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BioResearch

Image: An artist\'s rendition of the chromatin-nucleosome complex composed of DNA and histones. Polycomb-group proteins can remodel chromatin such that epigenetic silencing of genes takes place (Photo courtesy of Wikimedia Commons).

Mouse Model Advances Drug Development for Treating Lymphoma and Melanoma

Cancer researchers have established a mouse model system to study the involvement of EZH2 histone methyltransferase (EZH2) mutations in the development of lymphoma and melanoma tumors. More...
02 Jun 2016
Image: A three-dimensional rendering of a fluorescence image maps the piconewton forces applied by T-cells. The height and color indicates the magnitude of the applied force (Photo courtesy of Yang Liu, Emory University).

Nanoprobes Enable Measurement of T-Cell Binding Forces

A team of biochemical engineers has demonstrated that activation of immune system T-cells by foreign antigens has a physical component that is just as important to the process as immunochemical recognition. More...
02 Jun 2016
Image: Researchers have produced insulin-secreting cells from stem cells derived from the skin of patients with type I diabetes. The cells (blue), made from stem cells, can secrete insulin (green) in response to glucose (Photo courtesy of Millman Laboratory, Washington University School of Medicine).

Researchers Generate Stem Cell-derived Beta-cells from Patients with Diabetes

Diabetes researchers have succeeded in generating functional insulin-secreting beta cells from stem cells derived from patients with the type I form of the disease. More...
01 Jun 2016
Image: Cocoons of the silk moth Bombyx mori were used to isolate the silk fibroin used in the study (Photo courtesy of Wikimedia Commons).

Silk-Based Technique Stabilizes Fluid Samples for Diagnostics or Research

Drying blood or other biological fluid samples together with silk fibroin has been suggested as an alternative to refrigeration or drying on paper for transporting specimens from the field to the laboratory. More...
01 Jun 2016
Image: In some cancers, including chondroblastoma and a rare form of childhood sarcoma, a mutation in histone H3 reduces global levels of methylation (dark areas) in tumor cells but not in normal cells (arrowhead). This mutation arrests the cells in a proliferative state to promote tumor development (Photo courtesy of The Rockefeller University).

Histone Mutation Sufficient to Trigger Cancer Development

A missense mutation in a histone protein has been shown to be able to prompt the development of cancer cells without any change to the DNA of the cells that are involved. More...
01 Jun 2016
Image: Combining 2-DG with fenofibrate yields two forms of cancer cell death (Photo courtesy of the University of Miami School of Medicine).

Non-Toxic Drug Combination Induces Stress that Kills Cancer Cells

Growth of several different types of cancers was blocked by combined treatment with the sugar 2-Deoxy-D-glucose (2-DG) and the cholesterol-lowering drug fenofibrate. More...
31 May 2016
Image: A dark field photomicrograph showing the spirochete bacterium Borrelia burgdorferi, the pathogen responsible for causing Lyme disease (Photo courtesy of the CDC).

Statins May Help Block Transmission of Lyme Disease

A recent study found that treatment with cholesterol-lowering statins reduced the number of Borrelia burgdorferi bacteria in rodents, which helped to block transmission of Lyme disease. More...
31 May 2016
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BioResearch brings the latest research news on the genome, proteome, metabolome, on drug discovery, and therapeutics. Biotech researchers, lab administrators, technologists, drug manufacturers, and suppliers can find the latest research news and information related to their fields of endeavor here.
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