We use cookies to understand how you use our site and to improve your experience. This includes personalizing content and advertising. To learn more, click here. By continuing to use our site, you accept our use of cookies. Cookie Policy.

Mammoth Biosciences Presents AACC 2021 Disruptive Technology Award Finalist CRISPR-Based Detection Platform

By LabMedica International staff writers
Posted on 29 Sep 2021

Illustration

Mammoth Biosciences (San Francisco, CA, USA) presented its revolutionary CRISPR-based detection platform that is enabling limitless testing possibilities and was also one of the AACC 2021 Disruptive Technology award finalists.

Mammoth has catalyzed a new approach to molecular diagnostics, called DETECTR. Based on CRISPR, this programmable platform acts as a search engine for biology and is capable of finding and identifying any nucleic acid sequence in the genome. Using proprietary technology licensed exclusively from the University of California, Berkeley and developed internally, Mammoth is working on multiple form factors and test targets from infectious diseases to cancer. For example, DETECTR was configured in less than two weeks to detect SARS-CoV-2, demonstrating the platform’s ability to be quickly tailored to identify any DNA or RNA target. The resulting product, DETECTR BOOST, is a reagent kit that when combined with standard laboratory automation provides labs with unparalleled high throughput molecular testing.

Mammoth was also one of the AACC 2021 Disruptive Technology award finalists. AACC's Disruptive Technology Award Competition recognizes innovative testing and disruptive technology solutions that improve patient care through diagnostic performance or access to high quality testing. It provides an opportunity for early to mid-stage start-ups in the medical device, diagnostic, or digital health/health IT spaces to showcase their technology and present to a large audience and a panel of judges.

Related Links:
Mammoth Biosciences

Visit expo >

Platinum Member

Automated Coagulation Analyzer

Hemolumi H6

Gold Member

Quantitative POC Immunoassay Analyzer

EASY READER+

Electrolyte Analyzer

BKE-B

All-in-One Molecular System

AIO M160

ADLM

Latest AACC 2021 News

Channels

Clinical Chemistry

view channel

International Consensus Guidance Outlines General Population Screening for Early-Stage Type 1 Diabetes

Type 1 diabetes (T1D) is an autoimmune disease that can develop in childhood or adulthood and affects an estimated 9.5 million people worldwide. Its complications range from acute diabetic ketoacidosis... Read more

Algorithm Uses Blood Biomarkers to Improve Alzheimer’s Trial Screening

Alzheimer’s disease is a progressive neurodegenerative disorder that causes memory loss and functional decline. Screening cognitively healthy adults for prevention trials is slow and costly because many... Read more

Electrical Fingerprint of Extracellular Vesicles Could Detect Pancreatic Cancer

Pancreatic cancer is often diagnosed only after it has spread, contributing to a five-year survival rate of 13%. Standard blood-based analyses can struggle to distinguish tumor signals from the background... Read more

Image Credit: 123RF

Blood Biomarker May Track Bone Metastases in Medullary Thyroid Cancer

Medullary thyroid cancer (MTC) is a rare malignancy that often progresses silently, frequently going undetected until it reaches advanced stages. By the time it spreads to bone, it can produce unusual... Read more

Molecular Diagnostics

view channel

Image: Researchers found that combining two Alzheimer’s tests—a p-tau217 blood test and APOE genotyping—can predict symptom onset in people who are not yet experiencing symptoms (Image Credit: Adobe Stock)

Combined Blood and Genetic Tests Estimate Timing of Alzheimer’s Symptom Onset

Predicting when Alzheimer’s disease will manifest remains a major clinical challenge, particularly before cognitive decline is evident. Blood biomarkers and genetic risk markers can flag elevated risk,... Read more

Image: Blood protein levels can reveal whether genetic variants have biological effects, potentially offering a more scalable, noninvasive way to obtain additional patient information (Image Credit: 123RF)

Blood Protein Analysis Helps Interpret Uncertain Rare Disease Variants

Many patients with suspected rare genetic conditions remain undiagnosed even after genome or exome sequencing, leaving clinicians with limited evidence to interpret uncertain variants. Variants of uncertain... Read more

40-Gene Test Validated for High-Risk Squamous Cell Carcinoma

High-risk cutaneous squamous cell carcinoma (SCC) requires accurate stratification to align surveillance and adjuvant therapy with each patient’s risk. Clinicopathologic staging alone may not precisely... Read more

Image: New findings identify common genetic variants are associated with faster motor decline in Parkinson’s disease (Image Credit: 123RF)

Common Genetic Marker Predicts Faster Motor Decline in Parkinson’s Disease

Parkinson’s disease is a progressive neurodegenerative disorder, but rates of motor decline vary widely among patients, complicating prognosis and clinical trial design. Clinicians have few scalable tools... Read more

Hematology

view channel

Hidden Molecular Mechanism Behind HIT Blood-Clotting Disorder Revealed

Immune-mediated thrombosis following heparin therapy can be sudden and severe, creating urgent diagnostic challenges. In heparin-induced thrombocytopenia (HIT), antibodies against platelet factor 4 (PF4)... Read more

Image: New findings indicate that people with borderline anemia—hemoglobin just above WHO anemia thresholds—face a higher mortality risk than those with higher hemoglobin levels within the normal range (Image Credit: 123RF)

Borderline Anemia May Carry Higher Risk Than Current Thresholds Suggest

Hemoglobin concentration is among the most frequently ordered blood tests in primary and hospital care. In older adults, both high and low values have been linked to adverse outcomes, including cognitive... Read more

Biomarker-Guided Framework Aims to Guide Mantle Cell Lymphoma Therapy

Mantle cell lymphoma can follow widely variable courses, from indolent disease to rapidly progressive cancer, complicating initial treatment selection. Many therapeutic decisions still rely on patient... Read more

New Genetic Findings Reveal Cause of Bone Marrow Failure Syndrome

Inherited bone marrow failure syndromes (IBMFS) impair the bone marrow’s ability to produce sufficient healthy blood cells and are associated with an increased risk of early-onset myelodysplastic syndromes (MDS).... Read more

Immunology

view channel

Image Credit: Adobe Stock

New Cellular Map May Help Predict Crohn’s Disease Course in Children

Crohn’s disease in children is a common and debilitating form of inflammatory bowel disease, marked by chronic intestinal inflammation and limited pediatric-specific treatments. Clinicians must decide... Read more

Image Credit: Adobe Stock

Temporal Immune Profiling Reveals How Sepsis States Change Over Time

Sepsis is a life-threatening condition in which the immune response to infection becomes dysregulated, leading to rapid organ failure and death. Although antimicrobials and organ support remain standard... Read more

Study Identifies Immune Cells That Drive Harmful Autoantibody Responses in COVID-19

Autoantibodies that mistakenly attack the body’s own tissues have been linked to severe COVID-19, Long COVID, and increased risk of autoimmune disease. However, the origins of these autoantibodies during... Read more

Gut “Memory” May Explain Why IBD Flares Return

Inflammatory bowel diseases (IBD), including Crohn’s disease and ulcerative colitis, are characterized by recurring flare-ups that damage the intestinal mucosa and remain difficult to predict.... Read more

Microbiology

view channel

Diagnostic Stewardship Guide Targets Testing Overuse and Hospital Cost Pressures

Hospitals face persistent pressure to improve diagnostic accuracy while reducing unnecessary testing and costs. Misordered or overused assays can complicate infection metrics, trigger penalties, and strain... Read more

Research Strengthens Bundibugyo Virus Outbreak Readiness with Faster Diagnostics

Bundibugyo virus (BDBV), a species of ebolavirus, causes severe hemorrhagic disease and can be difficult to diagnose rapidly during outbreaks. Recent regulatory changes have further complicated swift deployment... Read more

Image Credit: Adobe Stock

Gut Microbiome Classifier Improves Colorectal Cancer Risk Stratification

Colorectal cancer remains a leading cause of cancer mortality, and current noninvasive screening methods still miss many precancerous lesions. Clinicians therefore need tools that improve risk stratification... Read more

Image: The “broth” used to monitor red blood cell depletion in whole blood spiked with one colony-forming-unit of E. coli bacteria, each incubated at different orbital shaking speeds—left to right: 0 RPM, 65 RPM, 120 RPM and 200 RPM—after four hours of incubation. This culturing raises a bacteria-rich, plasma-like layer of bacteria to the top of the vials, while clusters of stuck blood cells known as a Rouleaux formation sink to the bottom. (Image Credit: Pak Kin Wong)

New Diagnostic Workflow Identifies Bloodstream Pathogens and Antibiotic Response in Hours

Sepsis is a life-threatening complication of infection that affects more than 1.5 million patients annually in the United States and contributes to roughly one in three in-hospital deaths.... Read more

Pathology

view channel

Image: The workflow analyzes slides already generated during routine care, providing added prognostic information without requiring another tissue test (Image Credit: Shutterstock)

AI Spatial Analysis of Routine Slides Helps Predict Pancreatic Cancer Recurrence

Predicting which patients with pancreatic cancer will recur after treatment and surgery remains challenging. Pathology evaluation typically measures residual tumor burden, but recent work found that tumor... Read more

Hybrid Computational Imaging Method Improves Digital Pathology Resolution

Digital pathology depends on high-resolution whole-slide imaging to capture diagnostically relevant cellular and tissue features, yet conventional methods often force trade-offs between speed, cost, and detail.... Read more

FDA Clearance Expands Digital Pathology Options for Clinical Laboratories

Hamamatsu Photonics K.K. (Hamamatsu, Japan) announced it received 510(k) clearance from the U.S. Food and Drug Administration (FDA) for the NanoZoomer S20MD and NanoZoomer S540MD slide scanner systems.... Read more

Label-Free Imaging Reveals Hidden Immune Activity in Blood Samples

Peripheral blood mononuclear cells (PBMCs) are widely used to monitor infection, autoimmunity, cancer, and treatment response, yet most assays depend on fluorescent labels that can perturb cells and provide... Read more

Technology

view channel

Multimodal AI Framework Aims to Guide Cancer Immunotherapy Decisions

Cancer immunotherapy has reshaped oncology, but heterogeneous responses and immune-related toxicities continue to complicate routine decision-making. Standard biomarkers, including programmed death-ligand... Read more

New Multipurpose Centrifuge Combines High Capacity with Sustainable Cooling

Laboratories often need centrifugation that accommodates multiple vessel formats while maintaining controlled temperatures to protect sensitive samples. Intuitive controls and repeatable operation can... Read more

Bacterial Vesicle Expression System Streamlines Production of Cancer Diagnostic Proteins

Recombinant proteins are central to many cancer diagnostics and therapies, but numerous targets remain difficult and costly to produce because they are unstable, toxic to microbial hosts, or require precise folding.... Read more

Autonomous Robotic System Receives FDA Authorization for Blood Collection

Venipuncture is central to many diagnostic pathways, but routine blood collection can be affected by staffing constraints and procedural variability that influence consistency and patient experience.... Read more

Industry

view channel

Blood-Based Neurology Biomarker Assays Authorized for Use in Brazil

H.U. Group Holdings Inc. (Tokyo, Japan) and its wholly owned subsidiary Fujirebio announced that the Brazilian Health Regulatory Agency (ANVISA) has authorized the Lumipulse G NfL Blood and Lumipulse G... Read more

Image Credit: Adobe Stock

Sepsis Diagnostics Market Growth Fueled by Faster Pathogen Detection Needs

Sepsis diagnostics support early detection of bloodstream infections and sepsis by helping clinicians identify pathogens, assess disease severity, and guide antimicrobial therapy in emergency, ICU, inpatient,... Read more

Project Advances Single-Cell Diagnostic Test for Triple-Negative Breast Cancer

Triple-negative breast cancer (TNBC) accounts for 15% to 20% of breast cancers and is associated with high relapse rates, rapid progression, and limited treatment options. Clinicians still lack reliable... Read more

Sysmex and Cytek Collaboration Expands Access to Advanced Clinical Flow Cytometry

Sysmex Europe SE (Hamburg, Germany) and Cytek Biosciences (Fremont, CA, USA) are partnering across more than a dozen European countries to expand access to advanced clinical flow cytometry.... Read more