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Pathology

Image: The circulating tumor cells (CTC)-iChip is composed of two separate microfluidic devices that house three different microfluidic components engineered for inline operations (Photo courtesy of Massachusetts General Hospital).

Digital CTC Assay Improves Liver Cancer Diagnosis

Liver cancer, including hepatocellular carcinoma (HCC), is the second highest cause of cancer death in the world. HCC is particularly prevalent in developing countries, where its incidence is driven by infection with the hepatitis B virus, which now affects more than 248 million individuals. More...
01 Feb 2017
Image: The free Prostate-Specific Antigen (PSA) / total PSA fraction is significantly diminished in men with prostate cancer since almost all of the PSA is bound. When the fraction is under 10%, the risk of prostate cancer is high. When it is above 25%, the elevation of PSA is probably related to benign hyperplasia (Photo courtesy of Dianon Pathology).

Rapid Method Determines Free and Total PSA in Serum

Prostate-Specific Antigen (PSA) is a protein produced by prostate gland cells, circulates through the body in two ways: either bound to other proteins or on its own. PSA traveling alone is called free PSA. The free-PSA test measures the percentage of unbound PSA; the PSA test measures the total of both free and bound PSA. More...
01 Feb 2017
Image: A histopathology of prostate cancer – The presence of luminal comedo necrosis in a cancer gland space is sufficient to diagnose Gleason grade 5 (Photo courtesy of Kenneth Iczkowski, MD).

Cancer Biomarkers Identify Candidates for Aggressive Treatment

Prostate cancer (PC) is the second leading cause of male cancer death in the USA with an estimated 26,000 deaths in 2016. Two-thirds of all PC deaths observed in the US are men with localized disease who developed metastasis. More...
26 Jan 2017
Image: Impacted cerumen (green-yellow in diagram) can completely obstruct the ear canal (Photo courtesy of Schwartz SR et al / American Academy of Otolaryngology – Head and Neck Surgery Foundation).

Experts Update Clinical Practices Guideline for Earwax Impaction

An new guideline from the American Academy of Otolaryngology – Head and Neck Surgery Foundation provides updated evidence-based recommended practices for diagnosis and treatment of cerumen impaction as well as for patient education on healthy ear care. More...
24 Jan 2017
Image: A diagram of circulating tumor cells in a blood sample that can be analyzed for DNA (Photo courtesy of CellMax Life).

Liquid Biopsy Assists with Tumor Treatment Response Monitoring

Non-invasive “liquid biopsies” such as blood tests are growing in use as they help overcome problems of inherent tumor heterogeneity of cancer cells, while providing previously unavailable insight into drug-resistance. They are essential in tracking and monitoring an otherwise intractable disease. More...
19 Jan 2017
Image: The 2200 TapeStation instrument (Photo courtesy of Agilent Technologies).

Vaginal Microbes Denote Early Detection of Endometrial Cancer

Endometrial cancer triggers remain elusive, but given the typical inflammatory profile in these cases, microbes in the uterine environment are suspected to play a role in the development of this disease. More...
19 Jan 2017
Image: The NextSeq 500 Series desktop sequencing system (Photo courtesy of Illumina).

Mutational Profile of Metastatic Breast Cancers Analyzed

Breast cancer often results in poor outcomes after it has metastasized to distant organs, but, while primary breast tumors have been extensively characterized at the molecular level, metastatic lesions are poorly understood. More...
18 Jan 2017
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The Pathology channel details advances in the field of Surgical Pathology and all its subspecialties, including Cytopathology and its subspecialties.