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Immunology

Image: The enzyme immunoassay for quantitative determination of testosterone concentration in human serum (Photo courtesy of Pointe Scientific).

Testosterone Reference Ranges Vary Widely in Medical Laboratories

The evaluation and management of male hypogonadism should be based on symptoms and on serum testosterone levels and diagnostically this relies on accurate testing and reference values. This circumstance not only affects how clinicians determine treatment, but also whether insurers approve therapy for men with low testosterone levels. More...
30 Jun 2016
Image: The NuQ biomarker assays capture and identify nucleosomes circulating in the blood of cancer patients (Photo courtesy of VolitionRx).

Circulating Cell-Free Nucleosomes Biomarkers Confirmed for Cancer Blood Tests

Studies have shown substantially improved overall survival among individuals screened for colorectal cancer (CRC), which is explained by diagnosis of early stages and prevention of CRC by endoscopic removal of precancerous lesions. More...
30 Jun 2016
Image: A histopathology of polymyositis showing endomysial mononuclear inflammatory infiltrate and muscle fiber necrosis (Photo courtesy of Ramesh Pappu, MD, DPH).

Testing Methods Compared for Myositis Specific Autoantibodies

The performance of a line blot assay for the identification of autoantibodies in sera of patients affected by myositis has been compared with immunoprecipitation (IP) as gold standard. More...
28 Jun 2016
Image: Lung tissue with lesions caused by pulmonary hypertension (Photo courtesy of Bulent Celasun, MD / Wikimedia).

Noninvasive Test May Predict Severity of Pulmonary Arterial Hypertension

Researchers report that rising blood levels of the hematoma derived growth factor (HDGF) protein are linked to increasing severity of pulmonary arterial hypertension (PAH). Their results, using a newly developed ELISA test, showed a dose-response critical for demonstrating preliminary, proof-of-principle research, and could lead to a noninvasive, more specific test for PAH. More...
28 Jun 2016
Image: A photomicrograph of sickle-shape red blood cells from a patient with sickle cell disease (Photo courtesy of the CDC).

Novel Approach Could Make Bone Marrow Transplants Safer

Treatment has been developed for bone marrow, via blood stem cell, transplantation safer and, as a result, more widely available to the millions of people living with blood disorders like sickle cell anemia, thalassemia, and acquired immune deficiency syndrome (AIDS). More...
23 Jun 2016
Image: The Agilent Bioanalyzer microfluidics-based platform (Photo courtesy of Agilent Technologies).

Blood Test Predicts Personalized Depression Treatment

A blood test has been developed that accurately and reliably predicts whether depressed patients will respond to common antidepressants, which could herald a new era of personalized treatment for people with depression. More...
22 Jun 2016
Image: The ImmunoSEQ kit for analyzing T- and B-cells (Photo courtesy of Adaptive Biotechnologies).

T-Cell Receptor Sequencing Reveals Novel Biomarkers For Ovarian Cancer

Deep T-cell receptor (TCR) sequencing has been used to evaluate the clonal composition of tumor-infiltrating lymphocytes and identify novel prognostic biomarkers in ovarian cancer. More...
22 Jun 2016
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The Immunology channel of LabMedica deals with diagnostic techniques and immuonassays such as ELISA, pregnancy tests, immunoblotting, immunohistochemical staining, serology, and associated hardware.
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