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Molecular Diagnostics

Image: Drumstick-shaped Clostridioides difficile bacilli as they appear in scanning electron microscopy (Photo courtesy of Kateryna Kon, PhD).

Fungus-Associated Bacteriome Associated with C. difficile Infection

Clostridioides difficile infection (CDI), the most common etiology of nosocomial infectious diarrhea, is caused by an intestinal dysbiosis that is virtually always attributable to antibiotics. This causes one of the most common hospital-acquired infections in the USA. More...
11 Sep 2019
Image: The Vanadis Core Cell-Free DNA analysis unit (Photo courtesy of PerkinElmer).

Novel Cell‐Free DNA Screening Assay Validated for Trisomies

Prenatal screening for trisomies 21, 18, and 13 is currently performed using multiple maternal serum and ultrasound markers. Clinical implementation studies of maternal plasma cell‐free (cf)-DNA testing have demonstrated a much higher sensitivity and specificity for these trisomies. More...
10 Sep 2019
Image: By measuring the methylation rate of microRNA, various cancer states can be detected (Photo courtesy of Osaka University).

Methylated MicroRNAs Prove Biomarkers for Early Detection of Cancer

A team of Japanese cancer researchers has shown that microRNA methylation was a more powerful indicator of early-stage pancreatic cancer than were established biomarkers, such as unmodified microRNAs. More...
09 Sep 2019
Image: A micrograph showing a mycosis (aspergillosis). The Aspergillus (which is spaghetti-like) is seen in the center and surrounded by inflammatory cells and necrotic debris (Photo courtesy of Wikimedia Commons).

New Official Guideline Summarizes Advances in Fungal Infections Diagnosis

An official clinical guideline on laboratory diagnosis of fungal infections in pulmonary and critical care medicine was released in a recent publication. More...
09 Sep 2019
Image: The top and front view of the three-dimensional structure of the pentameric nicotinic acetylcholine receptor, which is damaged or destroyed in myasthenia gravis (Photo courtesy of Wikimedia Commons).

Metabolites Pattern Distinguishes Myasthenia Gravis from RA Patients

A team of Canadian researchers used a pattern of 12 metabolites to distinguish myasthenia gravis patients from healthy individuals or from those with rheumatoid arthritis. More...
09 Sep 2019
Image: Risk stratification integrating genetic data for factor VIII inhibitor development in patients with severe hemophilia (Photo courtesy of Paris-Saclay University).

Genetics Affect Risk of Developing Factor VIII Inhibitors

For severe hemophilia A (HA) patients, the current standard of care includes regular prophylactic infusions of factor VIII (FVIII) products in order to prevent spontaneous bleeds or on demand infusions to treat bleeds. More...
06 Sep 2019
Image: The E.Z.N.A Stool Extraction Kit Isolates DNA from stool samples using spin columns (Photo courtesy of Omega Bio-tek).

Type 1 Diabetes Risk Reflected in Gut Microbiome

Type 1 diabetes mellitus (T1D) is an autoimmune disorder characterized by the destruction of insulin-producing ß-cells in the pancreas, resulting in a life-long dependence on exogenous insulin. T1D is an autoimmune condition that can develop at any age. More...
06 Sep 2019
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