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Pathology

Image: Predicted secondary structure and sequence conservation of SNORA42 (Photo courtesy of Wikimedia Commons).

Elevated Levels of Small Nucleolar RNA Predict More Aggressive Colorectal Cancer

High levels of the small nucleolar RNA SNORA42 in patients with colorectal cancer have been shown to indicate that the patient may have a tumor that is especially aggressive, resistant to treatment, and prone to migrate and metastasize.  More...
26 Oct 2015
Image: Histopathology of pancreatic cancer showing a main-duct type intraductal papillary mucinous neoplasm (IPMN) with a focus of high-grade dysplasia compatible with malignant IPMN with carcinoma-in-situ (Photo courtesy of National Cancer Center. Singapore).

Noninvasive Blood Test Detects Pancreatic Cancer Biomarkers

For the prognosis of patients with pancreatic cancer, new biomarkers are required for earlier, pre-symptomatic diagnosis and as epigenetic mutations take place at the earliest stages of tumorigenesis and they offer new approaches for detecting and diagnosing disease.  More...
25 Oct 2015
Image: In Roche’s Cervical Cancer Screening Portfolio, the “CINtec p16 Histology” immunohistochemistry assay detects p16-INK4a in cervical biopsy preparations. The figure illustrates that in cells with transforming HPV infections, HPV viral oncoprotein E7 impairs the function of pRB, disrupting its ability to bind to E2F. This leads to deregulated cell proliferation, genetic instability, and p16 over-expression detectible by immunohistochemistry staining (Image courtesy of Ventana, of Roche).

Screening Portfolio Protects Patients from Cervical Cancer and Overtreatment

A new portfolio of clinically validated genetic and pathology tests for human papillomavirus cervical cancer screening and diagnosis helps identify women at high risk of developing this highly preventable disease, which is nevertheless still classified as the 4th most frequent cancer in women—530,000 new cases annually, of which about half the patients die.  More...
20 Oct 2015
Image: Histopathology of an adrenal incidentaloma showing the pushing border between the adenoma and the surrounding parenchyma (arrows) (Photo courtesy of the Government of Western Australia).

Novel Urinary Biomarkers May Indicate Adrenal Cancer

A global analysis of metabolites and small molecules in urine samples from patients with adrenal cancer has identified four biochemicals that, when measured together, can distinguish malignant from benign adrenal tumors.   More...
19 Oct 2015
Image: Histopathology of metastatic renal cell carcinoma (Photo courtesy of Dr. Mark R. Wick).

Screening Test Predicts Treatment Response in Metastatic Kidney Cancer

Expression levels of a key protein involved in tumor cell survival appear to predict response to standard first-line therapy in patients with metastatic clear cell renal cell carcinoma.  More...
18 Oct 2015
Image: CAL2 stained megakaryocytes with CALR mutations in essential thrombocythemia (ET), primary myelofibrosis (PMF). The CAL2 immunostaining correlated 100% with the Sanger sequencing (Photo courtesy of DIANOVA).

New Antibody Improves Diagnosis of Myeloproliferative Neoplasms

When hematopoietic myeloid cells change malignantly in the bone marrow, this can lead to an uncontrolled proliferation of certain blood cells and humans then suffer from diseases that are referred to by the collective term myeloproliferative neoplasms.  More...
14 Oct 2015
Image: Schematic representation of analysis of breath samples for the diagnosis of ovarian cancer (Photo courtesy of Technion).

Compounds Detected in Breath Samples Specific to Ovarian Cancer

Diagnosing cancer today usually involves various imaging techniques, examining tissue samples under a microscope, or testing cells for proteins or genetic material.   More...
13 Oct 2015
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The Pathology channel details advances in the field of Surgical Pathology and all its subspecialties, including Cytopathology and its subspecialties.
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