We use cookies to understand how you use our site and to improve your experience. This includes personalizing content and advertising. To learn more, click here. By continuing to use our site, you accept our use of cookies. Cookie Policy.

Mammoth Biosciences Presents AACC 2021 Disruptive Technology Award Finalist CRISPR-Based Detection Platform

By LabMedica International staff writers
Posted on 29 Sep 2021

Illustration

Mammoth Biosciences (San Francisco, CA, USA) presented its revolutionary CRISPR-based detection platform that is enabling limitless testing possibilities and was also one of the AACC 2021 Disruptive Technology award finalists.

Mammoth has catalyzed a new approach to molecular diagnostics, called DETECTR. Based on CRISPR, this programmable platform acts as a search engine for biology and is capable of finding and identifying any nucleic acid sequence in the genome. Using proprietary technology licensed exclusively from the University of California, Berkeley and developed internally, Mammoth is working on multiple form factors and test targets from infectious diseases to cancer. For example, DETECTR was configured in less than two weeks to detect SARS-CoV-2, demonstrating the platform’s ability to be quickly tailored to identify any DNA or RNA target. The resulting product, DETECTR BOOST, is a reagent kit that when combined with standard laboratory automation provides labs with unparalleled high throughput molecular testing.

Mammoth was also one of the AACC 2021 Disruptive Technology award finalists. AACC's Disruptive Technology Award Competition recognizes innovative testing and disruptive technology solutions that improve patient care through diagnostic performance or access to high quality testing. It provides an opportunity for early to mid-stage start-ups in the medical device, diagnostic, or digital health/health IT spaces to showcase their technology and present to a large audience and a panel of judges.

Related Links:
Mammoth Biosciences

Visit expo >

Platinum Member

Automated Coagulation Analyzer

Hemolumi H6

Gold Member

Nucleic Acid Extractor System

NEOS-96 XT

Automated Urinalysis Solution

UN-9000

New

Fully Automated Urinalysis System

DxU 1800 Fully Automated Urinalysis System

ADLM

Latest AACC 2021 News

Channels

Clinical Chemistry

view channel

Image: The test identifies individuals more likely to have elevated brain amyloid, with PET used for confirmation (Image Credit: Adobe Stock)

Study Evaluates Alzheimer’s Blood Biomarker Across Racial and Ethnic Groups

Alzheimer’s disease trials increasingly depend on identifying cognitively unimpaired people who already have elevated brain amyloid. Blood biomarkers may help reduce reliance on positron emission tomography... Read more

Image Credit: iStock

Blood Protein May Help Identify Treatment-Resistant Psychosis

Psychotic disorders, including schizophrenia, are diagnosed primarily through assessment of symptoms and behaviors such as hallucinations, delusions, and disordered thinking. Treatment-resistant psychosis... Read more

Image: Schematic illustration of the operating principle of the enzyme-reaction-based highly sensitive biosensor (ESGNS) (Credit: Chihyun Kim, Wonjun Jo, Dayoung Chang, et al. Enzymatic sialylation–driven gold nanostructured platform for rapid and selective detection of sialic acid–deficient transferrin. Chemical Engineering Journal, 2026. https://doi.org/10.1016/j.cej.2026.182244)

Electrochemical Biosensor Rapidly Detects Cerebrospinal Fluid Leaks

Cerebrospinal fluid surrounds the brain and spinal cord and helps protect them from physical impact. After severe head trauma or brain surgery, it can leak through skull defects and drain from the nose or ears.... Read more

Blood Protein Panel Supports Monitoring of Treated Celiac Disease

Celiac disease is an autoimmune condition in which gluten triggers intestinal inflammation that can damage the gut and impair nutrient absorption. Even with a gluten-free diet, some patients may continue... Read more

Molecular Diagnostics

view channel

Blood-Based Metagenomic Test Detects Wide Range of Pathogens from Single Sample

Infectious disease diagnosis can be challenging when the causative pathogen is unknown at the start of evaluation. Conventional testing may require multiple targeted assays, delaying answers for patients... Read more

Image: Seye Oladeji, graduate student and first author, holds up an example of a detection assay. (Photo courtesy of Rice University/Jared Jones)

New RNA Detection Tool Shows Promise for HIV and Other Viral Testing

RNA viruses such as human immunodeficiency virus (HIV) require assays that can detect very low levels of viral genetic material. Clinical and environmental testing can also expose enzymes to harsh assay... Read more

Image: The platform is designed to isolate extracellular vesicles originating from a selected tissue, with an initial focus on those released by hepatocytes in the liver. (Photo courtesy of Mursla Bio)

Tissue-Specific Vesicle Isolation Expands Molecular Insights Into Liver Disease

Liver disease can produce overlapping molecular signals from cirrhosis and hepatocellular carcinoma, complicating blood-based analysis. Liquid biopsy approaches that examine extracellular vesicles face... Read more

Image: GenomeNext uses a pangenome reference to better represent human genetic diversity and improve variant detection, while GenomeReveal integrates RNA analysis to help interpret certain DNA findings (Photo courtesy of Ambry Genetics)

Whole Genome Sequencing Solution Targets Unsolved Rare Disease Cases

Rare diseases often present persistent diagnostic challenges for patients and families. Many patients undergo years of testing without receiving a diagnosis, and even comprehensive genetic testing can... Read more

Hematology

view channel

Image Credit: Adobe Stock

New Donor Genetic Marker May Help Predict Stem Cell Transplant Success

Donor selection for hematopoietic stem cell transplantation plays a major role in relapse risk and survival for patients with blood cancers and other blood disorders. Despite advances in genotyping, uncertainty... Read more

Image Credit: American Society of Hematology

Updated Ferritin Thresholds Improve Detection of Iron Deficiency

Iron deficiency is one of the most common health conditions worldwide, yet its nonspecific symptoms can delay diagnosis for months. Variation in testing practices and ferritin thresholds may contribute... Read more

New Automated Hemostasis Systems Become Available Across US Laboratories

Hemostasis testing supports critical decisions in surgery, anticoagulation management, and the evaluation of bleeding and thrombotic disorders, but laboratories continue to face rising volumes and complex... Read more

Image: Acute myeloid leukemia is an aggressive blood cancer in which relapse remains a major challenge, making MRD detection critical for risk assessment and treatment planning (Image Credit: Shutterstock)

Variation in AML Residual Disease Testing Prompts Push for Standardization

Acute myeloid leukemia (AML) is an aggressive blood cancer in which relapse after therapy remains a persistent challenge, making measurable residual disease (MRD) detection central to risk assessment and... Read more

Immunology

view channel

FDA Approval Adds Automated Testing Option for Parvovirus B19 Serology

Human Parvovirus B19 is a highly contagious erythrovirus transmitted mainly through respiratory droplets and close contact. Diagnosis relies on IgM antibodies to detect active infection and IgG antibodies... Read more

Blood-Based Immune Aging Map Could Help Spot Disease Risk Earlier

Chronological age does not always reflect immune health or future disease risk. Two adults of the same age can have immune systems that age very differently, with some remaining resilient while others... Read more

Blood-Based Immune Signal Could Reveal Lung Cancer Risk Before Tumors Develop

Lung cancer remains difficult to detect before symptoms appear, when advanced disease is harder to treat. In the U.K., about 32,800 people die from lung cancer each year, and only 11.1% of those diagnosed... Read more

Prototype Point-of-Care Test Aims to Improve Neonatal Sepsis Diagnosis

Neonatal sepsis remains difficult to diagnose because early signs can resemble other newborn conditions. Diagnostic delays may increase the risk of complications, death, long-term adverse outcomes, and... Read more

Microbiology

view channel

Rapid Host-Response Test Aims to Predict Corticosteroid Benefit in Sepsis

Sepsis and severe infections are difficult to treat because patients with similar clinical presentations may have very different underlying immune responses. Corticosteroids are commonly used in severe... Read more

Oral and Lung Microbiome Changes Linked to Severe Long Covid Symptoms

Long Covid can involve persistent respiratory, cognitive, and gastrointestinal symptoms after acute infection, creating a difficult diagnostic and management challenge. Because COVID-19 initially affects... Read more

Image: A health worker from the Mfou District Hospital collects a blood sample for the study (Photo courtesy of Sandrine Nsango, PhD)

Study Finds Distinct Malaria Parasites Linked to Sickle Cell Trait Protection

Malaria remains one of the world’s deadliest infectious diseases and has affected humans throughout recorded history. In regions where malaria is common, human genetics have been shaped by the sickle cell... Read more

Rapid Urine Test Aids Diagnosis of Invasive Aspergillosis

Invasive aspergillosis is an uncommon mold infection in the general population but can pose serious risks for people with weakened immune defenses. Diagnosis can be difficult because existing approaches... Read more

Pathology

view channel

Molecular Testing Refines Barrett’s Esophagus Progression Risk Beyond Biopsy Findings

Barrett’s esophagus is a precancerous condition associated with increased risk of esophageal adenocarcinoma. Routine endoscopic biopsy findings guide surveillance and therapy, but histopathology may not... Read more

Updated Digital Pathology Platform Expands AI Integration for Cancer Diagnosis

Digital pathology is reshaping how laboratories manage case review, image analysis, and collaboration. As diagnostic workflows become more complex, pathology teams need platforms that can support digital... Read more

Image: Overview of the multiple-instance learning (MIL) workflow, in which each TMA core image is represented as a bag of patches that are encoded and aggregated to generate a slide-level prediction. (Giner F, Pastor-Naranjo Á, Meseguer P, et al. International Journal of Molecular Sciences, 2026. DOI: 10.3390/ijms27156864)

AI Histopathology Tool Distinguishes Ewing Sarcoma for Diagnosis

Ewing sarcoma is a rare malignant tumor that mainly affects children, adolescents, and young adults. It usually arises in bone but can also develop in soft tissue, where its microscopic appearance may... Read more

Rapid Mass Spectrometry Test May Aid Glioma Margin Decisions

Glioma brain tumors are highly infiltrative and can extend into nearby healthy brain tissue, making tumor margins difficult to define during surgery. Residual tumor cells may contribute to recurrence and... Read more

Technology

view channel

Laser-Based Swab Analysis Shows Promise for Detecting Disease-Linked Odor Patterns

Disease-related changes in volatile organic compounds can alter body odor, producing measurable patterns in exhaled breath and bodily fluids. Current analytical methods can be complex, time-consuming,... Read more

Image: Antibody-coated microscopic beads are introduced into a tiny flow channel containing blood plasma. Laser irradiation enhances their interaction with CEACAM-5, a colorectal cancer biomarker, causing the beads to assemble and generate a detectable signal. (Image Credit: Figure reproduced from Iida et al., Nanoscale Horizons(2026), DOI: 10.1039/d6nh00017g. Licensed under CC BY-NC 4.0.)

Laser-Enhanced Assay Boosts Sensitivity for Colorectal Cancer Biomarker Detection

Colorectal cancer is the third most commonly diagnosed cancer and the second leading cause of cancer-related death worldwide. Early detection remains critical, but cancer biomarkers can produce only faint... Read more

$Image: OGT\'s SureSeq next‑generation sequencing portfolio, designed for use with the Hamilton NGS STAR Line (Photo courtesy of Hamilton Company)$

New Automation Workflow Streamlines NGS Library Preparation for High-Volume Labs

Demand for next-generation sequencing (NGS) continues to rise as laboratories process growing sample volumes, yet library preparation remains labor-intensive and a frequent source of variability.... Read more

Image: ADLM recommends that emerging AI tools follow the same professional oversight, quality, validation, and monitoring standards as traditional clinical testing within CLIA’s existing framework (Image Credit: Adobe Stock)

ADLM Calls for CLIA Updates to Support Safe AI Use in Laboratory Medicine

Clinical laboratories increasingly use artificial intelligence to verify, interpret, and report results, but safeguards under the Clinical Laboratory Improvement Amendments (CLIA) were designed in 1992.... Read more

Industry

view channel

Global TB Summit Connects Diagnostic Testing With Prevention and Clinical Care

Tuberculosis remains a major global infectious disease challenge despite declining deaths. In 2024, an estimated 10.7 million people worldwide developed the disease and nearly 1.2 million died from it.... Read more

Image: The collaboration centers on the SwiftLab Platform and SpectroChip’s photonic chip-based portable testing technology (Photo courtesy of Pur

Hospital Partnership Advances Clinical Validation of Portable Diagnostic Technology

Point-of-care diagnostics can help hospitals obtain results closer to the patient, but many rapid tests provide only limited qualitative information. Central laboratory testing offers more precise analysis,... Read more

Agilent Acquisition of Proscia to Advance AI-Enabled Digital Pathology Workflows

Agilent Technologies Inc. has entered into a definitive agreement to acquire Proscia, a provider of digital pathology software for clinical and life-sciences customers. The all-cash transaction is valued... Read more

Diazyme Expands Chemistry Testing Portfolio With Alfa Wassermann Acquisition

Diazyme Laboratories, Inc., based in Poway, California, has acquired the business of Alfa Wassermann Diagnostic Technologies LLC from CARR Biosystems. Alfa Wassermann Diagnostic Technologies is a U.... Read more