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Pathology

Image: The single cell gel electrophoresis assay or “comet” test (Photo courtesy of the Belgian BioElectroMagnetics Group).

Sensitivity of White Blood Cell DNA to Damage from UV Light Distinguishes Cancer Patients from Healthy Individuals

A simple test that measures the extent of damage to white blood cell DNA caused by exposure to ultraviolet light has the potential to detect individuals with cancer before the appearance of any detectable symptoms.  More...
13 Aug 2014
Image: The photomicrograph shows the appearance of a low grade carcinoma of the prostate that can be difficult to recognize as malignancy, particularly in small needle biopsies (Photo courtesy of the University of Washington).

Accurate Epigenetic Test Eliminates Superfluous Biopsies for Prostate Cancer

Two independent trials have now validated the performance of an epigenetic test that could provide physicians with a better tool to help eliminate unnecessary repeat prostate biopsies.  More...
06 Aug 2014

Mutation That Induces High Blood Pressure in Women Linked to Increased Heart Attack Risk

A mutation in women in the G-protein coupled estrogen receptor 30 gene generates a receptor with reduced activity that induces high blood pressure, the single biggest risk factor for heart attack and stroke.  More...
05 Aug 2014
Image: The Qubit 2.0 fluorometer (Photo courtesy of Invitrogen).

Innovative Methodology Translates Noncoding DNA in Colorectal Cancer

Although the genetic origins of cancers have been studied for a long time, scientists were not able to measure the role of noncoding regions of the genome until now.  More...
05 Aug 2014
Image: Histopathology of a child’s kidney showing one glomerulus (arrow) with matrix expansion and uniform thickening of the basement membrane. The tubules show mild atrophy and the interstitium contains patchy moderate infiltrates. The appearance is consistent with membranous nephropathy (Photo courtesy of Dr. S. K. Pradhan).

Genetic Test Predicts Therapeutic Response in Pediatric Kidney Disease

Genetic mutations in the kidney’s filtration barrier are frequently linked with a lack of response to immunosuppressive treatments among children with sporadic nephrotic syndrome.  More...
05 Aug 2014
Image: Papillary thyroid cancer showing grey lobulated tumor with central scar (Photo courtesy of Dr. Shahidul Islam).

Molecular Test Effectively Guides Extent of Initial Thyroidectomy

The routine use of a molecular testing panel increases the likelihood of performing the correct initial surgery for patients with thyroid nodules and cancer.  More...
05 Aug 2014
Image: Microscopic analysis system automatically acquires up to eight slides with immunohistochemically stained sections and performs quantitative analysis of staining intensities (Photo courtesy of TissueGnostics).

New Technology Developed to Diagnose Cancer Cells

Patient tumors can be analyzed for aberrant activations of core cancer pathways by monitoring based on biomarker expression which ensures efficient treatment in targeted therapy.  More...
04 Aug 2014
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The Pathology channel details advances in the field of Surgical Pathology and all its subspecialties, including Cytopathology and its subspecialties.
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