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Immunology

Image: Immunohistochemical detection of human intestinal spirochetosis with signs of invasion (Photo courtesy of the US National Institute of Health).

Anti-Treponema Immunohistochemistry Cross-Reactivity Reported with Non-Treponema Spirochetes

Syphilis has different histopathologic presentations, and it can mimic a significant number of entities while human intestinal spirochetosis is characterized by the presence of a layer of spirochetes adherent to the apical epithelial surface of the colorectal mucosa. More...
12 Oct 2016
Image: The compact EUROBlotMaster processor for immunoblot strips (Photo courtesy of Euroimmun AG).

Increased Serum Cytokine Concentrations Reported in Guillain-Barré Syndrome

Guillain-Barré syndrome (GBS) is an acquired demyelinating peripheral neuropathy and it has been shown that macrophage activation contribute to the pathogenesis of GBS. Therefore macrophage-mediated factors could be the potential markers for disease diagnosis and status of GBS. More...
05 Oct 2016
Image: Average scores for tumor cells in study comparing results of four available PD-L1 assays used by pathologists in assessing non-small cell lung cancer tumors (Image courtesy of David Rimm Laboratory / Yale Cancer Center).

Effectiveness of PD-L1 Tests Compared for Non-Small-Cell Lung Cancer

In a recent study, clinical researchers compared performance of the 4 available assays for the tumor-promoting protein PD-L1 as a biomarker for assessing non-small cell lung cancer (NSCLC). They found that one assay failed to result in comparable levels of PD-L1, while the three other assays resulted in comparable levels. More...
04 Oct 2016
Image: The T-SPOT.TB Interferon-gamma release assay for tuberculosis screening (Photo courtesy of Oxford Immunotec Global).

Screening for Latent Tuberculosis Infection Recommended

Tuberculosis remains an important preventable disease, including active tuberculosis infection, which may be infectious and latent infection (LTBI), which is asymptomatic and not infectious, but can later reactivate and progress to active disease. More...
29 Sep 2016
Image: The C Scanner high-resolution microarray scanner (Photo courtesy of Agilent Technologies).

Method Developed Predicts Disease Activity in Multiple Sclerosis

Multiple sclerosis, or MS, is an inflammatory disease of the central nervous system that mainly affects young adults and it is not currently possible to know which individuals with multiple sclerosis, a life-long condition, risk developing severe disease. More...
28 Sep 2016
Image: The BS-380 automatic biochemistry analyzer (Photo courtesy of Mindray).

Novel Turbidimetric Immunoassay Evaluated for Fecal Calprotectin

Calprotectin is a multifunctional protein that plays an important role in the diagnosis and follow-up of inflammatory bowel disease and high levels of calprotectin in stool samples are associated with inflammation of the intestinal tract. More...
28 Sep 2016
Image: The cobas h 232 POC system, designed for use with the Elecsys high sensitivity cardiac troponin (hs-cTnT) assay (Photo courtesy of Roche).

Optimal Rule-Out Biomarker Strategy Developed for Acute MI

Assessment of patients presenting to the Emergency Department (ED) with symptoms suggestive of acute coronary syndrome (ACS) represents a major clinical challenge, since the majority of patients do not have a final diagnosis of acute myocardial infarction (AMI). More...
27 Sep 2016
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The Immunology channel of LabMedica deals with diagnostic techniques and immuonassays such as ELISA, pregnancy tests, immunoblotting, immunohistochemical staining, serology, and associated hardware.
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