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BioResearch

Image: A high magnification (15,549x) scanning electron micrograph (SEM) showing a number of Gram-positive Mycobacterium tuberculosis bacteria (Photo courtesy of the CDC).

Cholesterol Analogs Block Growth of Tuberculosis Bacteria

Analogs of cholesterol that have been modified by the addition of non- degradable side chains have been shown to inhibit the growth of Mycobacterium tuberculosis, the bacterium that causes tuberculosis (TB).  More...
21 Apr 2016
Image: A cutaway illustration of the nanogel drug delivery system. The small particle can carry multiple drug agents to a specific target, such as the site of a tumor (Photo courtesy of Nicolle Rager Fuller, [US] National Science Foundation).

Novel Nanogel Drug Delivery System to Undergo Preliminary Clinical Trials

A novel nanogel drug delivery system designed to deliver multiple drugs with different chemical properties is to be tested in a first phase of clinical trials.  More...
21 Apr 2016

Drug Company Buyout to Boost Development of Liver Disease Drugs

A strategic buyout will broaden the role of an American pharmaceutical research and manufacturing company in the area of liver diseases.
 
 
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20 Apr 2016
The Titan Krios cryo-electron microscope is designed for use in protein and cellular imaging applications (Photo courtesy of FEI).

Cryo-EM Techniques to Be Exploited by UK-Based Research Consortium

A consortium has been formed to optimize the use of advanced cryo-electron microscopy techniques and to pool knowledge to promote the use of the instrument for research in structural biology and drug development. More...
19 Apr 2016

Review Promotes Use of Clinical Exome Sequencing for Diagnosis of Neurological Diseases

A recent review discussed the potential role of clinical exome sequencing for diagnosis of neurological diseases, focusing on the benefits to patients, limitations of the technique, appropriate use, and costs. More...
18 Apr 2016
Image: The particles start out relatively large (about 100 nanometers) to enable smooth transport into the tumor through leaky blood vessels. Then, in acidic conditions found close to tumors, the particles discharge “bomblets” just five nanometers in size. Inside tumor cells, a second chemical step activates the platinum-based drug cisplatin (Photo courtesy of Emory University).

Smart Nanoparticle Drug Delivery System Avoids Tumor-Protecting Obstacles

As a clearer image of the tumor microenvironment emerges, nanoparticle drug transport systems have evolved to overcome obstacles that prevent effective delivery of the chemotherapeutic agent.  More...
13 Apr 2016
Image: Space-filling model showing the crystallographic structure of the ligand binding domain of the ROR-gamma (receptor–related orphan receptor gamma) protein (Photo courtesy of Wikimedia Commons).

Indirect Inhibition of Overexpressed Androgen Receptor Activity Halts Growth of Castration-Resistant Prostate Cancer

Cancer researchers have shown that by suppressing the nuclear receptor protein ROR-gamma with small-molecule compounds they could reduce androgen receptor levels in castration-resistant prostate cancer and stop tumor growth.  More...
13 Apr 2016
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BioResearch brings the latest research news on the genome, proteome, metabolome, on drug discovery, and therapeutics. Biotech researchers, lab administrators, technologists, drug manufacturers, and suppliers can find the latest research news and information related to their fields of endeavor here.