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Pathology

Image: Electron micrograph showing an increased number of mitochondria in the subsarcolemmal space from a patient with mitochondrial myopathy (Photo courtesy of the Virginia Commonwealth University).

Myopathy Diagnosis Improved by New Gene Mutation

A new gene mutation has been discovered which will help doctors give a more accurate diagnosis of a particular type of brain and muscle disease in children.  More...
08 Jan 2014
Image: PCR products of methylenetetrahydrofolate reductase C677T DNA samples extracted with magnetic nanoparticles using saliva samples (lanes 1-5) and with traditional methods using blood samples (lanes 7-11) (Photo courtesy of Neural Regeneration Research).

Analysis of Saliva DNA Suggested for Screening Stroke-Linked Mutation

Results of real-time PCR analysis of saliva samples from stroke patients and normal controls obtained using a noninvasive magnetic nanoparticle-based technique were consistent with those from conventionally treated blood samples, which had been taken at the same time.  More...
06 Jan 2014

Critical Enzyme Predicts Onset of Alzheimer Disease

The critical enzyme beta-secretase1 is known to be elevated in brains with sporadic Alzheimer disease and two of the major pathological characteristics of AD are neuritic plaques and neurofibrillary tangles, which are used to diagnose or confirm AD at autopsy.   More...
02 Jan 2014
Image: A linear ion trap - Fourier transform ion cyclotron resonance mass spectrometer (MALDI FTICR MS) similar to that used in the gastric cancer glycomics study (Photo courtesy of Wikimedia Commons).

Glycomic Analysis Distinguishes Gastric Cancer from Diseases with Similar Symptoms

Analysis of complex sugars in serum samples enabled diagnosticians to distinguish patients with gastric cancer from those with gastritis or duodenal ulcers.  More...
30 Dec 2013
Image: Bone marrow aspirate smear from a patient with chronic myelomonocytic leukemia, a myeloproliferative neoplasm (Photo courtesy of M.Yared).

Molecular Test Detects Difficult-to-Diagnose Chronic Blood Cancer

The current blood test used to diagnose blood cancer works by identifying mutation in a specific gene; however, it is not necessary that the gene should be present in every patient.  More...
26 Dec 2013
Image: Normal brain (left) compared with one from a severe case of Alzheimer’s disease (right) (Photo courtesy of US National Institute on Aging).

Rare Gene Variants Doubles Alzheimer's Disease Risk

Variations in a gene have been identified that doubles a person's risk of developing Alzheimer's disease later in life.    More...
26 Dec 2013
Image: Breast carcinoma HER2 (4B5) positive, Score: 3+ Magnification: 40X (Photo courtesy of Ventana).

HER2 Companion Diagnostic Test Helps Identify Patients for Two Additional Targeted Medicines

A new use of an HER2 assay can now also help identify breast cancer patients suitable for two additional HER2-targeted medicines, coinciding with therapy availability in many countries.  More...
25 Dec 2013
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The Pathology channel details advances in the field of Surgical Pathology and all its subspecialties, including Cytopathology and its subspecialties.