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Molecular Diagnostics

Image: Researchers introduced the first electrochemical CRISPR-based biosensor to help improve disease diagnostics (Photo courtesy of Richard Bruch, University of Freiburg)

CRISPR-based Electrochemical Biosensor Detects Disease-related MicroRNAs

 A microfluidic chip containing a CRISPR/Cas-based electrochemical biosensor has been introduced as a device for the rapid and precise analysis of the microRNAs involved in various disease states. More...
03 Dec 2019
Image:  False color SEM (scanning electron microscope) micrograph of a Leishmania promastigote. The cell body is shown in orange and the flagellum is in red (Photo courtesy of Wikimedia Commons)

Gene Panel Predicts Failure of Cutaneous Leishmaniasis Treatment

 Patients infected with the protozoan parasite Leishmania braziliensis develop chronic skin lesions that often fail to respond to treatment with anti-parasitic drugs. More...
03 Dec 2019
Image: Structure of the AP2A2 protein (Photo courtesy of Wikimedia Commons)

Genetic Locus with Unique Tandem Repeats Linked to Development of Late-onset Alzheimer’s Disease

 Researchers have discovered evidence of a novel genetic variation linked to the development of late-onset Alzheimer’s disease (AD). More...
02 Dec 2019
Image: The QuantStudio 7 Pro Real-Time PCR System is one of several platforms that the new ChromaCode multi-drug resistant (MDR) panel can be assayed (Photo courtesy of Thermo Fisher Scientific)

Multiplex Panel Debuts for Multi-Drug Resistant Infection Screening

 A multi-drug resistant (MDR) panel detects genetic signatures of resistance to specific antibiotics in pathogens that are commonly thought of as hospital acquired, and is designed to be used as a screening test for infection control and isolation of asymptomatic carriers. More...
28 Nov 2019
Image: Immunofluorescence image of microglial cells stained red with antibody. DNA shown in blue (Photo courtesy of Wikimedia Commons)

Non-coding Regions of the Genome in Microglia Linked to Alzheimer’s Disease Risk

 A recently published paper linked risk of developing Alzheimer’s disease (AD) to enhancers - non-coding DNA regions of the genome - that were present in microglia but not in other types of brain cells such as neurons or astrocytes. More...
28 Nov 2019
Image: Human sperm stained for semen quality testing in the clinical laboratory (Photo courtesy of Wikimedia Commons)

Epigenetic DNA Biomarkers Pinpoint Infertile Men and Predict Potential Success of Treatment

 A molecular analysis method was developed that identifies infertility in men through evaluation of genome wide alterations in sperm DNA methylation. More...
27 Nov 2019
Image: Small particle LDL has been associated with the progression of atherosclerosis and blockage the artery lumen, because it can carry cholesterol into smaller vessels. As atheroma enlarges, the arterial wall ruptures and releases blood clots that lead to narrowing of the artery (Photo courtesy of Wikimedia Commons)

LDL Subclasses Ratio Predicts Cardiovascular Disease Risk More Accurately than LDL-cholesterol Alone

 Measurement of low-density lipoprotein (LDL) cholesterol may a less effective way to predict risk of cardiovascular disease than is the further analysis of the relative proportions of LDL subclasses. More...
27 Nov 2019
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Genetic Testing channel of LabMedica brings the latest in molecular genetics, cytogenetics, and epigenetics, and methods from PCR to FISH, and more.
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