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Hematology

Image: The Bio-Flash Rapid-Response Chemiluminescent Analyzer (Photo courtesy of Inova Diagnostics).

Immunoassay Systems Evaluated for Detection of Antiphospholipid Antibodies

Antiphospholipid syndrome or antiphospholipid antibody syndrome, or also Hughes syndrome, is an autoimmune, hypercoagulable state caused by antiphospholipid antibodies.  More...
28 Mar 2016
Image: Blood smear showing a segmented neutrophil and a mature lymphocyte with a single large nucleus (Photo courtesy of the University of Utah Medical School).

Early Stage Breast Cancer Recurrence Linked to High Leukocyte Ratio

A high ratio of two types of immune system cell is linked to an increased risk of disease recurrence after a diagnosis of early stage breast cancer and the findings might guide future treatment and monitoring strategies, if prospective studies confirm the link.  More...
23 Mar 2016
Image: The Videssa Breast diagnostic test provides accurate early detection and typing of breast cancers by combining anatomical evidence from imaging with evidence from its proteomics test for proteins released into the blood system by cancer tumors (Image courtesy of Provista Diagnostics).

Age Should Be Considered in Developing Diagnostic Assays

In a new study on breast cancer, blood test results have demonstrated age-related differences in Tumor-Associated Antibodies, showing for the first time age-related differences that should be taken into consideration when developing diagnostic tests.  More...
23 Mar 2016
Image: Laser scanning confocal microscopy of clots constructed from adult fibrinogen (A), neonatal fibrinogen (B), or a mixture of the two (C). Scale bar= 20 μm (Photo courtesy of North Carolina State University).

Fibrin Network Changes in Neonates After Cardiopulmonary Bypass

Quantitative and qualitative differences in the hemostatic systems exist between neonates and adults, including the presence of “fetal” fibrinogen, a qualitatively dysfunctional form of fibrinogen that exists until one year of age.  More...
22 Mar 2016
Image: Histopathology comparing normal bowel at the left, to a bowel involved by necrotizing enterocolitis (NEC) at the right showing hemorrhagic necrosis, beginning in the mucosa and extending to involve the muscular wall, with the potential for perforation (Photo courtesy of the University of Utah School of Medicine).

Severe Anemia Associated with Increased Risk of Necrotizing Enterocolitis

Necrotizing enterocolitis an acute, life-threatening, inflammatory disease occurring in the intestines of premature infants, is a leading cause of mortality among preterm infants with case-fatality rates of 20% to 30% yet the origin and development of NEC remains unclear.  More...
16 Mar 2016
Image: The “SCD biochip” microfluidic system for probing red blood cell (RBC) dynamic deformability and adhesion from whole sickle cell disease (SCD) patient blood samples (Photo courtesy of Case Western Reserve University).

Novel Device Measures Stiffness and Stickiness in Erythrocytes

In sickle cell disease, hemoglobin molecules polymerize intracellularly and lead to a cascade of events resulting in decreased deformability and increased adhesion of red blood cells. Decreased deformability and increased adhesion of sickle RBCs lead to blood vessel occlusion, known as vaso-occlusion, in SCD patients.   More...
13 Mar 2016
Image: Photomicrograph of blood smear devoid of platelets from a patient with thrombocytopenia (Photo courtesy of the Icahn School of Medicine at Mount Sinai).

Higher Histone Levels Associated with Thrombocytopenia

Thrombocytopenia is observed in approximately 30% to 40% of patients in the intensive care unit concomitant with poor outcomes and an association with histones has been examined.   More...
09 Mar 2016
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The Hematology channel at LabMedica covers the all aspect of plasma, coagulation, transfusion medicine, and blood banking, as well as related lab tools and techniques.
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