We use cookies to understand how you use our site and to improve your experience. This includes personalizing content and advertising. To learn more, click here. By continuing to use our site, you accept our use of cookies. Cookie Policy.

Mammoth Biosciences Presents AACC 2021 Disruptive Technology Award Finalist CRISPR-Based Detection Platform

By LabMedica International staff writers
Posted on 29 Sep 2021

Illustration

Mammoth Biosciences (San Francisco, CA, USA) presented its revolutionary CRISPR-based detection platform that is enabling limitless testing possibilities and was also one of the AACC 2021 Disruptive Technology award finalists.

Mammoth has catalyzed a new approach to molecular diagnostics, called DETECTR. Based on CRISPR, this programmable platform acts as a search engine for biology and is capable of finding and identifying any nucleic acid sequence in the genome. Using proprietary technology licensed exclusively from the University of California, Berkeley and developed internally, Mammoth is working on multiple form factors and test targets from infectious diseases to cancer. For example, DETECTR was configured in less than two weeks to detect SARS-CoV-2, demonstrating the platform’s ability to be quickly tailored to identify any DNA or RNA target. The resulting product, DETECTR BOOST, is a reagent kit that when combined with standard laboratory automation provides labs with unparalleled high throughput molecular testing.

Mammoth was also one of the AACC 2021 Disruptive Technology award finalists. AACC's Disruptive Technology Award Competition recognizes innovative testing and disruptive technology solutions that improve patient care through diagnostic performance or access to high quality testing. It provides an opportunity for early to mid-stage start-ups in the medical device, diagnostic, or digital health/health IT spaces to showcase their technology and present to a large audience and a panel of judges.

Related Links:
Mammoth Biosciences

Visit expo >

Gold Member

Quantitative POC Immunoassay Analyzer

EASY READER+

Collection and Transport System
PurSafe Plus®

HBV DNA Test

GENERIC HBV VIRAL LOAD VER 2.0

Pipette

Accumax Smart Series

ADLM

Latest AACC 2021 News

Channels

Clinical Chemistry

view channel

Image: Schematic diagram of esophageal cancer cell identification research process (Photo courtesy of GE Dianlong)

VOCs Show Promise for Early Multi-Cancer Detection

Early cancer detection is critical to improving survival rates, but most current screening methods focus on individual cancer types and often involve invasive procedures. This makes it difficult to identify... Read more

Image: Portable Raman spectroscopy could help detect kidney disease at POC (Photo courtesy of Shutterstock)

Portable Raman Spectroscopy Offers Cost-Effective Kidney Disease Diagnosis at POC

Kidney disease is typically diagnosed through blood or urine tests, often when patients present with symptoms such as blood in urine, shortness of breath, or weight loss. While these tests are common,... Read more

Image: Mesoporous gold nanoparticles have unique biosensing capabilities (Photo courtesy of The University of Queensland)

Gold Nanoparticles to Improve Accuracy of Ovarian Cancer Diagnosis

Ovarian cancer is considered one of the deadliest cancers, in part because it rarely shows clear symptoms in its early stages, and diagnosis is often complex. Current approaches make it difficult to accurately... Read more

Simultaneous Cell Isolation Technology Improves Cancer Diagnostic Accuracy

Accurate cancer diagnosis remains a challenge, as liquid biopsy techniques often fail to capture the complexity of tumor biology. Traditional systems for isolating circulating tumor cells (CTCs) vary in... Read more

Molecular Diagnostics

view channel

New Diagnostic Method Detects Pneumonia at POC in Low-Resource Settings

Pneumonia continues to be one of the leading causes of death in low- and middle-income countries, where limited access to advanced laboratory infrastructure hampers early and accurate diagnosis.... Read more

Blood Immune Cell Analysis Detects Parkinson’s Before Symptoms Appear

Early diagnosis of Parkinson’s disease remains one of the greatest challenges in neurology. The condition, which affects nearly 12 million people globally, is typically identified only after significant... Read more

Image: A potential diagnostic and therapeutic target could transform ovarian cancer outcomes (Photo courtesy of Adobe Stock)

New Diagnostic Marker for Ovarian Cancer to Enable Early Disease Detection

Ovarian cancer remains the deadliest gynecological malignancy worldwide, responsible for more than 200,000 deaths annually. Unlike other cancers, ovarian cancer still lacks a reliable screening test.... Read more

Image: Professor Tatjana Crnogorac-Jurcevic identified specific proteins in urine that can serve as biomarkers of early stage pancreatic cancer (Photo courtesy of Barts Cancer Institute)

Urine Test Detects Early Stage Pancreatic Cancer

Pancreatic cancer remains among the hardest cancers to detect early. In the UK, around 10,000 people are diagnosed each year, but only 5% survive beyond five years. Late diagnosis is a major factor—more... Read more

Hematology

view channel

ADLM’s New Coagulation Testing Guidance to Improve Care for Patients on Blood Thinners

Direct oral anticoagulants (DOACs) are one of the most common types of blood thinners. Patients take them to prevent a host of complications that could arise from blood clotting, including stroke, deep... Read more

Viscoelastic Testing Could Improve Treatment of Maternal Hemorrhage

Postpartum hemorrhage, severe bleeding after childbirth, remains one of the leading causes of maternal mortality worldwide, yet many of these deaths are preventable. Standard care can be hindered by delays... Read more

Image: New research points to protecting blood during radiation therapy (Photo courtesy of 123RF)

Pioneering Model Measures Radiation Exposure in Blood for Precise Cancer Treatments

Scientists have long focused on protecting organs near tumors during radiotherapy, but blood — a vital, circulating tissue — has largely been excluded from dose calculations. Each blood cell passing through... Read more

Image: Platelets sequester cfDNA during circulation (Murphy L. et al., Science, 2025; DOI: 10.1126/science.adp3971)

Platelets Could Improve Early and Minimally Invasive Detection of Cancer

Platelets are widely recognized for their role in blood clotting and scab formation, but they also play a crucial role in immune defense by detecting pathogens and recruiting immune cells.... Read more

Immunology

view channel

Image: The new liquid biopsy model can predict patient response to immune checkpoint therapies (Photo courtesy of 123RF)

Blood-Based Liquid Biopsy Model Analyzes Immunotherapy Effectiveness

Immunotherapy has revolutionized cancer care by harnessing the immune system to fight tumors, yet predicting who will benefit remains a major challenge. Many patients undergo costly and taxing treatment... Read more

Image: The research provides the first detailed view of how immune cells expand during cancer treatment and how this process can be restored (Photo courtesy of Shutterstock)

Signature Genes Predict T-Cell Expansion in Cancer Immunotherapy

Modern cancer immunotherapies rely on the ability of CD8⁺ T cells to rapidly multiply within tumors, generating the immune force needed to eliminate cancer cells. However, the biological triggers behind... Read more

Molecular Microscope Diagnostic System Assesses Lung Transplant Rejection

Lung transplant recipients face a significant risk of rejection and often require routine biopsies to monitor graft health, yet assessing the same biopsy sample can be highly inconsistent among pathologists.... Read more

Blood Test Tracks Treatment Resistance in High-Grade Serous Ovarian Cancer

High-grade serous ovarian cancer (HGSOC) is often diagnosed at an advanced stage because it spreads microscopically throughout the abdomen, and although initial surgery and chemotherapy can work, most... Read more

Microbiology

view channel

High-Throughput Enteric Panels Detect Multiple GI Bacterial Infections from Single Stool Swab Sample

Gastrointestinal (GI) infections are among the most common causes of illness worldwide, leading to over 1.7 million deaths annually and placing a heavy burden on healthcare systems. Conventional diagnostic... Read more

Image: Sugar fingerprints open new possibilities for faster and more reliable diagnosis of fungal infections (Photo courtesy of 123RF)

Fast Noninvasive Bedside Test Uses Sugar Fingerprint to Detect Fungal Infections

Candida bloodstream infections are a growing global health threat, causing an estimated 6 million cases and 3.8 million deaths annually. Hospitals are particularly vulnerable, as weakened patients after... Read more

Image: A clinical test and handheld device could quickly classify sepsis patients into two groups (Photo courtesy of Sara Moser/WashU Medicine)

Rapid Sepsis Diagnostic Device to Enable Personalized Critical Care for ICU Patients

Sepsis is a life-threatening condition that occurs when the body’s response to infection spirals out of control, damaging organs and leading to critical illness. Patients often arrive at intensive care... Read more

Image: The CD Chip (top) and The CD² Chip (bottom) (Photo courtesy of YANG Xiao)

Microfluidic Platform Assesses Neutrophil Function in Sepsis Patients

Sepsis arises from infection and immune dysregulation, with neutrophils playing a central role in its progression. However, current clinical tools are unable to both isolate these cells and assess their... Read more

Pathology

view channel

Image: The artistic rendering depicts proteins (colored shapes) being analyzed by solid-state nanopores under varying voltage conditions (Photo courtesy of Sotaro Uemura/The University of Tokyo)

New Molecular Analysis Tool to Improve Disease Diagnosis

Accurately distinguishing between similar biomolecules such as proteins is vital for biomedical research and diagnostics, yet existing analytical tools often fail to detect subtle structural or compositional... Read more

Tears Offer Noninvasive Alternative for Diagnosing Neurodegenerative Diseases

Diagnosing and monitoring eye and neurodegenerative diseases often requires invasive procedures to access ocular fluids. Ocular fluids like aqueous humor and vitreous humor contain valuable molecular information... Read more

Image: The AI-based tool combines blood biomarkers and gene activity to more precisely track biological ageing (Photo courtesy of 123RF)

AI-Powered Method Combines Blood Data to Accurately Measure Biological Age

Chronological age tells us how many years we’ve lived, but not how quickly our bodies are ageing. Some people stay healthy well into their 80s or 90s, while others experience decline much earlier.... Read more

AI Tool Detects Cancer in Blood Samples In 10 Minutes

Detecting cancer recurrence or spread often depends on identifying rare tumor cells circulating in the bloodstream — a process known as a liquid biopsy. However, current methods rely on trained specialists... Read more

Technology

view channel

Cell-Sorting Device Uses Electromagnetic Levitation to Precisely Direct Cell Movement

Sorting different cell types—such as cancerous versus healthy or live versus dead cells—is a critical task in biology and medicine. However, conventional methods often require labeling, chemical exposure,... Read more

Image: Flowing red blood cells are imaged under the high-throughput QPM (Photo courtesy of W. Wang et al./Duke University)

Embedded GPU Platform Enables Rapid Blood Profiling for POC Diagnostics

Blood tests remain a cornerstone of medical diagnostics, but traditional imaging and analysis methods can be slow, costly, and reliant on dyes or contrast agents. Now, scientists have developed a real-time,... Read more

Image: The test will combine a serum with a liquid sample and apply it to the biosensor to quantify the virus at the RNA level (Photo courtesy of UCF College of Medicine)

Viral Biosensor Test Simultaneously Detects Hepatitis and HIV

Globally, over 300 million people live with Hepatitis B and C, and 40 million with HIV, according to WHO estimates. Diagnosing bloodborne viruses such as HIV and Hepatitis B and C remains challenging in... Read more

Image: The acoustofluidic device is designed for sample preparation and detection of small extracellular vesicles (Photo courtesy of Tony Jun Huang/Duke University)

Acoustofluidic Device to Transform Point-Of-Care sEV-Based Diagnostics

Rapid and sensitive detection of small extracellular vesicles (sEVs)—key biomarkers in cancer and organ health monitoring—remains challenging due to the need for multiple preprocessing steps and bulky... Read more

Industry

view channel

Qiagen Acquires Single-Cell Omics Firm Parse Biosciences

QIAGEN (Venlo, Netherlands) has entered into a definitive agreement to fully acquire Parse Biosciences (Seattle, WA, USA), a provider of scalable, instrument-free solutions for single-cell research.... Read more

Image: Puritan’s booth at the recent ADLM 2025 in Chicago, IL (Photo courtesy of Puritan)

Puritan Medical Products Showcasing Innovation at AMP2025 in Boston

Puritan Medical Products (Guilford, ME, USA), the world’s most trusted manufacturer of swabs and specimen collection devices, is set to exhibit at AMP2025 in Boston, Massachusetts, from November 11–15.... Read more

Image: This strategic merger brings together two industry leaders with complementary strengths (Photo courtesy of Advanced Instruments)

Advanced Instruments Merged Under Nova Biomedical Name

Advanced Instruments (Norwood, MA, USA) and Nova Biomedical (Waltham, MA, USA) are now officially doing business under a single, unified brand. This transformation is expected to deliver greater value... Read more

Bio-Rad and Biodesix Partner to Develop Droplet Digital PCR High Complexity Assays

Bio-Rad Laboratories (Hercules, CA, USA) and Biodesix (Louisville, CO, USA) have expanded their partnership agreement under which Biodesix will conduct the development, clinical validation, and regulatory... Read more