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Pathology

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Blood Samples Analysis Monitors Colorectal Cancer Chemotherapy Response

Circulating cell-free DNA may be collected from plasma of colorectal cancer patients and represents a less invasive, less costly approach to tracking biomarkers of interest longitudinally and at progression.  More...
18 Nov 2015
Image: The Cologuard multi-target stool DNA test kit (MT-sDNA) for colorectal cancer screening (Photo courtesy of Exact Sciences Corporation).

Screening Stool DNA Test Detects Colorectal Cancer

The accuracy of a multi-target stool DNA test compared with fecal immunochemical testing for hemoglobin for detection of screening-relevant colorectal neoplasia in Alaska Native people has been assessed.   More...
16 Nov 2015
Image: Schematic diagram of circulating tumor DNA (ctDNA), a small piece of DNA released from dying cancer cells into the blood (Photo courtesy of Jonathan Bailey).

Cancer DNA in Blood Helps Personalize Liver Cancer Treatment

Liver cancer tumor specimens are difficult and sometimes dangerous to obtain, and noninvasive methods are required to assess cancer progression and characterize underlying genomic features.  More...
15 Nov 2015
Image: Mucocutaneous papilloma manifestations around the nose of an autosomal dominant condition known as Cowden syndrome (Photo courtesy of University of Sao Paulo).

Predisposing Gene Associated With Cowden Syndrome

A new gene has been discovered that is associated with Cowden syndrome, an inherited condition that carries high risks of thyroid, breast, and other cancers, and a subset of non-inherited thyroid cancers.  More...
15 Nov 2015
Image: Molecular model of the prostate cancer drug abiraterone (Photo courtesy of Wikimedia Commons).

Analysis of Circulating DNA Predicts Prostate Cancer's Development of Drug Resistance

Analysis of prostate cancer DNA circulating in the bloodstream identifies a mutation that indicates whether the tumor will become resistant to the drug-of-choice abiraterone, and enables the physician to choose an alternative treatment.  More...
15 Nov 2015
Image: Histopathology of a testicular germ cell tumor consisting of teratoma, embryonal carcinoma yolk sac tumor and syncytiotrophoblasts (Photo courtesy of Lee Moffitt Cancer Center).

Four Susceptibility Loci Identified for Testicular Germ Cell Tumor

Testicular germ cell tumor is the most common cancer in men aged 15 to 45 years, with over 18,000 new cases diagnosed annually in Europe and the incidence of TGCT has approximately doubled over the last four decades in Western Europe, which implicates environmental or lifestyle factors as risk determinants.  More...
08 Nov 2015
Image: Immunohistochemistry of αB-crystallin protein expression in a human breast tumor (Photo courtesy of University of Wisconsin).

Test Predicts Whether Breast Cancer Metastasizes to the Brain

Women can live for years with breast cancer that has begun to spread around the body, but the exception is when the cancer spreads to the brain, which usually indicates a woman is in her last few months of life.   More...
08 Nov 2015
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The Pathology channel details advances in the field of Surgical Pathology and all its subspecialties, including Cytopathology and its subspecialties.
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