Mammoth Biosciences Presents AACC 2021 Disruptive Technology Award Finalist CRISPR-Based Detection Platform

By LabMedica International staff writers
Posted on 29 Sep 2021

Illustration

Mammoth Biosciences (San Francisco, CA, USA) presented its revolutionary CRISPR-based detection platform that is enabling limitless testing possibilities and was also one of the AACC 2021 Disruptive Technology award finalists.

Mammoth has catalyzed a new approach to molecular diagnostics, called DETECTR. Based on CRISPR, this programmable platform acts as a search engine for biology and is capable of finding and identifying any nucleic acid sequence in the genome. Using proprietary technology licensed exclusively from the University of California, Berkeley and developed internally, Mammoth is working on multiple form factors and test targets from infectious diseases to cancer. For example, DETECTR was configured in less than two weeks to detect SARS-CoV-2, demonstrating the platform’s ability to be quickly tailored to identify any DNA or RNA target. The resulting product, DETECTR BOOST, is a reagent kit that when combined with standard laboratory automation provides labs with unparalleled high throughput molecular testing.

Mammoth was also one of the AACC 2021 Disruptive Technology award finalists. AACC's Disruptive Technology Award Competition recognizes innovative testing and disruptive technology solutions that improve patient care through diagnostic performance or access to high quality testing. It provides an opportunity for early to mid-stage start-ups in the medical device, diagnostic, or digital health/health IT spaces to showcase their technology and present to a large audience and a panel of judges.

Related Links:
Mammoth Biosciences

Visit expo >

New

Gold Member

Nucleic Acid Extractor System

NEOS-96 XT

POC Helicobacter Pylori Test Kit
Hepy Urease Test

New

HPV Test

Allplex HPV28 Detection

New

Automated Clinical Chemistry Analyzer

Envoy 500+

ADLM

Latest AACC 2021 News

Channels

Clinical Chemistry

view channel

Blood Metabolite Test Detects Early Cognitive Decline

Timely identification of individuals at risk of dementia remains difficult because symptoms commonly appear only after significant neurodegeneration. Accessible screening tools that flag subtle cognitive... Read more

AI-Based Blood Test Diagnose Multiple Brain Disorders from Blood Sample

Diagnosing the cause of age-related cognitive symptoms remains challenging because clinical presentations of neurodegenerative diseases often overlap, and multiple pathologies can co-occur... Read more

New CLIA Status Brings Mass Spectrometry Steroid Testing to Routine Labs

Steroid hormone measurement is a core application of clinical mass spectrometry, which is widely regarded as a diagnostic gold standard. Access to these high-specificity methods has often been constrained... Read more

Image: New findings show that combining blood markers ehances both detection and staging of Alzheimer’s Disease (photo courtesy of Adobe Stock)

Study Shows Dual Biomarkers Improve Accuracy of Alzheimer’s Detection

Alzheimer’s disease develops slowly, and biological changes can appear in blood many years before symptoms. While plasma assays for phosphorylated tau offer earlier detection, discerning whether these... Read more

Molecular Diagnostics

view channel

ctDNA MRD Test Identifies Breast Cancer Patients Who May Avoid Surgery

Selecting surgery versus non-surgical management in early-stage breast cancer can be challenging for older patients, who often balance disease control with comorbidities and quality-of-life considerations.... Read more

WGS MCED Assay Demonstrates Rising Sensitivity and High Specificity

Early detection of cancer remains difficult across many tumor types, and current single‑cancer screening modalities leave significant gaps. Blood‑based, multi‑cancer assays aim to detect tumor signals... Read more

RNA Profiling Uncovers Therapeutic Targets in Solid Tumors

Many patients with advanced solid tumors exhaust broad DNA panel testing yet still lack biomarkers that match guideline-recommended therapies, limiting access to targeted options. Expanding molecular profiling... Read more

Whole Genome Sequencing in Routine Care Expands Rare Disease Detection

Rare diseases often involve prolonged diagnostic journeys that delay clinical decision-making and complicate family planning. As phenotypes become more heterogeneous, sequencing-based methods are increasingly... Read more

Hematology

view channel

$Image: Hemex Health’s Gazelle platform is designed to rapidly separate and detect hemoglobin fractions and variants using miniaturized electrophoresis technology (photo courtesy of Hemex Health)$

Rapid Cartridge-Based Test Aims to Expand Access to Hemoglobin Disorder Diagnosis

Sickle cell disease and beta thalassemia are hemoglobin disorders that often require referral to specialized laboratories for definitive diagnosis, delaying results for patients and clinicians.... Read more

New Guidelines Aim to Improve AL Amyloidosis Diagnosis

Light chain (AL) amyloidosis is a rare, life-threatening bone marrow disorder in which abnormal amyloid proteins accumulate in organs. Approximately 3,260 people in the United States are diagnosed... Read more

Image: The new device can fit in the palm and is capable of measuring the quality of red blood cells (Photo courtesy of Xiaoyun Ding)

Fast and Easy Test Could Revolutionize Blood Transfusions

Blood transfusions are a cornerstone of modern medicine, yet red blood cells can deteriorate quietly while sitting in cold storage for weeks. Although blood units have a fixed expiration date, cells from... Read more

Automated Hemostasis System Helps Labs of All Sizes Optimize Workflow

High-volume hemostasis sections must sustain rapid turnaround while managing reruns and reflex testing. Manual tube handling and preanalytical checks can strain staff time and increase opportunities for error.... Read more

Immunology

view channel

Image: Mycobacterium tuberculosis bacteria seen with a scanning electron microscope (Credit: CDC PHIL)

Antibody Blood Test Identifies Active TB and Distinguishes Latent Infection

Active tuberculosis (TB) remains a leading cause of death and illness worldwide, yet distinguishing contagious disease from latent infection continues to challenge clinicians. Standard screening tools... Read more

FDA Approval Expands Use of PD-L1 Companion Diagnostic in Esophageal and GEJ Carcinomas

Esophageal and gastroesophageal junction carcinomas (GEJ) have a poor prognosis, with approximately 16,250 deaths in the United States in 2025 and a five-year relative survival of 21.9%.... Read more

Image: The findings indicate common blood tests can provide insight to tumor activity before treatment begins (photo courtesy of Adobe Stock)

Study Identifies Inflammatory Pathway Driving Immunotherapy Resistance in Bladder Cancer

Bladder cancer remains a prevalent malignancy with variable responses to immune checkpoint inhibitors. Clinicians often observe elevated C-reactive protein and interleukin-6 in affected patients, yet the... Read more

Image: Overview of the microfluidic assay for cancer-associated leukocyte adhesion profiling (Photo courtesy of Brian Choi, Seyong Kwon, Min Seok Lee, et al.,)

Microfluidic Chip Detects Cancer Recurrence from Immune Response Signals

Early identification of treatment response and relapse remains a major challenge in solid tumors, where minimal residual disease is difficult to detect with routine imaging and blood tests.... Read more

Microbiology

view channel

New Bacterial Target Identified for Early Detection of Noma

Noma is a rapidly progressing orofacial infection that begins as gingivitis and can destroy oral and facial tissues, primarily affecting young children living in extreme poverty. Without treatment, it... Read more

Genomic Analysis Links Emerging Streptococcal Strains to Specific Infections

Streptococcus dysgalactiae subspecies equisimilis (SDSE) infections are increasing worldwide and include variants that may lead to severe disease. Researchers now report that whole-genome sequencing of... Read more

Image: The direct-from-urine rapid method can identify an effective antibiotic in an average of 5.85 hours (photo courtesy of Shutterstock)

Rapid Urine Test Speeds Antibiotic Selection for UTIs

Urinary tract infections are a common reason for antibiotic prescribing and have led to more than 800,000 hospital admissions across England in the past five years, according to National Health Service data.... Read more

Image: The guidance recommends easy‑to‑collect tongue swab samples and a cost‑saving sputum pooling strategy for TB and rifampicin‑resistant TB. (photo courtesy of WHO / Enric Catala Contreras)

WHO Endorses Rapid Point-of-Care Testing to Improve TB Detection

Tuberculosis (TB) remains a leading infectious killer, with more than 3,300 deaths and 29,000 new illnesses every day. Diagnostic delays and dependence on centralized laboratory networks continue to impede... Read more

Pathology

view channel

AI Tool Predicts Patient-Specific Chemotherapy Benefit in Breast Cancer

Selecting adjuvant chemotherapy for early-stage breast cancer is typically guided by recurrence risk and population-level averages rather than patient-specific benefit. However, existing clinicopathologic... Read more

Image: Study cohorts, deep learning system architecture, and performance evaluation on TAILORx-Test (Shamai G, Cohen S, Binenbaum Y et al., Lancet Oncology, 2026; . DOI: 10.1016/s1470-2045(25)00727-2)

AI-Based Pathology Model Guides Chemotherapy Decisions in Breast Cancer

Selecting adjuvant chemotherapy for early-stage breast cancer remains a difficult decision because only a subset benefits and many undergo toxicity without gain. Genomic assays can help but are costly,... Read more

Biopsy-Based Gene Test Predicts Recurrence Risk in Lung Adenocarcinoma

Lung cancer is the leading cause of cancer death, killing more people in the United States than breast, prostate, and colon cancers combined. In lung adenocarcinoma (LUAD), tumors that invade nearby blood... Read more

AI-Powered Tool to Transform Dermatopathology Workflow

Skin cancer accounts for the largest number of cancer diagnoses in the United States, placing sustained pressure on pathology services. Diagnostic interpretation can be variable for challenging melanocytic... Read more

Technology

view channel

Image: Graphical Abstract (Huiqian Hu et al., Med 7(3): 100966 (2026). DOI: 10.1016/j.medj.2025.100966)

New AI Tool Enables Rapid Treatment Selection in Pediatric Leukemia

Children with T-cell acute lymphoblastic leukemia face an aggressive disease that remains difficult to treat. Although remission rates have improved, many survivors experience long-term effects from intensive... Read more

Image: The new MultiQ-IT prototype can cool, trap, filter, and redirect over a billion ions simultaneously, dramatically improving dynamic range and signal-to-noise (Photo courtesy of Lori Chertoff/The Rockefeller University)

Breakthrough Mass Spectrometry Design Could Enable Ultra-Low Abundance Detection

Mass spectrometry is central to identifying and quantifying molecules in complex biological samples, but conventional instruments typically analyze ions sequentially, which can limit detection of rare species.... Read more

Image: Schematic illustration of the MetaRing platform for detecting paclitaxel treatment sensitivity in breast cancer (Photo courtesy of HUANG Guangyao)

Rapid Biosensor Detects Drug Sensitivity in Breast Tumors

Chemotherapy selection for breast cancer is challenged by heterogeneous tumor responses. Conventional chemosensitivity assays can be slow, require large sample volumes, and struggle with complex biological... Read more

Online Tool Supports Family Screening for Inherited Cancer Risk

Genetic test results in oncology often have implications for relatives who may share inherited cancer risk. Many health systems lack structured processes to help patients alert family members, limiting... Read more

Industry

view channel

Takara Bio USA and Hamilton Partner Partner to Automate NGS Library Preparation

Takara Bio USA, Inc. (San Jose, CA, USA), a wholly owned subsidiary of Takara Bio Inc., and Hamilton Company (Reno, NV, USA) announced a development and co-marketing agreement to deliver integrated, automated... Read more

Lunit and CellCarta Collaborate to Expand AI Pathology in CDx Development

Lunit (Seoul, South Korea), a leading provider of AI for cancer diagnostics and precision oncology, and CellCarta (Montreal, QC, Canada), a global contract research organization (CRO) laboratory serving... Read more

Integrated DNA Technologies Expands into Clinical Diagnostics

Integrated DNA Technologies (IDT; Coralville, Iowa, USA) has announced the launch of Archer FUSIONPlex-HT Dx and VARIANTPlex-HT Dx. This launch marks the company’s first in vitro diagnostic (IVD) offerings... Read more

Co-Diagnostics Agreement Expands Commercial and Distribution Reach in South Asia

Co-Diagnostics (Co-Dx; Salt Lake City, UT, USA) has signed an agreement for CoSara Diagnostics Pvt. Ltd., its Indian joint venture with Ambalal Sarabhai Enterprises Limited (Ahmedabad, India), to extend... Read more