or other conditions have been found also to have antibiotic properties.  More...
27 Dec 2015

Joint Venture Formed to Commercialize CRISPR/Cas9 Gene-Editing Technology

An agreement has been signed creating a joint venture to enable biopharmaceutical partners to commercialize and explore new uses for CRISPR-Cas9 gene-editing technology.  More...
27 Dec 2015
Image: Secondary structure and sequence conservation of the microRNA miR-205 (Photo courtesy of Wikimedia Commons).

MicroRNAs Regulate Response to Chronic Viral Infections

To study the role of microRNAs in the cellular response to virus infection, researchers generated a vector that rapidly eliminated total cellular miRNA.  More...
23 Dec 2015
Image: The image on the left shows high-grade aggressive prostate cancer before treatment. The image on the right shows no evidence of cancer after combined gene therapy and radiotherapy (Photo courtesy of the Houston Methodist Hospital).

Combined Gene and Radiation Therapy Induces Long-Term Prostate Cancer Remission

Results of a Phase II clinical trial indicated that an experimental gene therapy approach could successfully induce remission of prostate cancer when it was combined with directed radiation treatment.  More...
22 Dec 2015
Image: Gram-stained Bacillus subtilis bacteria (Photo courtesy of Wikimedia Commons).

Bacterial Cytological Profiling Streamlines Search for New Antibiotics

Bacterial cytological profiling is a rapid screening technique for identifying and characterizing new antibiotic compounds from mixtures of natural products. More...
22 Dec 2015
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BioResearch brings the latest research news on the genome, proteome, metabolome, on drug discovery, and therapeutics. Biotech researchers, lab administrators, technologists, drug manufacturers, and suppliers can find the latest research news and information related to their fields of endeavor here.
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