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Pathology

Image: Erlotinib bound to EGRF at 0.26 nm resolution; surface color indicates hydrophobicity (Photo courtesy of Wikimedia Commons).

Analysis of Circulating Free DNA May Replace Tumor Biopsy for Detection of Non-Small-Cell Lung Cancer

A recent paper showed that analysis of circulating free DNA in blood samples could replace biopsy as a means for detecting patients with advanced non-small-cell lung cancer that was distinguished by oncogenic epidermal growth factor receptor mutations.  More...
10 Mar 2015
Image: Immunohistochemistry for alpha-synuclein showing positive staining (brown) of an intraneural Lewy-body in the substantia nigra in Parkinson\'s disease (Photo courtesy of the Michael J. Fox Foundation).

Skin Test Helps Diagnose Alzheimer's and Parkinson's Diseases

Skin biopsies can be used to detect elevated levels of abnormal proteins found in Alzheimer's and Parkinson's Diseases and may shed new light on both.  More...
08 Mar 2015

Aggressive Bladder Cancers May Be Identified by Measuring Two Urinary Proteins

British cancer researchers have found that measuring the urinary proteins epidermal growth factor receptor and epithelial cell adhesion molecule may represent a simple and useful approach for diagnosing and treating patients with the most aggressive bladder cancers.  More...
08 Mar 2015
Image: Various types of leukocytes within a blood sample used for a differential white blood cell count to determine the relative percentages (Photo courtesy of Dr. Kristine Krafts MD).

Blood Tests Help Identify Children Who Need Appendectomy

Appendicitis is the most common abdominal surgical emergency in the pediatric population, yet the diagnosis remains challenging in many cases and the use of laboratory data as a diagnostic adjunct has similarly been associated with relatively low sensitivity, and children with pathology-proven appendicitis can often present with a normal leukocyte count  More...
04 Mar 2015
Image: The Colox test kit for the detection of colorectal cancer (Photo courtesy of Diagnoplex SA).

Blood-Based Molecular Test Improves Early Detection of Colorectal Cancer

A convenient blood test can be ordered by a physician during a routine medical checkup to accurately and reliably detect both adenomatous polyps and early stages of colorectal cancer.  More...
03 Mar 2015
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Gene Test Matches Treatment to Patients with Cancer of Unknown Origin

Cancer of unknown origin is defined as a tumor from a patient presenting with metastatic carcinoma that did not unequivocally originate from a confirmed primary site on the basis of available diagnostic methods.   More...
02 Mar 2015
Image: Micrograph of hepatocellular carcinoma taken from a liver biopsy and colored with trichrome stain (Photo courtesy of Wikimedia Commons).

Analysis of Isotope Imbalance May Aid Liver Cancer Diagnosis

A novel approach for diagnosing liver cancer is based on analytical methods frequently used in the earth sciences.  More...
01 Mar 2015
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The Pathology channel details advances in the field of Surgical Pathology and all its subspecialties, including Cytopathology and its subspecialties.