Pathology
Single-Cell Transcriptome Links Gut Development, Pediatric Crohn's Disease
Development of the human intestine is a highly complex process that requires synergy between a wide range of cell types. Importantly, environmentally triggered alterations in early development have been implicated in a range of immune-mediated pathologies, including inflammatory bowel diseases (IBD). More...29 Dec 2020
Rare Genetic Variants Can Contribute to Ischemic Heart Failure
Heart failure affects about 40 million people globally, and most cases are due to ischemic heart disease, hypertension, or cardiomyopathies. Cardiomyopathies have been traced to rare variants in genes that encode sarcomere or cytoskeletal proteins, channels, or desmosomes, while genome-wide association studies have underscored common variants linked to heart failure. More...29 Dec 2020
Distinct Mutation Patterns Identified in Appendiceal Cancer
The incidence of appendiceal cancer (AC) is rising, particularly among individuals younger than 50 years (early-onset AC), with unexplained etiologies. The unique spectrum of somatic cancer gene variations among patients with early-onset AC is largely undetermined. More...24 Dec 2020
Circulating Tumor Cell Dynamics Predicts Cancer Prognosis
Metastatic breast cancer, also called stage IV breast cancer, means the cancer has traveled through the bloodstream to create tumors in the liver, lungs, brain, bones and/or other parts of the body. Approximately 20% to 30% of women with early stage breast cancer go on to develop metastatic disease. More...23 Dec 2020
Flow Cytometry Employed in Diagnosing Male Urethritis
According to the established guidelines, diagnosis of non-gonococcal urethritis should be confirmed by demonstrating polymorphonuclear leukocytes from the anterior urethra using a Gram-stained (GSS) or methylene blue-stained urethral smear. More...17 Dec 2020
Gene Expression Signature Traces Nonalcoholic Fatty Liver Disease Progression
Nonalcoholic fatty liver disease (NAFLD) is a common condition marked by the accumulation of triglycerides and other lipids in the liver and is associated with metabolic syndrome, type 2 diabetes, hypertension, and dyslipidemia. More...16 Dec 2020
Triple FIT Surpasses Single Sigmoidoscopy in CRC Screening
Colorectal cancer (CRC) almost always develops from precancerous polyps (abnormal growths) in the colon or rectum. Screening tests can find precancerous polyps, so that they can be removed before they turn into cancer. Screening tests can also find colorectal cancer early, when treatment works best. More...10 Dec 2020
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Comprehensive Molecular Profiling Matches Pediatric Patients to Therapies
Urine-Based Liquid Biopsy Test Detects Urothelial Carcinoma
Breath Test Developed for Head and Neck Cancer Diagnosis
Lymphocytic Infiltration Explored as Biomarker for Stable Colorectal Tumors
Hematological Biomarkers Predict Prognosis in Hepatocellular Carcinoma
HPV, p16 Offers Different Prognostic Clues in Oropharyngeal Cancer
Serum Thyroglobulin Assays Compared for Differentiated Thyroid Carcinoma
Epigenetic Markers Predict Type 2 Diabetes Patients Response to Metformin
New Diagnosed Anemia Linked to Crohn’s Disease Risk
The Pathology channel details advances in the field of Surgical Pathology and all its subspecialties, including Cytopathology and its subspecialties.