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Pathology

Image: An immunohistochemical staining IL-17A expression in (A) M. mycetomatis, and (B) S. somaliensis. IL-17A staining was seen as a brown cytoplasmic staining in cells (Photo courtesy of University of Khartoum).

Immune Molecules Expressed Inside Mycetoma Lesions

Mycetoma is a persistent, progressive granulomatous inflammatory disease caused either by fungi or by bacteria. Characteristic of this disease is that the causative agents organize themselves in macroscopic structures called grains. These grains are surrounded by a massive inflammatory reaction. More...
24 Jul 2019
Image: The MiSeq System: access focused applications such as targeted resequencing, metagenomics, small genome sequencing, targeted gene expression profiling (Photo courtesy of Illumina).

Next-Generation Sequencing Identifies Monogenic Diabetes

Monogenic diabetes is seen mainly in maturity onset diabetes of the young (MODY), and accounts for 1%–2% of all diabetes cases. In adults, monogenic diabetes is difficult to distinguish from common diabetes causes. More...
23 Jul 2019
Image: EndoPredict is a next-generation breast cancer recurrence test that integrates tumor biology and pathology to accurately predict early and late (5-15 years) recurrence with an individualized absolute chemotherapy benefit (Photo courtesy of Myriad Genetics).

Multigene Expression Profiling Assays Compared for Cancer

A cost-effectiveness analysis recently published has added another factor to the ongoing competition and debate between various companies offering genomic breast cancer recurrence assays. More...
19 Jul 2019
Image: Ultra-Sensitive TP53 sequencing for cancer detection reveals progressive clonal selection in normal tissue over a century of human lifespan (Photo courtesy of University of Washington).

Low-Frequency TP53 Gene Mutations Also Found in Healthy Women

Worldwide, more than 250,000 new cases of ovarian cancer are diagnosed each year, and two-thirds of these women die from the disease. This high mortality is largely due to the high frequency of metastasis before diagnosis and a lack of effective screening and early detection methods. More...
19 Jul 2019
Image: The Epi ProColon screening test is a blood-based colorectal cancer screening test is an in vitro polymerase chain reaction assay for the qualitative detection of Septin9 gene methylation in DNA isolated from the patient’s plasma (Photo courtesy of Epigenomics).

Blood Test Complements Colonoscopy for Lynch Syndrome Patients

Lynch syndrome (LS) subjects are genetically predisposed to a high risk for colorectal cancer (CRC) and regular colonoscopy is currently the only CRC screening option recommended for these subjects, although compliance is suboptimal. More...
16 Jul 2019
Image: Research shows fibromyalgia patients may have a distinct composition of gut microbiome species (Photo courtesy of Christopher Bergland).

Microbiome Composition Altered in Fibromyalgia Patients

Fibromyalgia (FM) is a prevalent syndrome, characterized by chronic widespread pain, fatigue and impaired sleep, that is challenging to diagnose and difficult to treat. FM is a long-term condition that affects 2% to 4% of the USA population, which equates to about 6 to 12 million people. More...
11 Jul 2019
Image: A diagram of how the X-Linked DDX3X RNA helicase dictates translation reprogramming and metastasis in melanoma (Photo courtesy of Lund University).

Protein Linked to Aggressive Skin Cancer

Almost 300,000 people worldwide develop malignant melanoma each year. The disease is the most serious form of skin cancer and the number of cases reported annually is increasing, making skin cancer one of Sweden's most common forms of cancer. More...
10 Jul 2019
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The Pathology channel details advances in the field of Surgical Pathology and all its subspecialties, including Cytopathology and its subspecialties.