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BioResearch

Image: A model of the structure of the SIRT5 protein (Photo courtesy of Wikimedia Commons).

Cardiomyopathy Linked to Faulty Regulation of Heart Protein Succinylation

The enzyme SIRT5, also known as sirtuin (silent mating type information regulation 2 homolog) 5, was found to play a critical role in maintaining healthy cardiac function by regulating the lysine succinylation modification of heart cell proteins. More...
28 Apr 2016

Huge Modifiable Biomedical Database to Be Available on the Wikidata Site

Genome researchers are exploiting the power of the open Internet community Wikipedia database to create a comprehensive resource for geneticists, molecular biologists, and other interested life scientists. More...
28 Apr 2016
Image: A confocal fluorescence microscopy image of NLRX1 (green) in a HeLa cell (blue, nuclear stain) (Photo courtesy of Dr. Haitao Guo, University of North Carolina).

A Host Protein Interferes with the Immune System's Ability to Deal with DNA Viruses

A team of molecular immunologists has identified a human protein that interferes with the ability of the immune system to ward off infections caused by viruses such as HIV. More...
27 Apr 2016
Image: The DFC9000 sCMOS microscope camera mounted to a DMi8 inverted microscope (Photo courtesy of Leica Microsystems).

Next-generation sCMOS Microscope Cameras Offer High Resolution Live Cell Imaging

A new generation of microscope cameras enables investigators to obtain images of living cells under near-native conditions. More...
27 Apr 2016
Image: High expression of COMP in breast cancer cells, seen here in brown, was associated with poor clinical prognosis for the patient. Cancer cells expressing COMP became more invasive and changed their metabolism, which allowed them to survive better and spread to other organs (Photo courtesy of Dr. Anna Blom, Lund University).

Growth and Spread of Breast Cancer Linked to Tumor Cells' Expression of a Cartilage Protein

A team of Swedish cancer researchers has identified a protein in breast tumors and surrounding stromal tissue that contributes to the development and spread of the disease. More...
27 Apr 2016
Image: Altered caudal fin morphology following paclitaxel injection into larval zebrafish at 2 dpf. (A) Morphological changes (arrows) in the fin fold 1 hour after injection with 10 µM paclitaxel (insets show higher magnification). (B) Fin damage (arrows) 3 hour after paclitaxel injection. (C) Vehicle controls with undamaged fins 4 hour postinjection. (Scale bar, 200 µm.) hpinj = hours postinjection. (Image courtesy of Lisse TS et al, 2016, PNAS.)

Study Identifies Mechanism Underlying a Form of Sensory Nerve Damage

Researchers have discovered a mechanism that underlies induction of peripheral neuropathy (PN) by the chemotherapeutic agent paclitaxel, raising the prospects for developing treatments for this and possibly also for certain other forms of PN. The work may also lead to companion diagnostics to identify patients who would benefit from these new therapies. More...
27 Apr 2016
Image: A micrograph of eosinophilic esophagitis (EoE), H&E stain. Characteristic features are present: Abundant eosinophils—criteria vary; one common definition is: > 20 eosinophils/0.24 mm2; Papillae are elongated; papillae reach into the top 1/3 of the epithelial layer; Basal cell hyperplasia; > 3 cells thick or >15% of epithelial thickness; Spongiosis (Photo courtesy of Wikimedia).

Pathway Implicated in Development of Eosinophilic Esophagitis

Scientists have identified a protein whose dysfunction appears to be involved in causing the tissue damage in patients with eosinophilic esophagitis (EoE). The finding may lead to improved pathology analysis, diagnostics, and specific drug therapies for patients. More...
26 Apr 2016
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BioResearch brings the latest research news on the genome, proteome, metabolome, on drug discovery, and therapeutics. Biotech researchers, lab administrators, technologists, drug manufacturers, and suppliers can find the latest research news and information related to their fields of endeavor here.
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