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Pathology

Image: The QX200 Droplet Digital PCR System provides absolute quantification of target DNA or RNA molecules (Photo courtesy of Bio-Rad Laboratories).

HPV DNA Test Monitors Remission in Oral Cancer

A blood-based method has been developed to test patients with human papillomavirus-associated oral cancers for signs of remission or recurrence. This approach would potentially allow doctors to more accurately and more easily identify which patients are free from cancer after radiation treatment, and which might be poised to recur. More...
06 Nov 2018
Image: The WITec alpha 300AR confocal Raman microscope (Photo courtesy of WITec).

Resistance of Tumor Cells to Cancer Drugs Detected

Acquired resistance is developing during treatment of cancer patients who were initially responding to the therapy. Drug resistance is mediated by mutations acquired during therapy, in addition to other adaptive responses. More...
06 Nov 2018
Image: Disseminated tumor cells (DTCs) stained by double immunofluorescence (AE1AE3/NR2F1 and AE1AE3/Ki67) and correlation between Ki67 and NR2F1 expression (Photo courtesy of the Icahn School of Medicine at Mount Sinai).

Dormant Disseminated Tumor Cells Stratified in Breast Cancer Patients

Breast cancer patients may experience relapse and subsequent death from the disease many years after primary treatment. This indicates an ability of occult cancer cells to survive in a non- or slow-proliferating state, retaining a potential for progression and proliferation at a later time point. More...
30 Oct 2018
Image: A photomicrograph from a prostate biopsy of prostatic adenocarcinoma, conventional (acinar) type, the most common form of prostate cancer (Photo courtesy of Nephron).

Fatal Prostate Cancer Differentiated from Manageable Cancer

Human prostate cancers display numerous DNA methylation changes compared to normal tissue samples. However, definitive identification of features related to the cells’ malignant status has been compromised by the predominance of cells with luminal features in prostate cancers. More...
29 Oct 2018
Image: The MAGPIX compact multiplexing unit performs up to 50 different tests in a single reaction volume and reads a 96-well-plate in just 60 minutes (Photo courtesy of Luminex).

High-Risk HPV Evaluated for Invasive Cervical Cancer

Cervical cancer is a major cause of morbidity and mortality in women worldwide and the role of high-risk human papillomavirus (hrHPV) in the development of invasive cervical cancer (ICC) is well established. More...
29 Oct 2018
Image: A blood smear showing various leukocytes used to assess the complete white blood cell count by microscopy (Photo courtesy of the University of Minnesota).

Prognostic Value of Blood Cell Counts Investigated

The prognosis and treatment of gastric cancer patients after radical gastrectomy mainly depends on classification of malignant tumors (TNM) stage system. However, the prognosis of gastric cancer patients could be various even with the same tumor stage. More...
29 Oct 2018
Image: The NanoDrop 2000 Spectrophotometer used to quantify and assess purity of DNA, RNA, and Proteins (Photo courtesy of Thermo Fisher Scientific).

CD MicroRNA Marks Subtypes with Differing Outcomes

Crohn’s disease (CD), one of the primary inflammatory bowel diseases (IBD), is a chronic inflammatory condition of the gastrointestinal tract resulting from an aberrant immune response to the enteric microbiota in a genetically susceptible host. More...
25 Oct 2018
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The Pathology channel details advances in the field of Surgical Pathology and all its subspecialties, including Cytopathology and its subspecialties.