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Molecular Diagnostics

Image: A histology slide stained with hematoxylin and eosin (H&E) and the corresponding three-dimensional cancer density map, which facilitate the measurement of spatial proximity to cancer for every single lymphocyte in the image (Photo courtesy of The Institute of Cancer Research).

Gene Expression Correlates with Lymphocyte Infiltration in Breast Cancer

Lymphocytic infiltration is associated with a favorable prognosis and predicts response to chemotherapy in many cancer types, including the aggressive triple-negative breast cancer.  More...
30 Dec 2014
Image: Micrograph of a pleural fluid cytopathology specimen showing mesothelioma (Photo courtesy of Wikimedia Commons).

Mutations in Rare Asbestos-Caused Cancer Identified by Targeted Next-Generation Sequencing

Targeted next-generation sequencing, an advanced genomic analysis tool, was used to identify genes linked to the development of the rare cancer malignant pleural mesothelioma.  More...
29 Dec 2014
Image: Location of the Breast cancer 1, early onset (BRCA1) gene on chromosome 17 (Photo courtesy of Armin Kübelbeck).

Genetic Tests for Breast Cancer Detect More Mutations

A new study has demonstrated the ability of a commercial Hereditary Cancer test to detect 105% more mutations in cancer causing genes than conventional Breast Cancer testing alone.  More...
28 Dec 2014
Image: In meiosis, the chromosomes duplicate (during interphase) and homologous chromosomes exchange genetic information (chromosomal crossover) before a first division, called meiosis I. The daughter cells divide again in meiosis II, splitting up sister chromatids to form haploid gametes. Male and female gametes fuse during fertilization, creating a diploid cell with a complete set of paired chromosomes (Photo courtesy of the [US] National Institutes of Health).

Genome Analysis Shows Meiosis Gene Mutation Causes Primary Ovarian Insufficiency

A mutation in a gene linked to the process of meiosis was found in two sisters diagnosed with primary ovarian insufficiency, a syndrome that prevented them from reaching sexual maturity.   More...
28 Dec 2014
Image: The Xevo G2 quadrupole time-of-flight mass spectrometer (Q-TOFMS) (Photo courtesy of Waters Corporation).

Novel Biomarkers Identified for Incident Coronary Heart Disease

Metabolic profiling has identified circulating, novel lipid-derived molecules that are associated with future coronary heart disease events, which will enable early diagnosis of cardiovascular disease.   More...
24 Dec 2014
Image: The Oncotype specimen collection and transportation kit (Photo courtesy of Global Health Inc.).

Gene Assay Reduces Chemotherapy in Younger Breast Cancer Patients

A commercial gene assay has been used to help estimate the likelihood of recurrence in women with early-stage breast cancer and, thus, determine those who may or may not benefit from adjuvant chemotherapy.  More...
23 Dec 2014
Image: X-ray showing bamboo spine in a patient with ankylosing spondylitis (Photo courtesy of Steven Fruitsmaak).

Gene Variant Test Distinguishes Individuals with Ankylosing Spondylitis

Natural variations in an immune system enzyme that can leave individuals susceptible to the inflammatory rheumatic disease ankylosing spondylitis have been discovered.  More...
22 Dec 2014
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Genetic Testing channel of LabMedica brings the latest in molecular genetics, cytogenetics, and epigenetics, and methods from PCR to FISH, and more.
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