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Pathology

Image: Ultra-Sensitive TP53 sequencing for cancer detection reveals progressive clonal selection in normal tissue over a century of human lifespan (Photo courtesy of University of Washington).

Low-Frequency TP53 Gene Mutations Also Found in Healthy Women

Worldwide, more than 250,000 new cases of ovarian cancer are diagnosed each year, and two-thirds of these women die from the disease. This high mortality is largely due to the high frequency of metastasis before diagnosis and a lack of effective screening and early detection methods. More...
19 Jul 2019
Image: The Epi ProColon screening test is a blood-based colorectal cancer screening test is an in vitro polymerase chain reaction assay for the qualitative detection of Septin9 gene methylation in DNA isolated from the patient’s plasma (Photo courtesy of Epigenomics).

Blood Test Complements Colonoscopy for Lynch Syndrome Patients

Lynch syndrome (LS) subjects are genetically predisposed to a high risk for colorectal cancer (CRC) and regular colonoscopy is currently the only CRC screening option recommended for these subjects, although compliance is suboptimal. More...
16 Jul 2019
Image: Research shows fibromyalgia patients may have a distinct composition of gut microbiome species (Photo courtesy of Christopher Bergland).

Microbiome Composition Altered in Fibromyalgia Patients

Fibromyalgia (FM) is a prevalent syndrome, characterized by chronic widespread pain, fatigue and impaired sleep, that is challenging to diagnose and difficult to treat. FM is a long-term condition that affects 2% to 4% of the USA population, which equates to about 6 to 12 million people. More...
11 Jul 2019
Image: A diagram of how the X-Linked DDX3X RNA helicase dictates translation reprogramming and metastasis in melanoma (Photo courtesy of Lund University).

Protein Linked to Aggressive Skin Cancer

Almost 300,000 people worldwide develop malignant melanoma each year. The disease is the most serious form of skin cancer and the number of cases reported annually is increasing, making skin cancer one of Sweden's most common forms of cancer. More...
10 Jul 2019
Image: A histological preparation from a patient with invasive lobular carcinoma, demonstrating a predominantly lobular growth pattern (Photo courtesy of KGH).

Test Determines If Cancer Patients Require Chemotherapy

Invasive lobular carcinoma (ILC) is the most common special type of breast cancer, and is characterized by functional loss of E-cadherin, resulting in cellular adhesion defects. ILC typically present as estrogen receptor positive, grade 2 breast cancers, with a good short-term prognosis. More...
09 Jul 2019
Image: A histopathology of lymph node with metastatic adenocarcinoma of the colon (Photo courtesy of Dr. Ed Uthman M.D).

Metastases May Form Early in Development of Colorectal Cancer

Colorectal cancer (CRC), also known as bowel cancer and colon cancer, is the development of cancer from the colon or rectum (parts of the large intestine). Signs and symptoms may include blood in the stool, a change in bowel movements, weight loss, and feeling tired all the time. More...
04 Jul 2019
Image: (A and B) Photomicrographs of the layers of the device; (C) the mold ready for casting and (D) the chip mounted on a slide (Photo courtesy of San Diego State University).

Microfluidic Device Isolates Circulating Tumor Cell Clusters

The three main challenges of cancer treatment are metastases, recurrence, and acquired therapy resistance. These challenges have been closely linked to circulating cancer cell clusters. More...
03 Jul 2019
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The Pathology channel details advances in the field of Surgical Pathology and all its subspecialties, including Cytopathology and its subspecialties.
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