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Pathology

Image: Luminescent conjugated oligothiophene, h-FTAA staining of tissue showing amyloid deposits, yellow red fluorescence (Photo courtesy of Linköping University).

Sensitive Method Detects Early Amyloidosis in Humans

The amyloidoses comprise a large group of diseases characterized by extracellular deposits in various tissues and organs. These deposits, termed “amyloid,” result from misfolding and/or partial unfolding of proteins followed by their ordered aggregation into amyloid fibrils with specific β-sheet conformation.  More...
03 Apr 2016
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Novel Blood Test Developed for Alzheimer's Diagnosis

A blood test has been developed that may potentially facilitate detection of Alzheimer's disease at an early stage and it is based on an immuno-chemical analysis using an infrared sensor.   More...
30 Mar 2016
Image: Schematic diagram of circulating methylated cell free DNA (Photo courtesy of Huntsman Cancer Institute).

Multiple Diseases Detected via DNA Released from Dying Cells

A blood test has been developed that can detect multiple pathologies, including diabetes, cancer, traumatic injury and neurodegeneration, in a highly sensitive and specific manner. The novel method infers cell death in specific tissue from the methylation patterns of circulating DNA that is released by dying cells.   More...
30 Mar 2016
Image: Histopathology of prostate cancer showing medium-sized cribriform gland with somewhat irregular luminal spaces (on left) that would be assigned Gleason pattern 4 (Photo courtesy of European Urology).

Prostate Cancer Diagnosed from Urinary Ribonucleic Acid

A test for noncoding ribonucleic acid molecules in urine may offer a way to detect prostate cancer that is more accurate and reliable than current methods using biomarkers such as prostate-specific antigen and prostate cancer gene 3.  More...
29 Mar 2016

Automated Microfluidic Device Simultaneously Detects HIV RNA and Antibodies

Diagnostic laboratories now have available a fully automated molecular testing device that simultaneously detects host anti-HIV antibodies and viral RNA in a single specimen of saliva or blood.    More...
27 Mar 2016
Image: Blood smear showing a segmented neutrophil and a mature lymphocyte with a single large nucleus (Photo courtesy of the University of Utah Medical School).

Early Stage Breast Cancer Recurrence Linked to High Leukocyte Ratio

A high ratio of two types of immune system cell is linked to an increased risk of disease recurrence after a diagnosis of early stage breast cancer and the findings might guide future treatment and monitoring strategies, if prospective studies confirm the link.  More...
23 Mar 2016
Image: Histopathology of the architecture of the lung in idiopathic pulmonary fibrosis (IPF) is characterized by a so-called “honeycomb” pattern with airways separated by bands of inflamed fibrous connective tissue and to a lesser extent, smooth muscle (Photo courtesy of Dr. Robert Dunstan).

Blood Test Accurately Detects Idiopathic Pulmonary Fibrosis

Idiopathic Pulmonary Fibrosis is a chronic, progressive and lethal lung disease characterized by scarring and reduction in the lungs' capacity to absorb oxygen. In the USA, around 100,000 people are currently affected by IPF, with approximately 30,000 to 40,000 new cases diagnosed each year.  More...
23 Mar 2016
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The Pathology channel details advances in the field of Surgical Pathology and all its subspecialties, including Cytopathology and its subspecialties.
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