BioResearch
Proteasome-Activating Drug Reverses Neurodegenerative Disease Symptoms in Mouse Model
Accumulation of insoluble tau protein complexes, which characterizes several types of neurodegenerative diseases, was associated with a decrease in brain proteasome peptidase activity that could be restored by treatment with a phosphodiesterase-4 inhibitor drug. More...06 Jan 2016
Maintenance of a Stable Karyotype Depends on Action of a Long Noncoding RNA
A long noncoding RNA regulates cellular genomic stability by sequestering the PUMILIO proteins, which would otherwise drive chromosomal instability by repressing mitotic, DNA repair, and DNA replication factors. More...05 Jan 2016
Loss of Long Noncoding RNA Inhibits Breast Tumor Metastasis in Mouse Model
Blocking the activity of a single long noncoding RNA in malignant breast cancer mouse models transformed aggressive cancers into slow growing cyst-like tumors and reversed the metastatic process by up to 70%. More...
05 Jan 2016
Inhaled Viral Capsids Trigger Systemic Antitumor Response in Mouse Model
The shells of deactivated Cowpea mosaic virus were found have potent adjuvant activity on cancer growth, which was demonstrated by the ability to block immune system suppression in the tumor microenvironment and subsequently to trigger a full-blown systemic antitumor immune response. More...04 Jan 2016
Maple Syrup Compound a Potent Anti-Inflammatory Agent
A substance that forms during the process that renders maple sap into syrup was found to have potent anti-inflammatory properties that may be developed into drugs for treatment of diseases characterized by chronic inflammation such as arthritis. More...04 Jan 2016
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In Other News
Cytoplasmic Polyadenylation Element-Binding Proteins Regulate Pathologic Angiogenesis in Chronic Liver Diseas
Modification of Integrin Ligand Receptors May Lead to Personalized Cancer Diagnosis and Treatment
Nanobridges Transport Pro-Metastatic MicroRNAs from Cancer Cells to Surrounding Normal Tissues
Multiple Copies of RNA Editing Enzyme Gene Promote Lung Cancer Growth
Small Molecule Innate Immune System Stimulators Show Promise as Broad-Spectrum Antiviral Drugs
Blocking a Long Noncoding RNA Reduces Stroke Damage in Rat Model
Structure of Bacterial Polysaccharide Synthesizing Enzyme May Lead to New Drugs
MicroRNA Defect Triggers Motor Neuron Disease Symptoms in Mouse Model
Researchers Present Definitive Molecular Structure of mTORC1
FDA-Approved Medications with Antibiotic Activity
Joint Venture Formed to Commercialize CRISPR/Cas9 Gene-Editing Technology
MicroRNAs Regulate Response to Chronic Viral Infections
Combined Gene and Radiation Therapy Induces Long-Term Prostate Cancer Remission
Bacterial Cytological Profiling Streamlines Search for New Antibiotics
Nanoparticle-Delivered Drug Cocktail Blocks Spread of Malignant Melanoma Through the Lymph System
Fucose Metabolism Linked to Tendency of Melanomas to Metastasize
Combined Stem Cell and Hormonal Therapy Stimulates Bone Growth and Repair
Monoclonal Antibody Treatment Decreases Severity of Whooping Cough in Animal Models
First Add-On Module Automates Cloning of DNA Sequences
SecA Inhibitors Block Growth of Methicillin-Resistant Staphylococcus aureus
Development of Neurodegenerative Diseases Linked to Astrocyte Nitric Oxide Signaling
Viscoelastic Hydrogels Promote Bone Formation in 3D Cell Cultures
Drugs That Block Sulfur Metabolism Show Potential for Treating Latent Tuberculosis
BioResearch brings the latest research news on the genome, proteome, metabolome, on drug discovery, and therapeutics. Biotech researchers, lab administrators, technologists, drug manufacturers, and suppliers can find the latest research news and information related to their fields of endeavor here.
