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Pathology

Image: The CELLSEARCH semi-automatic system that can capture and quantify circulating tumor cells (Photo courtesy of Janssen Diagnostics).

Arterial Blood Liquid Biopsy Detects Circulating Melanoma Cells

Venous blood collection is simple and minimally invasive, and this approach has made circulating tumor cells testing readily available to many cancer patients. The major drawback is the fact that CTCs are not always detectable for patients with clinically evident metastatic disease.   More...
06 Oct 2015
Image: The replacement of the amino acid arginine by a cysteine at position 117 in POT1p.R117C produces conformational changes in the protein that are incompatible with an efficient connection to the telomere, inducing an aberrant telomere elongation and fragile telomeres in the mutated cells (Photo courtesy of CNIO).

Mutated Gene Found in Families with Multiple Tumors

Cardiac angiosarcoma is a rare but malignant disease and in the case of hereditary CAS, the median survival expectancy is only four months because the disease is diagnosed at an advanced stage.   More...
05 Oct 2015
Image: Histopathology of prostate cancer; glomerulations demonstrating significant morphologic overlap with and transition to cribriform Gleason pattern 4 carcinoma (Photo courtesy of Memorial Sloan-Kettering Cancer Center).

Urine Liquid Biopsy Test Detects High-Grade Prostate Cancer

New screening methods that can add predictive diagnostic value for aggressive prostate cancer are needed to reduce unnecessary biopsies for patients with non-aggressive PCa.  More...
04 Oct 2015
Image: Nucleosomics Technology: The DNA in every cell is wound around protein complexes in a beads-on-a-string structure. Each bead is called a nucleosome. When cells die, the body breaks the DNA string up into individual nucleosomes which are released into the blood (Photo courtesy of VolitionRx Limited).

NuQ Blood Assay CE-Marked for Colorectal Cancer Detection

A blood-based diagnostic assay for detection of colorectal cancer has received Conformité Européenne marking, which enables European Clinical Use/Sale in 33 Countries with nearly 600 million people.  More...
04 Oct 2015
Image: The NanoDrop 8000 UV-Vis Spectrophotometer (Photo courtesy of Thermo Scientific).

DNA Alterations Identified Occur Earliest in Lung Cancer Development

Lungs resected for adenocarcinomas often harbor minute discrete foci of cytologically atypical pneumocyte proliferations designated as atypical adenomatous hyperplasia, which may represent an initial step in the progression to adenocarcinoma in situ.  More...
30 Sep 2015
Image: Scanning electron micrograph of human prostate cancer cells (Photo courtesy of University of Sheffield).

Blood Types Correlate with Survival After Prostate Cancer Vaccine

Simple, inexpensive strategies to target treatment to likely responders could substantially improve efficacy while simultaneously reducing health care costs, but identification of reliable biomarkers has proven challenging.   More...
29 Sep 2015
Image: SensiFAST SYBR No-ROX Kit developed for fast, highly reproducible real-time Polymerase Chain Reactions (PCR) (Photo courtesy of Bioline).

Micro Ribonucleic Nucleic Acid Panel Assays Launched

A novel approach has been developed by combinations of micro ribonucleic nucleic acid specific reverse transcriptase and hemi-nested real-time polymerase chain reaction primers that have been designed to maximize miRNA detection sensitivity and specificity.  More...
28 Sep 2015
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The Pathology channel details advances in the field of Surgical Pathology and all its subspecialties, including Cytopathology and its subspecialties.
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