We use cookies to understand how you use our site and to improve your experience. This includes personalizing content and advertising. To learn more, click here. By continuing to use our site, you accept our use of cookies. Cookie Policy.

LabMedica

Download Mobile App
Recent News Expo Medica 2024 Clinical Chem. Molecular Diagnostics Hematology Immunology Microbiology Pathology Technology Industry Focus

Study Showing Differing COVID-19 Antibody Profiles Among Vaccinated and Naturally Infected Individuals Presented at AACC 2021

By LabMedica International staff writers
Posted on 29 Sep 2021

A new study revealing how antibodies against the SARS-CoV-2 virus can vary among recipients of COVID-19 vaccines and naturally infected individuals was presented at the 2021 AACC Annual Scientific Meeting & Clinical Lab Expo.

In the new study, a research group at the University Hospitals Cleveland Medical Center (Cleveland, OH, USA) set out to define differences in antibodies against SARS-CoV-2 among vaccinated and unvaccinated individuals.


Illustration
Illustration

The scientists tested for antibodies against the SARS-CoV-2 spike protein, receptor-binding domain (RBD), nucleocapsid protein, and the spike protein’s S1 and S2 subunits in three study groups: 33 fully vaccinated healthcare workers, 52 healthcare workers who had recovered from natural infection, and 34 patients with active infections. The test results revealed that the fully vaccinated individuals had an average of 50-fold higher antibody levels than naturally infected, unvaccinated individuals. Antibodies from the vaccinated group also reacted far more strongly to the RBD and S1 viral antigens, suggesting that antibodies against these proteins could be the best targets for tests developed in the future.

Follow-up studies that profile changes in SARS-CoV-2 antibodies over time for vaccinated individuals and those with breakthrough infections could yield further insights, according to Xiaochun Zhang, MD, PhD, of University Hospitals Cleveland Medical Center. “With the third dose of mRNA vaccine on the horizon, this type of study may help identify practical indicator in optimizing booster-dose planning if an association between antibody level and infection risk is proved,” she said.

Related Links:
University Hospitals Cleveland Medical Center 


New
Gold Member
Pharmacogenetics Panel
VeriDose Core Panel v2.0
Gold Member
Turnkey Packaging Solution
HLX
New
Washer Disinfector
Tiva 8
New
Newborn Screening Test
NeoMass AAAC 3.0

Latest AACC 2021 News

Study Reveals Varying Antibody Responses and Adverse Reactions Among Recipients of Different COVID-19 Vaccines

Novel Study on Performance of Coronavirus Tests in Children Presented at 2021 AACC Annual Scientific Meeting

New Rapid Test That Identifies Deteriorating COVID-19 Patients with Greater Accuracy than Existing Tests Presented at AACC 2021