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BioResearch

Image: Neurons from Angelman syndrome (AS) patients lack expression of the UBE3A protein due to an epigenetic defect. The photomicrograph shows that a new method restored normal expression of the UBE3A protein in neurons derived from the cells of an AS patient by correcting the aberrant methylation pattern (Photo courtesy of the Salk Institute for Biological Studies).

Artificial Editing Technique Modifies Gene Activity

A team of molecular biologists has developed an artificial epigenetic editing technique that adds methyl groups to DNA and modifies specific gene activity in a hereditary manner. More...
16 May 2017
Image: Fluorescent imaging of a tumor section identifies different types of macrophages (green) and T-cells (blue) present in the microenvironment of renal cell carcinoma (Photo courtesy of Karina Silina, University of Zurich).

Mass Cytometry Profiles to Aid Drug Development

Cancer researchers used a novel mass cytometry technique to reveal potential biomarkers for detection of renal cell carcinoma and to identify targets for development of immunotherapeutic agents to treat this essentially incurable disease. More...
15 May 2017
Image: Three-dimensional (3D)-printed cartilage constructs growing in tissue culture (Photo courtesy of the University of Gothenburg).

Stem Cell and 3D Printing Generate Viable Tissue

A team of Swedish cell biologists combined three-dimensional (3D) bio-printing with advanced stem cell technology to create viable cultures of cartilage tissue that had cellular and mechanical properties similar to patients’ natural cartilage. More...
11 May 2017
Image: Using CRISPR technology, researchers rewired stem cells to produce an anti-inflammatory arthritis drug for when the cells encounter inflammation (Photo courtesy of Ella Marushchenko).

Modified Stem Cells Used to Correct Arthritis Inflammation

Researchers have used CRISPR/Cas9 genome editing technology to create mouse stem cells able to infiltrate the joints, form cartilage tissue, and correct the autoimmune defects that are responsible for arthritis. More...
10 May 2017
Image: An image generated by cancerous cells labeled with the new chemiluminescent probe (Photo courtesy of Dr. Doron Shabat, Tel Aviv University).

New Probes Promise Exceptional Live Cell Images

Development of a new generation of chemiluminescent molecules is expected to lead to synthesis of efficient chemiluminescent probes for microscopy that will be suitable for use under physiological conditions and should provide exceptional live cell images. More...
09 May 2017
Image: A Magnolia grandiflora seed cone, a primary source of honokiol (Photo courtesy of Wikimedia Commons).

Honokiol Stimulation Used to Prevent Hypertrophy

The ancient herbal therapy substance honokiol, which is derived from the bark, seed cones, and leaves of trees belonging to the genus Magnolia, has chemical properties that enable it to protect the heart from hypertrophy. More...
08 May 2017
Image: A confocal micrograph of mouse retina depicting optic fiber layer (Photo courtesy of the National Center for Microscopy and Imaging Research, University of California, San Diego).

Gene Editing Restores Vision in Mouse RP Models

The CRISPR/Cas9 gene-editing tool was used to reprogram defective optical rod photoreceptor cells and transform them into functioning cone photoreceptors, which restored impaired vision in two mouse models of retinitis pigmentosa. More...
04 May 2017
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BioResearch brings the latest research news on the genome, proteome, metabolome, on drug discovery, and therapeutics. Biotech researchers, lab administrators, technologists, drug manufacturers, and suppliers can find the latest research news and information related to their fields of endeavor here.
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