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BioResearch

Image: Researchers used a model blood vessel system built into a polymer microchip to study the activity of white blood cells as they were affected by drugs that tend to make them softer, which facilitates their entry into blood circulation (Photo courtesy of Rob Felt, Georgia Institute of Technology).

Physical Considerations Regulate Leukocyte Motion in the Circulatory System

A team of biomedical engineers constructed a model circulatory system within a polymer microchip, creating a tool that enabled them to show that the relative hardness or softness of white blood cell leukocytes determined whether they clung to the edges of blood vessels or circulated freely with the blood.  More...
23 Feb 2016
Image: Structure of LDL (low-density lipoprotein) (Photo courtesy of MP Biomedicals).

LDL-DHA Nanoparticles Selectively Eradicate Liver Tumors in Rat Model System

Uptake of low-density lipoprotein particles loaded with the omega-3 fatty acid docosahexaenoic acid by liver cancer cells resulted in destruction of established tumors in a rat liver cancer model.  More...
22 Feb 2016
Image: T-cell acute lymphoblastic leukemia (T-ALL), a cancer that strikes primarily in childhood, can only survive and grow when sent a signal from neighboring cells called dendritic cells (shown in green) in the tumor\'s near environment (Photo courtesy of the University of Texas, Austin).

Molecular Signals from Neighboring Dendritic Cells Drive Leukemia Growth

Noncancerous cells in the immediate tumor microenvironment supply signals that drive T-cell acute lymphoblastic leukemia growth, and may become attractive therapeutic targets to control the disease.   More...
22 Feb 2016
Image: A neem tree – Azadirachta indica (Photo courtesy of Wikimedia Commons).

Neem Tree Extract Halts Pancreatic Cancer Growth in Mouse Models

Nimbolide, a compound extracted from the leaves of the neem tree  - Azadirachta indica, was shown in culture and mouse models to have potential as a chemotherapeutic agent for the treatment of pancreatic cancer.  More...
21 Feb 2016
Image: Callosal projection neurons (green) are shown in the cerebral cortex (Photo courtesy of Dr. Jessica MacDonald and Dr. Jeffrey Macklis, Harvard University).

Reducing NF-KappaB Signaling Ameliorates Neurological Symptoms in Rett Syndrome Mouse Model

By tracing the molecular pathway linked to the neurological disorder Rett syndrome, researchers have identified molecular pathway that seems to be a potential drug target for alleviating symptoms of the condition.  More...
21 Feb 2016

Partners to Develop and Commercialize New Cancer Therapeutic Drugs

German and French biopharmaceutical companies have agreed to cooperate in the development and commercialization of new cancer therapeutics based on drugs that eliminate cancer cells by activating the TLR3 pathway.  More...
21 Feb 2016
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New Line of Highly Accurate Pipettes Easy to Use and Maintain

A new line of mechanical pipettes offers biotech, life science, and clinical lab technicians a precision laboratory tool with a high degree of accuracy and reliability that is also safe, comfortable, and easy to use.  More...
17 Feb 2016
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BioResearch brings the latest research news on the genome, proteome, metabolome, on drug discovery, and therapeutics. Biotech researchers, lab administrators, technologists, drug manufacturers, and suppliers can find the latest research news and information related to their fields of endeavor here.
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