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Pathology

Image: Immunohistochemical stain for CD137 performed on paraffin-embedded tissue sections (cytoplasmic and membranous) using monoclonal BBK-2 clone (original magnification ×400) (Photo courtesy of Peter N. Carbone, MD and Qian-Yun Zhang, MD, PhD).

Immunohistochemical Stain Facilitates cHL Diagnosis

Remarkable efforts are underway to exploit classic Hodgkin lymphoma's (cHL) complex interplay of molecular alterations, loss of B-cell programming, and dependency of tumor microenvironment. More...
11 Mar 2019
Image: The Accuri C6 compact flow cytometer (Photo courtesy of BD Biosciences).

Cervical Microbes Potentially Tied to Infections and Lesions

Nearly all cervical cancers are causally associated with human papillomavirus (HPV). The burden of HPV-associated dysplasias in sub-Saharan Africa is influenced by human immunodeficiency virus (HIV). More...
07 Mar 2019
Image: A histopathology of the bile duct of a patient with biliary atresia: loss of bile ducts, brisk ductular reaction, and bile plugs (Photo courtesy of Hopkins GI Pathology).

Genetic Defect Linked to Pediatric Liver Disease

Biliary atresia (BA) is the most common cause of end‐stage liver disease in children and the primary indication for pediatric liver transplantation, yet underlying etiologies remain unknown. More...
04 Mar 2019
Image: A histopathology of gastric adenocarcinoma representing a signet ring cell variant identified in an endoscopic biopsy specimen (Photo courtesy of KGH).

Gastric Cancer Analysis Identifies Four Subtypes

In previous studies of gastric cancers (GCs), genomic and transcriptomic analyses have identified molecular signatures associated with phenotypes of the disease, such as patient subtypes and survival. New proteogenomic analysis of diffuse gastric cancers (GCs) in young populations identified four subtypes of the disease. More...
28 Feb 2019
Image: The Nextera DNA Library Preparation Kit (Photo courtesy of Illumina).

Gene Missense Variant Associated with Crohn's Disease

Gene-microbiome interactions are important in etiology and pathogenesis of inflammatory bowel disease, a chronic inflammatory disorder of the gastrointestinal tract consisting of Crohn’s disease and ulcerative colitis. More...
21 Feb 2019
Image: The Affymetrix high-resolution microarray scanner 3000 (Photo courtesy of Thermo Fisher Scientific).

MicroRNAs Provide Clues in Primary CNS Lymphoma

Primary central nervous system lymphoma (PCNSL), a rare subgroup of diffuse large B-cell lymphoma (DLBCL) arising in the central nervous system (CNS), is an aggressive malignant variant of nodal non-Hodgkin lymphoma (NHL). More...
20 Feb 2019
Image: A colored scanning electron micrograph (SEM) of a Helicobacter pylori bacterium (red) in the stomach (Photo courtesy of Steve Gschmeissner / SPL).

Atrophic Gastritis Prevalence Determined by Serological Evidence

Gastric cancer, among the most common cancers, is a leading cause of cancer deaths worldwide. More...
19 Feb 2019
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The Pathology channel details advances in the field of Surgical Pathology and all its subspecialties, including Cytopathology and its subspecialties.
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