BioResearch
Development of Anti-Cancer Drugs May Overlook Compounds Useful for Humans
A large proportion of cancer research is done with mouse models; however a recent paper suggested that differences between the mouse and human genomes may lead to promising approaches to curing the disease in humans being overlooked. More...21 Dec 2016
![Image: Cells that express exon 6-truncated p53 protein exhibit structural features that reflect their reprogramming away from stability and toward proliferation and metastasis. This was apparent when comparing cells that do not express the truncated form of the protein (left column) with those that do (right column). The two images at the top are composites, with blue indicating DNA (i.e., cell nuclei); and green and red corresponding, respectively, with the proteins actin and e-cadherin. In the cells reprogrammed by truncated p53 proteins, actin fibers (middle image) show stress, while the signal from e-cadherin \"glue\" drops out altogether (bottom image). These cells are much more likely to break away from tissue and travel in the body (Photo courtesy of Sordella Laboratory, Cold Spring Harbor Laboratory).](https://globetechcdn.com/mobile_labmedica/images/stories/articles/article_images/2016-12-20/GMS-445.jpg "Image: Cells that express exon 6-truncated p53 protein exhibit structural features that reflect their reprogramming away from stability and toward proliferation and metastasis. This was apparent when comparing cells that do not express the truncated form of the protein (left column) with those that do (right column). The two images at the top are composites, with blue indicating DNA (i.e., cell nuclei); and green and red corresponding, respectively, with the proteins actin and e-cadherin. In the cells reprogrammed by truncated p53 proteins, actin fibers (middle image) show stress, while the signal from e-cadherin \\"glue\\" drops out altogether (bottom image). These cells are much more likely to break away from tissue and travel in the body (Photo courtesy of Sordella Laboratory, Cold Spring Harbor Laboratory).")
![Image: A fluorescent micrograph showing detection of Salmonella (red) in macrophages (green) and other immune cells in the ventricles of the brain of a mouse orally fed Salmonella. Salmonella-infected areas were associated with an increase of cells (blue nucleus) in the ventricles and meninges of the brain, a hallmark of bacterial meningitis (Photo courtesy of the [U.S.] National Institute of Allergy and Infectious Diseases).](https://globetechcdn.com/mobile_labmedica/images/stories/articles/article_images/2016-12-20/GMS-443.jpg "Image: A fluorescent micrograph showing detection of Salmonella (red) in macrophages (green) and other immune cells in the ventricles of the brain of a mouse orally fed Salmonella. Salmonella-infected areas were associated with an increase of cells (blue nucleus) in the ventricles and meninges of the brain, a hallmark of bacterial meningitis (Photo courtesy of the [U.S.] National Institute of Allergy and Infectious Diseases)."){kind=small}
Mouse Study Identifies Molecular Mechanism behind Bacterial Meningitis
A team of molecular microbiologists examined the ability of the bacterium Salmonella enterica serovar Typhimurium to infect the central nervous system and cause meningitis following the natural route of infection in mice. More...20 Dec 2016
Proteasome Inhibitor Treatment Repairs Effects of Ribosomal Damage in Multiple Myeloma
A recent paper suggested that severity of a type of multiple myeloma characterized by a deletion from the genome that caused dysfunction of ribosome function could be reduced by treatment with a proteasome inhibitor. More...20 Dec 2016
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Anemia Proteins Function Cooperatively with PTEN Tumor Suppressor
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Next-Generation Drugs Circumvent Adverse Immune Response
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Gene Therapy Prevents Cancer Cells from Surviving in Hypoxic Environment
Loss of Neuronal Enzyme Underlies Rare Childhood Epileptic Encephalopathy
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Antibody-Zika Virus Interaction Visualized by Cryo-Electron Microscopy
Two Classes of Fibroblasts Inhabit the Synovial Membrane in RA
HDL Increases Macrophage Immune Response
Faulty Protein Interaction Disrupts Neuromuscular Junctions and Triggers ALS
Study Explains How Protein Complex Mediates T-cell Development
Synthetic Hydrogel System for Growth of Intestinal Organoids
Anti-inflammatory Cytokine Prevents Development of Insulin Resistance in Model
Phosphorylation of Tau Protein Inhibits Amyloid-beta Toxicity in Alzheimer’s Model
Blocking the Acsl14 Enzyme Prevents Ferroptosis-Linked Cell Death
Lung and Tracheal Tissue Expected to Aid Respiratory Disease Research
BioResearch brings the latest research news on the genome, proteome, metabolome, on drug discovery, and therapeutics. Biotech researchers, lab administrators, technologists, drug manufacturers, and suppliers can find the latest research news and information related to their fields of endeavor here.