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Pathology

Image: Droplet digital PCR measures tumor load by non-invasive means. The technique takes advantage of the cell-free DNA circulating in blood, which is found in higher concentration in cancer patients (Photo courtesy of Christof Winter, MD, PhD).

Liquid Biopsy Potential Tested with ddPCR Technology

Droplet digital polymerase chain reaction (ddPCR) technology has been used to investigate the benefits of tracking drug-resistance mutations in the circulating DNA (ctDNA) of patients with hormone receptor-positive (HR+) metastatic breast cancer. More...
10 Apr 2019
Image: A photomicrograph of a pleural fluid cytopathology specimen showing mesothelioma (Photo courtesy of Nephron).

Malignant Pleural Mesothelioma Personalized by ctDNA Profiling

Malignant pleural mesothelioma (MPM) is an aggressive tumor associated with exposure to asbestos and is rising in incidence worldwide. More...
09 Apr 2019
Image: The UltraClean PCR cleanup kit (Photo courtesy of MO BIO Laboratories).

Fecal Microbes Used to Diagnose Liver Cirrhosis

Nonalcoholic fatty liver disease (NAFLD) is the most prevalent cause of chronic liver disease worldwide, and yet remains largely underdiagnosed even in individuals with advanced stage of the disease. More...
09 Apr 2019
Image: Human IL-6 Luminex Performance ELISA Assay (Photo courtesy of R&D Systems).

Haptoglobin Expression Linked to Newborn Outcomes

Proteomics has facilitated discovery of biomarkers to better understand the pathophysiology of early-onset neonatal sepsis with the goal of identifying as early as possible the newborns more likely to die or develop significant morbidity. More...
09 Apr 2019
Image: The BD-FACS AriaII cytometer (Photo courtesy of the University of California, Merced).

EBV-DNA Measured in Nasopharyngeal Carcinoma Patients

Nasopharyngeal carcinoma (NPC) is one of the head and neck epithelial cancers and is a serious threat to human health. According to the latest statistics, about 80% of patients with NPC were observed in Asia, especially in Southeast Asia and south China. More...
08 Apr 2019
Image: A scanning electron micrograph (SEM) of lung cancer cells (Photo courtesy of Cancer Research UK).

Immune Relationship to Lung Tumor Evolution Characterized

Non-small-cell lung carcinoma (NSCLC) is any type of epithelial lung cancer other than small cell lung carcinoma (SCLC). NSCLC accounts for about 85% of all lung cancers. As a class, NSCLCs are relatively insensitive to chemotherapy, compared to small cell carcinoma. More...
04 Apr 2019
Image: A diagram of evolutionary trajectories of IDH-WT glioblastomas revealing a common path of early tumorigenesis instigated years ahead of initial diagnosis (Photo courtesy of German Cancer Research Center).

Glioblastoma Driver Mutations Appear Long Before Diagnosis

Glioblastomas are the most common high-grade (cancerous) primary brain tumor in adults. They can also occur, rarely, in children. Glioblastomas belong to a group of brain tumors known as gliomas, as they grow from a type of brain cell called a glial cell. More...
03 Apr 2019
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The Pathology channel details advances in the field of Surgical Pathology and all its subspecialties, including Cytopathology and its subspecialties.
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