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Molecular Diagnostics

Image: A newly developed blood test detects pathogens carried by ticks such as this hard-bodied tick of the family Ixodidae (Photo courtesy of the CDC).

Blood Test Designed for Multiple Tick-borne Diseases

A novel blood test for the simultaneous diagnosis of multiple tick-borne diseases has been developed and shown to discriminate antibody responses to eight major tick-borne pathogens present in the United States. More...
27 Feb 2018
Image: A bone marrow biopsy showing plasma cells from a patient with multiple myeloma (Photo courtesy of the American Society of Clinical Oncology).

Multiple Myeloma Risk Genes Revealed

Two genes have been uncovered with apparent ties to inherited multiple myeloma risk, starting from analyses of several large American families that are frequently affected by the complex blood plasma cell cancer. More...
23 Feb 2018
Image: The Agilent 2100 bioanalyzer is a distinctive analysis tool capable of handling cells, proteins and nucleic acids on a single platform (Photo courtesy of Agilent Technologies).

Next-Gen Sequencing of CSF Diagnoses Neurobrucellosis

Brucellosis is the most common zoonotic infection in the world with more than 500,000 new cases are reported annually worldwide. It is a multisystem infection, with variable clinical presentations and brucellosis with nervous system involvement is known as Neurobrucellosis (NB). More...
21 Feb 2018
Image: The FLUOstar Omega multi-mode microplate reader with six detection modes (Photo courtesy of BMG Labtech).

Molecular Test Adapted for Parkinson’s and DLB

Parkinson’s disease (PD), multiple system atrophy (MSA), dementia with Lewy bodies (DLB) (or Lewy body dementia) are called α-synucleinopathies due to the abnormal accumulation of aggregates of a protein called α-synuclein (αSyn) in the brain. More...
20 Feb 2018
Image: The HiSeq X whole genome sequencing system (Photo courtesy of Illumina).

Genomic Sequencing Augments Diagnosis of Lymphoid Cancer

Lymphoid cancers include diffuse large B-cell lymphomas (DLBCL), follicular lymphoma (FL), and chronic lymphocytic leukemia (CLL). In recent years, several sequencing-based assays have been developed, but their clinical applicability and utility for patients with specific mutations still needs to be verified. More...
19 Feb 2018
Image: The Infinium methylation EPIC arrays for epigenome-wide association studies (Photo courtesy of Illumina).

Epigenetic Signatures Show Promise for Diagnosing Neurodevelopmental Disorders

Genome-wide DNA methylation signatures have been discovered for several neurodevelopmental Mendelian disorders, which clinically could complement existing molecular tests. More...
15 Feb 2018
Image: A histopathology of esophageal squamous cell carcinoma with keratin pearl formation (Photo courtesy of Dr. Dharam Ramnani, MD).

Esophageal Cancer GWAS Leads to Risk Variants

Genome-wide association studies have identified common variants associated with risk of esophageal squamous cell carcinoma; however, these common variants cannot explain all heritability of esophageal cancer. More...
15 Feb 2018
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