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Pathology

Image: Odyssey Infrared Imaging System allows multiplex Western Blotting and accurate protein quantification using fluorescent dyes conjugated to secondary antibodies (Photo courtesy of LI-COR).

Human Polyomaviruses Screened in Cancer Samples

A new method to screen tumor samples for the presence of any Human polyomavirus has been created and although human polyomaviruses are commonly found in the population, they generally do not produce noticeable symptoms.  More...
06 Mar 2016
Image: Photomicrograph of metastatic breast cancer cells (Photo courtesy of the [US] National Cancer Institute).

Elevated Levels of Guanine Nucleotide Exchange Factors in Circulating Tumor Cells Predict Poor Outcome for Colorectal Cancer Patients

Cancer researchers have found that elevated expression of guanine nucleotide exchange factors in circulating tumor cells isolated from the peripheral circulation of patients with metastatic colorectal cancer was associated with shorter progression-free survival.  More...
06 Mar 2016
Image: Schematics of EFIRM technology for the detection of EGFR mutations in the bodily fluids of lung cancer patients. The cyclic-square wave of the electrical field (csw E-field) was applied to release and detect the EGFR mutations. EGFR sequences were measured on the electrochemical sensor with a capture probe precoated in conducting polymer (Photo courtesy of University of California-Los Angeles).

Novel Saliva Test Identifies and Tracks Cancer

A rapid, accurate test that can detect biomarkers of lung cancer in saliva is soon to be trialed in patients and the test takes only 10 minutes to give a result and could be done in the doctor's office.  More...
02 Mar 2016
Image: Histopathology of advanced bowel adenocarcinoma in which the glands are much larger and filled with necrotic debris (Photo courtesy of University of Utah School of Medicine).

Test Helps Select Best Treatment for Bowel Cancer Patients

Doctors usually treat advanced bowel cancer, also known as colorectal cancer, with chemotherapy but sometimes the first course of chemotherapy does not work and they need to give a different type of chemotherapy known as second line of treatment.   More...
01 Mar 2016
Image: Immunohistochemistry showing in situ hybridization positive for human papilloma virus HPV16/18 in this anal carcinoma histology specimen (Photo courtesy of International Agency for Cancer Research).

Human Papillomavirus Infection Connected to Anal Cancer

The prevalence of abnormal anal cytology and high-risk human papillomavirus among women with a history of HPV-related genital neoplasia with women without a history of HPV-related genital neoplasia has been compared.   More...
29 Feb 2016
Image: A blood test for DNA methylation levels of the gene encoding zinc finger protein 154 (ZNF154) can diagnose common cancers (Photo courtesy of US National Institutes of Health).

Blood Test Developed to Detect Five Early-Stage Cancers

A blood test to diagnose common types of cancer is in development after it was found that five forms of the disease share a telltale chemical signature.  More...
28 Feb 2016
Image: Histopathology of metastatic carcinoma in liver tissue from a patient with colorectal cancer (Photo courtesy of Nikon).

Tumor Biopsies with Blood Monitoring Show Lesion-Specific Response

Metastatic tumors driven by drug-targetable genetic mutations become resistant to a targeted therapy drug and the usual practice is to biopsy a single metastatic lesion to test for new mutations that can guide the selection of next-line therapies.   More...
24 Feb 2016
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The Pathology channel details advances in the field of Surgical Pathology and all its subspecialties, including Cytopathology and its subspecialties.
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