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Molecular Diagnostics

Image: A scanning electron micrograph (SEM) of a human neutrophil ingesting methicillin resistant Staphylococcus aureus (MRSA) (Photo courtesy of US National Institute of Allergy and Infectious Diseases).

DNA Sequencing of MRSA Predicts Patient Survival

Methicillin-resistant Staphylococcus aureus (MRSA) is a bacterium that has become resistant to most types of antibiotics, and up to 20% of patients with invasive infections die. Although S. aureus is a common bacterium that lives on the skin, if it gets inside the body through a cut it can cause septicemia. More...
23 Aug 2017
Image: A histologic section of a colonic adenoma containing invasive carcinoma (Photo courtesy of Dr. Mauro Risio).

New Molecular Test Identifies Colorectal Cancer

Colorectal cancer is one of the leading causes of cancer-related deaths worldwide, with more than 600,000 deaths each year. Among individuals undergoing treatment for the disease, recurrence occurs in 30% to 50% of all cases. The majority of these cases present in the first two to three years following initial diagnosis and treatment. More...
23 Aug 2017
Image: A glioblastoma induced by the new gene-editing and screening technology (Photo courtesy Chen Lab, Yale University).

CRISPR Technology Identifies Cancer-Causing Genes

Researchers have identified specific gene combinations that can cause the brain cancer glioblastoma, using their newly developed modified CRISPR technology that can also pinpoint triggers and primary drivers of other types cancers. Thus the new technology could help improve diagnostics, as well as in finding more specific targets for developing more effective drugs. More...
22 Aug 2017

Liquid Biopsy Approach Inspired by Swarm Behavior

Researchers have designed an algorithm for blood sample analysis where, rather than testing for evidence of cancer DNA or protein biomarkers, they test for tumor cell RNA absorbed by circulating platelets – i.e. thrombocytes. In a new study, they designed the test to diagnose non-small cell lung cancers (NSCLCs), which make up the majority of lung cancer cases, and achieved ~90% accuracy on a validation control group. More...
21 Aug 2017
Image: A bioplasmonic paper-based device (BPD) for the detection of Zika virus (ZIKV) infection, via quantification of serum anti-ZIKV-nonstructural protein 1 (NS1) IgG and IgM (Photo courtesy of James Byard).

Biosensor Device Developed for Zika Diagnosis

A novel plasmonic biosensor-based detection system was developed that can diagnose recent or current Zika virus (ZIKV) infection in 15 minutes or less. More...
21 Aug 2017
Image: The Luminex 200 multiplex analyzer (Photo courtesy of Luminex Corporation).

Cytokine Concentration Linked to Chronic Fatigue Syndrome

More than one million people in the USA suffer from chronic fatigue syndrome, also known as myalgic encephomyelitis and designated by the acronym ME/CFS. It is a disease with no known cure or even reliably effective treatments. More...
16 Aug 2017
Image: A histopathology of adrenal pheochromocytoma from an adrenectomy specimen showing the characteristic stippled (finely granular) chromatin (Photo courtesy of Nephron).

Mutations Related to Hereditary Neuroendocrine Tumors

Pheochromocytomas and paragangliomas are rare neuroendocrine tumors with a strong hereditary component and half the genes whose alterations confer hereditary susceptibility to develop this condition code for enzymes involved in the Krebs cycle. More...
16 Aug 2017
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Genetic Testing channel of LabMedica brings the latest in molecular genetics, cytogenetics, and epigenetics, and methods from PCR to FISH, and more.