We use cookies to understand how you use our site and to improve your experience. This includes personalizing content and advertising. To learn more, click here. By continuing to use our site, you accept our use of cookies. Cookie Policy.

Mammoth Biosciences Presents AACC 2021 Disruptive Technology Award Finalist CRISPR-Based Detection Platform

By LabMedica International staff writers
Posted on 29 Sep 2021

Illustration

Mammoth Biosciences (San Francisco, CA, USA) presented its revolutionary CRISPR-based detection platform that is enabling limitless testing possibilities and was also one of the AACC 2021 Disruptive Technology award finalists.

Mammoth has catalyzed a new approach to molecular diagnostics, called DETECTR. Based on CRISPR, this programmable platform acts as a search engine for biology and is capable of finding and identifying any nucleic acid sequence in the genome. Using proprietary technology licensed exclusively from the University of California, Berkeley and developed internally, Mammoth is working on multiple form factors and test targets from infectious diseases to cancer. For example, DETECTR was configured in less than two weeks to detect SARS-CoV-2, demonstrating the platform’s ability to be quickly tailored to identify any DNA or RNA target. The resulting product, DETECTR BOOST, is a reagent kit that when combined with standard laboratory automation provides labs with unparalleled high throughput molecular testing.

Mammoth was also one of the AACC 2021 Disruptive Technology award finalists. AACC's Disruptive Technology Award Competition recognizes innovative testing and disruptive technology solutions that improve patient care through diagnostic performance or access to high quality testing. It provides an opportunity for early to mid-stage start-ups in the medical device, diagnostic, or digital health/health IT spaces to showcase their technology and present to a large audience and a panel of judges.

Related Links:
Mammoth Biosciences

Visit expo >

New

Gold Member

Automatic Chemiluminescence Immunoassay Analyzer

Shine i2000

Collection and Transport System
PurSafe Plus®

Hemodynamic System Monitor

OptoMonitor

6 Part Hematology Analyzer with RET + IPF

Mispa HX 88

ADLM

Latest AACC 2021 News

Channels

Clinical Chemistry

view channel

Image: Schematic diagram of esophageal cancer cell identification research process (Photo courtesy of GE Dianlong)

VOCs Show Promise for Early Multi-Cancer Detection

Early cancer detection is critical to improving survival rates, but most current screening methods focus on individual cancer types and often involve invasive procedures. This makes it difficult to identify... Read more

Image: Portable Raman spectroscopy could help detect kidney disease at POC (Photo courtesy of Shutterstock)

Portable Raman Spectroscopy Offers Cost-Effective Kidney Disease Diagnosis at POC

Kidney disease is typically diagnosed through blood or urine tests, often when patients present with symptoms such as blood in urine, shortness of breath, or weight loss. While these tests are common,... Read more

Image: Mesoporous gold nanoparticles have unique biosensing capabilities (Photo courtesy of The University of Queensland)

Gold Nanoparticles to Improve Accuracy of Ovarian Cancer Diagnosis

Ovarian cancer is considered one of the deadliest cancers, in part because it rarely shows clear symptoms in its early stages, and diagnosis is often complex. Current approaches make it difficult to accurately... Read more

Simultaneous Cell Isolation Technology Improves Cancer Diagnostic Accuracy

Accurate cancer diagnosis remains a challenge, as liquid biopsy techniques often fail to capture the complexity of tumor biology. Traditional systems for isolating circulating tumor cells (CTCs) vary in... Read more

Molecular Diagnostics

view channel

Multi-Cancer Early Detection Blood Test Increases Cancer Detection

Cancer is the second leading cause of death worldwide as most deadly cancers are found too late. Approximately 70% of cancer deaths come from cancers that do not have standard-of-care screening and are... Read more

Image: Schematic of microfluidic cell adhesion assay (Moghadam et al., Microsyst Nanoeng 11, 135 (2025). DOI: 10.1038/s41378-024-00862-7)

Portable Label-Free Device Tracks Alzheimer's Disease in Real Time

Alzheimer’s disease is marked by the accumulation of toxic protein fragments in the brain that damage nerve cells and impair memory. Detecting and tracking these early changes remains a major challenge,... Read more

Liquid Biopsy Test Enables Early Detection of ICI-Related Myocarditis

Cancer treatments have advanced significantly in recent years, but they can still trigger severe and sometimes fatal side effects. Immune checkpoint inhibitors (ICIs), which have transformed cancer therapy,... Read more

Image: A researcher demonstrates a portable POC diagnostic device for detecting asymptomatic malaria cases (Photo courtesy of Imperial College London)

Rapid POC Diagnostic Test Detects Asymptomatic Malaria Cases

Malaria is one of the leading causes of preventable deaths worldwide, with around 95% of all deaths occurring in Africa. Asymptomatic infections are a major driver of ongoing transmission because individuals... Read more

Hematology

view channel

Viscoelastic Testing Could Improve Treatment of Maternal Hemorrhage

Postpartum hemorrhage, severe bleeding after childbirth, remains one of the leading causes of maternal mortality worldwide, yet many of these deaths are preventable. Standard care can be hindered by delays... Read more

Image: New research points to protecting blood during radiation therapy (Photo courtesy of 123RF)

Pioneering Model Measures Radiation Exposure in Blood for Precise Cancer Treatments

Scientists have long focused on protecting organs near tumors during radiotherapy, but blood — a vital, circulating tissue — has largely been excluded from dose calculations. Each blood cell passing through... Read more

Image: Platelets sequester cfDNA during circulation (Murphy L. et al., Science, 2025; DOI: 10.1126/science.adp3971)

Platelets Could Improve Early and Minimally Invasive Detection of Cancer

Platelets are widely recognized for their role in blood clotting and scab formation, but they also play a crucial role in immune defense by detecting pathogens and recruiting immune cells.... Read more

Image: The microfluidic device for passive separation of platelet-rich plasma from whole blood (Photo courtesy of University of the Basque Country)

Portable and Disposable Device Obtains Platelet-Rich Plasma Without Complex Equipment

Platelet-rich plasma (PRP) plays a crucial role in regenerative medicine due to its ability to accelerate healing and repair tissue. However, obtaining PRP traditionally requires expensive centrifugation... Read more

Immunology

view channel

Molecular Microscope Diagnostic System Assesses Lung Transplant Rejection

Lung transplant recipients face a significant risk of rejection and often require routine biopsies to monitor graft health, yet assessing the same biopsy sample can be highly inconsistent among pathologists.... Read more

Blood Test Tracks Treatment Resistance in High-Grade Serous Ovarian Cancer

High-grade serous ovarian cancer (HGSOC) is often diagnosed at an advanced stage because it spreads microscopically throughout the abdomen, and although initial surgery and chemotherapy can work, most... Read more

Image: The tool enables scientists to track real-time fluctuations in T cell function with unprecedented speed and precision (Photo courtesy of Shutterstock)

Luminescent Probe Measures Immune Cell Activity in Real Time

The human immune system plays a vital role in defending against disease, but its activity must be precisely monitored to ensure effective treatment in cancer therapy, autoimmune disorders, and organ transplants.... Read more

Blood-Based Immune Cell Signatures Could Guide Treatment Decisions for Critically Ill Patients

When a patient enters the emergency department in critical condition, clinicians must rapidly decide whether the patient has an infection, whether it is bacterial or viral, and whether immediate treatment... Read more

Microbiology

view channel

Image: Sugar fingerprints open new possibilities for faster and more reliable diagnosis of fungal infections (Photo courtesy of 123RF)

Fast Noninvasive Bedside Test Uses Sugar Fingerprint to Detect Fungal Infections

Candida bloodstream infections are a growing global health threat, causing an estimated 6 million cases and 3.8 million deaths annually. Hospitals are particularly vulnerable, as weakened patients after... Read more

Image: A clinical test and handheld device could quickly classify sepsis patients into two groups (Photo courtesy of Sara Moser/WashU Medicine)

Rapid Sepsis Diagnostic Device to Enable Personalized Critical Care for ICU Patients

Sepsis is a life-threatening condition that occurs when the body’s response to infection spirals out of control, damaging organs and leading to critical illness. Patients often arrive at intensive care... Read more

Image: The CD Chip (top) and The CD² Chip (bottom) (Photo courtesy of YANG Xiao)

Microfluidic Platform Assesses Neutrophil Function in Sepsis Patients

Sepsis arises from infection and immune dysregulation, with neutrophils playing a central role in its progression. However, current clinical tools are unable to both isolate these cells and assess their... Read more

New Diagnostic Method Confirms Sepsis Infections Earlier

Sepsis remains one of the most dangerous medical emergencies, often progressing rapidly and becoming fatal without timely intervention. Each hour of delayed treatment in septic shock reduces patient survival... Read more

Pathology

view channel

Image: AI can increase access to life-saving cervical cancer diagnostics for women (Photo courtesy of Shutterstock)

AI Improves Cervical Cancer Screening in Low-Resource Settings

Access to cervical cancer screening in low- and middle-income countries remains limited, leaving many women without early detection for this life-threatening disease. The lack of access to laboratories,... Read more

Image: A UMAP graphical depiction of 45,963 cancer cells from patients whose chronic lymphocytic leukemia has transformed into a more aggressive type (Photo courtesy of the Nam lab)

New Multi-Omics Tool Illuminates Cancer Progression

Tracking how cancers evolve into more aggressive and therapy-resistant forms has long been a challenge for researchers. Many current tools can only capture limited genetic information from tumor samples,... Read more

New Technique Detects Genetic Mutations in Brain Tumors During Surgery within 25 Minutes

Determining the genetic profile of brain tumors during surgery is crucial for improving patient outcomes, but conventional analysis methods can take up to two days, delaying critical decisions.... Read more

New Imaging Tech to Improve Diagnosis and Treatment of Skin Cancers

Skin cancer is the most common malignancy worldwide, and accurately assessing tumor invasion or treatment response remains a major clinical challenge. Current imaging methods, such as confocal microscopy... Read more

Technology

view channel

Image: The acoustofluidic device is designed for sample preparation and detection of small extracellular vesicles (Photo courtesy of Tony Jun Huang/Duke University)

Acoustofluidic Device to Transform Point-Of-Care sEV-Based Diagnostics

Rapid and sensitive detection of small extracellular vesicles (sEVs)—key biomarkers in cancer and organ health monitoring—remains challenging due to the need for multiple preprocessing steps and bulky... Read more

AI Algorithm Assesses Progressive Decline in Kidney Function

Chronic kidney disease (CKD) affects more than 700 million people worldwide and remains a major global health challenge. The condition often progresses silently, and many patients remain undiagnosed until... Read more

Image: The technology enables infected individuals to detect an infection within minutes, without requiring a laboratory, electricity, or medical personnel (Raschig, M. et al., ACS Central Science (2025). DOI: 10.1021/acscentsci.5c01179)

Taste-Based Influenza Test Could Replace Nasal Swabs with Chewing Gum

Influenza is one of the most dangerous infectious diseases worldwide, claiming around half a million lives each year. What makes it particularly insidious is that flu viruses are contagious even before... Read more

$Image: The technology could be used for the early diagnosis of diseases such as cancers and Alzheimer\'s (Photo courtesy of PolyU)$

3D Micro-Printed Sensors to Advance On-Chip Biosensing for Early Disease Detection

Early-stage disease diagnosis depends on the ability to detect biomarkers with exceptional sensitivity and precision. However, traditional biosensing technologies struggle with achieving this at the micro-scale,... Read more

Industry

view channel

Bio-Rad and Biodesix Partner to Develop Droplet Digital PCR High Complexity Assays

Bio-Rad Laboratories (Hercules, CA, USA) and Biodesix (Louisville, CO, USA) have expanded their partnership agreement under which Biodesix will conduct the development, clinical validation, and regulatory... Read more

Hologic to be Acquired by Blackstone and TPG

Hologic (Marlborough, MA, USA) has entered into a definitive agreement to be acquired by funds managed by Blackstone (New York, NY, USA) and TPG (San Francisco, CA, USA) in a transaction valued at up to... Read more

Bio-Techne and Oxford Nanopore to Accelerate Development of Genetics Portfolio

Bio-Techne Corporation (Minneapolis, MN, USA) has expanded its agreement with Oxford Nanopore Technologies (Oxford, UK) to broaden Bio-Techne's ability to develop a portfolio of genetic products on Oxford... Read more

Terumo BCT and Hemex Health Collaborate to Improve Access to Testing for Hemoglobin Disorders

Millions of people worldwide living with sickle cell disease and other hemoglobin disorders experience delayed diagnosis and limited access to effective care, particularly in regions where testing is scarce.... Read more