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Molecular Diagnostics

Image: The Applied Biosystems Step One Real-Time PCR (Photo courtesy of Thermo Fisher Scientific).

Circulating Blood Markers Identified for Abnormal Heart Rhythms

The irregular heart rhythm atrial fibrillation (AF) increases the risk of stroke and heart failure, but is often undiagnosed because of a lack of symptoms. AF increases the risk of developing strokes, heart failure, and even dementia. More...
29 Mar 2018
Image: The 5500xl SOLiD genetic analyzer (Photo courtesy of Life Technologies).

Synesthesia Family Exomes Lead to Rare Gene Variants

Synesthesia is a neurological phenomenon that causes unusual links between sensory experiences, and its molecular basis is completely unknown. Synesthesia is a perceptual phenomenon in which stimulation of one sensory or cognitive pathway leads to automatic, involuntary experiences in a second sensory or cognitive pathway. More...
22 Mar 2018
Image: The NextSeq 500 benchtop sequencer delivers on-demand exome, transcriptome and whole-genome sequencing (Photo courtesy of Illumina).

Distinct Epigenetic Features Found in Alzheimer's Brains

Aging is the strongest risk factor for Alzheimer’s disease (AD), although the underlying mechanisms remain unclear though AD tends to coincide with certain chromatin shifts in the aging brain. More...
21 Mar 2018
Image: The bacterium Salmonella enterica serovar Typhi in Pakistan have developed greater drug resistance by acquiring a DNA plasmid encoding further antibiotic resistance genes from another bacteria (Photo courtesy of Dave Goulding, Wellcome Sanger Institute).

Typhoid Fever Bacteria Sequencing Reveals Drug Resistance Genes

Antibiotic resistance is a major problem in Salmonella enterica serovar Typhi, the causative agent of typhoid. Multidrug-resistant (MDR) isolates are prevalent in parts of Asia and Africa and are often associated with the dominant H58 haplotype. More...
21 Mar 2018
Image: Extracellular vesicles (red) released from a patient’s tumor and captured on the surfaces of the EVHB-Chip (Photo courtesy of Professor Shannon Stott, PhD).

Microfluidic Device Captures Tumor-Specific Extracellular Vesicles

A microfluidic device has been developed that can capture glioblastoma-derived extracellular vesicles, with high specificity, using very small blood samples, which would be useful for pediatric patients. More...
21 Mar 2018
Image: Postmortem tissue sample from an Alzheimer’s disease (AD) patient brain reveals AD pathology including amyloid-beta plaques and Tau tangles (Photo courtesy of Dr. Dale Bredesen).

Parent Age May Help Predict AD Biomarker Levels

Alzheimer disease (AD) develops during several decades and presymptomatic individuals might be the best candidates for clinical trials, but their identification is challenging because they have no symptoms. More...
14 Mar 2018
Image: The QX200 AutoDG automated droplet generator, part of the Bio-Rad QX200 PCR System (Photo courtesy of Compass Design).

Blood Test Predicts Patient Response to Chemotherapy

Early changes in circulating tumor DNA (ctDNA) level may provide early response prediction, but the impact of tumor heterogeneity is unknown. More...
14 Mar 2018
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Genetic Testing channel of LabMedica brings the latest in molecular genetics, cytogenetics, and epigenetics, and methods from PCR to FISH, and more.
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