We use cookies to understand how you use our site and to improve your experience. This includes personalizing content and advertising. To learn more, click here. By continuing to use our site, you accept our use of cookies. Cookie Policy.

Mammoth Biosciences Presents AACC 2021 Disruptive Technology Award Finalist CRISPR-Based Detection Platform

By LabMedica International staff writers
Posted on 29 Sep 2021

Illustration

Mammoth Biosciences (San Francisco, CA, USA) presented its revolutionary CRISPR-based detection platform that is enabling limitless testing possibilities and was also one of the AACC 2021 Disruptive Technology award finalists.

Mammoth has catalyzed a new approach to molecular diagnostics, called DETECTR. Based on CRISPR, this programmable platform acts as a search engine for biology and is capable of finding and identifying any nucleic acid sequence in the genome. Using proprietary technology licensed exclusively from the University of California, Berkeley and developed internally, Mammoth is working on multiple form factors and test targets from infectious diseases to cancer. For example, DETECTR was configured in less than two weeks to detect SARS-CoV-2, demonstrating the platform’s ability to be quickly tailored to identify any DNA or RNA target. The resulting product, DETECTR BOOST, is a reagent kit that when combined with standard laboratory automation provides labs with unparalleled high throughput molecular testing.

Mammoth was also one of the AACC 2021 Disruptive Technology award finalists. AACC's Disruptive Technology Award Competition recognizes innovative testing and disruptive technology solutions that improve patient care through diagnostic performance or access to high quality testing. It provides an opportunity for early to mid-stage start-ups in the medical device, diagnostic, or digital health/health IT spaces to showcase their technology and present to a large audience and a panel of judges.

Related Links:
Mammoth Biosciences

Visit expo >

Platinum Member

Automated Coagulation Analyzer

Hemolumi H6

βeta-Hydroxybutyrate Reagent
β-Hydroxybutyrate LiquiColor®

Gold Member

Pre- Eclampsia Control

Acusera Pre-Eclampsia Control

New

Gold Member

Serum Indices Control

Acusera Serum Indices Control

ADLM

Latest AACC 2021 News

Channels

Clinical Chemistry

view channel

Image Credit: Shutterstock

Common Kidney Function Tests May Miss CKD in Cancer Patients

Chronic kidney disease (CKD) can complicate cancer care, as reduced kidney filtration may affect treatment eligibility and dosing. In oncology, kidney function assessment often relies on estimated glomerular... Read more

Image Credit: Adobe Stock

Point-of-Care Blood Biomarker Test Detects Brain Injury Missed by CT

Traumatic brain injury remains difficult to assess in emergency settings because some patients continue to have symptoms despite normal computed tomography findings. Approximately 2.8 million people in the U.... Read more

Daily Blood Testing May Help Guide Earlier Antibiotic Stopping in Sepsis

Sepsis is a life-threatening condition caused by the body’s overwhelming response to infection and accounts for thousands of deaths each year. In intensive care, concern about stopping treatment too early... Read more

Image: Blood proteins measured years before diagnosis may signal future prostate cancer risk, including aggressive disease.(Image Credit: iStock)

Blood Proteins Reveal Signals Linked to Prostate Cancer Risk Years Before Diagnosis

Prostate cancer is the most commonly diagnosed cancer in men worldwide. While many tumors grow slowly, aggressive forms can be life-threatening, underscoring the need for earlier risk identification.... Read more

Molecular Diagnostics

view channel

Updated Framework Guides Assessment of Actionable Cancer Biomarkers

Cancer care increasingly relies on molecular testing to guide targeted treatment selection. Broader use of tumor sequencing has expanded the volume and diversity of biomarker data available to oncologists,... Read more

Genomic Tissue Test Predicts Metastasis and Abiraterone Benefit in High-Risk Prostate Cancer

Prostate cancer is the most common cancer in men, affecting more than 1 million men worldwide in 2013. Its clinical course varies substantially between patients, complicating efforts to identify those... Read more

RNA Sequencing Assay Gains EU Certification for Solid Tumor Profiling

Genomic profiling of solid tumors supports clinical management by detecting gene rearrangements and specific splice variants. Combining RNA and DNA testing can identify more clinically actionable gene... Read more

Image: Spleen tissue from a mouse without PHF19 (left) and a mouse with normal PHF19 function (right). Dense clusters of immune cells sit within blood-rich regions in pink. Without PHF19, cells are altered in their differentiation process (Photo courtesy of Gianni Gamarra/Centro de Regulación Genómica)

Six-Gene Score Improves Prognosis Prediction in Acute Myeloid Leukemia

Acute myeloid leukemia (AML) is a blood cancer with outcomes that can vary widely from one patient to another. This variability complicates prognosis despite the laboratory information available from bone... Read more

Hematology

view channel

New Risk-Stratification Tool Predicts Relapse After Blinatumomab in Childhood ALL

Acute lymphoblastic leukemia in children and young people requires careful assessment of relapse risk, particularly as treatment approaches move beyond standard chemotherapy. Traditional relapse predictors... Read more

New Myelofibrosis Guidelines Recommend Expanded Genetic Testing at Diagnosis

Myelofibrosis is a rare, life-threatening blood cancer affecting up to six per 100,000 people. The disease causes scarring in the bone marrow, limiting the production of healthy blood cells and potentially... Read more

Handheld Point-of-Care Test Aims to Enable Rapid Coagulation Assessment in Trauma

Severe blood loss and inadequate tissue oxygenation are leading causes of preventable death after traumatic injury. Blood products are essential in trauma care, but cold-chain storage, short shelf life,... Read more

Image Credit: Adobe Stock

New Donor Genetic Marker May Help Predict Stem Cell Transplant Success

Donor selection for hematopoietic stem cell transplantation plays a major role in relapse risk and survival for patients with blood cancers and other blood disorders. Despite advances in genotyping, uncertainty... Read more

Immunology

view channel

Antibody Profiling Predicts Inflammatory Bowel Disease Years Before Diagnosis

Inflammatory bowel disease (IBD), which includes Crohn’s disease and ulcerative colitis, involves abnormal immune responses that cause persistent inflammation and damage in the digestive system.... Read more

Immune Profiling Initiative Aims to Improve Bone Marrow Analysis in Leukemia

Acute myeloid leukemia (AML) is an aggressive blood cancer in which assessing disease burden after therapy can help guide clinical evaluation. Patients with measurable residual disease (MRD) after treatment... Read more

Immune Profiling Identifies Early Maternal Autoantibodies Linked to Preterm Birth Risk

A typical pregnancy lasts about 40 weeks, but labor begins prematurely in roughly one in 10 pregnancies. Preterm birth is the leading cause of newborn death worldwide, yet its underlying causes and which... Read more

Image: Graphical Abstract (M. A. A. Kodydek, M. E. Reyna, A. Kothari, et al., “ IgE Sensitization Patterns of Mothers and Their Offspring in the First Five Years of Life The CHILD Study,” Allergy (2026): 1–11, https://doi.org/10.1111/all.70516)

Longitudinal Blood Testing Reveals Changes in Allergen Sensitization During Childhood

Food allergy is a major childhood health concern, and distinguishing persistent risk from transient sensitization can guide clinical decisions. Specific IgE antibodies may be detectable even when a child... Read more

Microbiology

view channel

Decentralized Laboratory Network Improves Detection of Viral Hemorrhagic Fevers in Guinea

Viral hemorrhagic fevers remain a major diagnostic challenge in West Africa because their early symptoms can resemble those of other febrile illnesses. The 2014–2016 Ebola epidemic underscored the need... Read more

Molecular Panel Gains WHO Emergency Use Listing to Support Ebola Outbreak Response

The ongoing Ebola Bundibugyo outbreak in the Democratic Republic of the Congo and neighboring countries has become one of the largest outbreaks of this Ebola virus species recorded to date.... Read more

Rapid Host-Response Test Aims to Predict Corticosteroid Benefit in Sepsis

Sepsis and severe infections are difficult to treat because patients with similar clinical presentations may have very different underlying immune responses. Corticosteroids are commonly used in severe... Read more

Oral and Lung Microbiome Changes Linked to Severe Long Covid Symptoms

Long Covid can involve persistent respiratory, cognitive, and gastrointestinal symptoms after acute infection, creating a difficult diagnostic and management challenge. Because COVID-19 initially affects... Read more

Pathology

view channel

Digital Pathology Test Stratifies Recurrence Risk in Early Breast Cancer

In hormone receptor-positive, human epidermal growth factor receptor 2 (HER2)-negative early breast cancer, accurate recurrence-risk assessment helps guide treatment decisions. However, individual risks... Read more

$Image: Ovarian cancer tissue image. (Photo courtesy of Heba Sailem/King\'s College London)$

AI Pathology Tool Predicts DNA Repair Deficiency in High-Grade Serous Ovarian Cancer

High-grade serous tubo-ovarian carcinoma is an aggressive cancer arising in the ovaries or fallopian tubes. Some tumors exhibit homologous recombination deficiency (HRD), a feature reflecting impaired DNA repair.... Read more

AI Tissue Analysis May Help Identify Missed Precancerous Colon Polyps

Colorectal cancer is diagnosed in an estimated 1.9 million people worldwide each year, often without symptoms in its early stages. Timely detection of precancerous lesions is therefore important, yet some... Read more

AI Pre-Screening Helps Identify Lung Cancer Cases for Additional Biomarker Testing

Tempus AI (Chicago, IL, USA) will present findings from a study evaluating an artificial intelligence (AI)-enabled pre-screening panel for advanced non-small cell lung cancer (NSCLC) at the ESMO Congress... Read more

Technology

view channel

Compact PCR Thermal Cycler Launches for Routine Molecular Laboratory Workflows

Molecular laboratories rely on nucleic acid analysis to detect molecular information accurately and reproducibly across a wide range of applications. Supporting these routine workflows, a newly launched... Read more

New AI-Powered System Aims to Streamline Laboratory and Manufacturing Workflows

Scientific laboratories supporting drug development, biotechnology, and materials research increasingly rely on coordinated digital workflows to move data, samples, and activities across teams.... Read more

Laser-Based Swab Analysis Shows Promise for Detecting Disease-Linked Odor Patterns

Disease-related changes in volatile organic compounds can alter body odor, producing measurable patterns in exhaled breath and bodily fluids. Current analytical methods can be complex, time-consuming,... Read more

Image: Antibody-coated microscopic beads are introduced into a tiny flow channel containing blood plasma. Laser irradiation enhances their interaction with CEACAM-5, a colorectal cancer biomarker, causing the beads to assemble and generate a detectable signal. (Image Credit: Figure reproduced from Iida et al., Nanoscale Horizons(2026), DOI: 10.1039/d6nh00017g. Licensed under CC BY-NC 4.0.)

Laser-Enhanced Assay Boosts Sensitivity for Colorectal Cancer Biomarker Detection

Colorectal cancer is the third most commonly diagnosed cancer and the second leading cause of cancer-related death worldwide. Early detection remains critical, but cancer biomarkers can produce only faint... Read more

Industry

view channel

Collaboration Brings Tumor-Informed MRD Monitoring to Breast Cancer Care in Abu Dhabi

For many patients, cancer treatment does not eliminate the risk of recurrence, which may occur months or years later and become harder to treat after spreading. Recurrence is often detected only after... Read more

Real Diagnostics Adds Saliva-Based Periodontal Testing With SimplyTest Deal

Real Diagnostics (Reisterstown, MD, USA) has acquired SimplyTest (Huntsville, AL, USA), a provider of saliva-based diagnostic tests for oral health. The acquisition adds the SimplyTest PERIO product to... Read more

Qiagen Agrees to Go Private Through EQT-Led Acquisition

QIAGEN N.V. (Venlo, the Netherlands) and EQT Private Equity (Stockholm, Sweden) have agreed to an all-cash public takeover offer for all outstanding QIAGEN shares at EUR 46.50 per share.... Read more

Hologic and Inpeco Partner to Advance Molecular Laboratory Automation in Europe

Hologic, Inc. (Marlborough, MA, USA) and Inpeco S.A. (Novazzano, Switzerland) have signed a co-marketing partnership in Europe for Inpeco’s recently launched FlexLab X automation solution and Hologic’s... Read more