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Pathology

Image: The LSM 710 confocal microscope (Photo courtesy of Carl Zeiss).

Glycan-Attaching Enzyme Defines Colon Cancer

An enzyme that is absent in healthy colon tissue but abundant in colon cancer cells and this enzyme appears to drive the conversion of normal colon tissue into cancer by attaching sugar molecules, or glycans, to certain proteins in the cell. More...
08 Feb 2018
Image: Histopathology of Endometriosis of the Fallopian Tube (Luminal Pattern). In this pattern, the normal complex, folded tubal mucosa is replaced by flat columnar epithelium with a tin underpinning of specialized endometrial stroma. There are also blood cells in the lumen Photo courtesy of Dr. Ed Uthman).

Genetic Biomarkers Determine Risk of Developing Endometriosis

Endometriosis is one of the most common women's health disorders, causing up to 10% of reproductive-age women to experience painful periods and potential infertility. Diagnosis can elude patients for decades, in part because exploratory surgery is considered the ultimate diagnostic method. More...
07 Feb 2018
Image: (A) Histology of a case of olfactory neuroblastoma with upregulation of CD24 gene by microarray, (B) confirmed by CD24 protein overexpression in the tumor cells (Photo courtesy of Caris Life Sciences).

Analysis Offers Treatment Options for Olfactory Neuroblastoma

Olfactory neuroblastoma (ONB) is a rare, locally aggressive, malignant neoplasm originating in the olfactory epithelium in the nasal vault. The recurrence rate of ONB remains high and there are no specific treatment guidelines for recurrent/metastatic ONBs. More...
01 Feb 2018
Image: The BD FACS CANTO II multiparameter flow cytometer (Photo courtesy of BD Biosciences).

Genetic Mutation Linked to Crohn's and Parkinson's Diseases

The inflammatory bowel diseases (IBD) are composed of two major subtypes, Crohn’s disease (CD) and ulcerative colitis (UC), which are distinguished by the distribution of chronic inflammatory changes. More...
31 Jan 2018

Polygenic Score Predicts Prostate Cancer Development

Currently, detection of prostate cancer relies primarily upon the prostate-specific antigen (PSA) screening blood test, but PSA testing is not very good as a screening tool. While it reduces deaths from prostate cancer, indiscriminate PSA screening also produces false positive results and encourages over-detection of non-aggressive, slow-growing tumors. More...
31 Jan 2018
Image: The FDA-approved BRACAnalysis CDx test as a companion diagnostic (Photo courtesy of Myriad Genetics).

Lab-Developed Tests Compared with Approved Diagnostics

The debate about the role of the government-approved diagnostics in the regulation of laboratory-developed tests (LDTs) has focused attention on the analytical performance of all clinical laboratory testing. More...
30 Jan 2018
Image: A diagram of the loss of an androgen-inactivating and isoform-specific HSD17B4 splice form enables emergence of castration-resistant prostate cancer (Photo courtesy of the Lerner Research Institute).

New Gene Variant Linked to Prostate Cancer

Prostate cancer (PCa) is the most commonly diagnosed malignancy and the second leading cause of cancer-related death in men in the USA. The growth and survival of PCa cells are driven by androgens through activation of the androgen receptor (AR) and its target genes. More...
30 Jan 2018
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The Pathology channel details advances in the field of Surgical Pathology and all its subspecialties, including Cytopathology and its subspecialties.