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BioResearch

Image: Human breast cancers (blue) grown on mice show marked reductions in inflammatory cytokines such as IL1a and IL6 (yellow) when MLL1 is inhibited (Photo courtesy of Dr. Brain Capell, University of Pennsylvania).

Global Regulator of Gene Transcription Identified as Potential Anticancer Drug Target

The enzyme MLL1 was identified as a potential target for anticancer drugs after researchers found that its inhibition prevented tumor development by shutting down the DNA damage response mechanism and suppressed inflammation by blocking the activity of proliferation-promoting genes.  More...
14 Feb 2016
Image: A metastasis now growing in lung tissue (blue) that originated from at least two cells (red and green) from a multicolored tumor in the mammary gland of a mouse (Photo courtesy of Breanna Moore, Cheung laboratory, Fred Hutchinson Cancer Research Center).

Polyclonal Breast Cancer Metastases Are Generated by Clusters of Migrating Cells

A recent study confirmed that, contrary to conventional wisdom, cancer metastasis usually depends on the release of clusters of cells rather than single cells from the primary tumor.  More...
14 Feb 2016

Expanded Collaboration Agreement Intended to Accelerate Development of Anticancer T-cell Immunotherapeutics

Two British biotechnology companies have expanded their strategic collaboration in order to accelerate development of anticancer therapies based on T-cell immunotherapy.  More...
14 Feb 2016
Image: Schematic diagram of dendrimer structure (Photo courtesy of the University of California, Irvine).

Dendrimer-Transported MicroRNA Shown Effective in Treating Mice with Late-Stage Liver Cancer

Cancer researchers have used nanocarriers called dendrimers to transport a specific tumor growth-inhibiting microRNA to the livers of mice with late-stage liver cancer.  More...
10 Feb 2016
Image: Open fruit of the achiote tree (Bixa orellana), showing the seeds from which annatto is extracted (Photo courtesy of Wikimedia Commons).

Annatto Component Prevents UV Damage and Prevents Skin Cancer in Mouse Model

The apocarotenoid compound bixin is a widely consumed food additive that was shown in a recent paper to have potent antioxidant properties, which prevented the formation of cancer cells and skin damage from UV radiation in a mouse model.  More...
09 Feb 2016
Image: Copper, zinc superoxide dismutase (Cu Zn SOD) is essential to life, but when damaged can become toxic (Photo courtesy of Oregon State University).

Novel Copper Therapy Cures ALS Mouse Model

Selective delivery of copper to the central nervous system effectively treats the motor neuron disease amyotrophic lateral sclerosis in the most widely used mouse model of the disorder.   More...
09 Feb 2016
Image: Top: Overview of the structure of T-STAR STAR domain in complex with AUUAAA RNA. Bottom left: close up view of the specific recognition of the RNA. Bottom right: close up view of the KH dimerization interface (Photo courtesy of the University of Leicester).

Atomic Structures of Alternative Splicing Regulator Proteins May Lead to New Anticancer Drugs

A detailed structural analysis of two RNA-binding proteins that regulate alternate splicing of gene expression, which can lead to various types of cancer, is expected to aid in the development of drugs to suppress this activity.  More...
08 Feb 2016
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BioResearch brings the latest research news on the genome, proteome, metabolome, on drug discovery, and therapeutics. Biotech researchers, lab administrators, technologists, drug manufacturers, and suppliers can find the latest research news and information related to their fields of endeavor here.