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Molecular Diagnostics

Image: A pair of genes that influence risk for Alzheimer’s disease, MS4A4A and TREM2, affect immune cells in the brain. They influence Alzheimer’s risk by altering levels of TREM2, a protein (shown stained in red) that is believed to help microglia cells clear excessive amounts of the Alzheimer’s proteins amyloid and tau from the brain. The MS4A4A protein is shown stained in green (Photo courtesy of Fabia Filipello and Dennis Oakley, Washington University School of Medicine).

Brain Biomarkers Predict Alzheimer's Disease Risk and Progression

A cluster of genes has been identified that modulates the activity of TREM2 (Triggering receptor expressed on myeloid cells 2), a protein biomarker for risk and progression of Alzheimer’s disease (AD). More...
26 Aug 2019
Image: A newborn’s blood applied to a Guthrie Card for testing for various diseases including cytomegalovirus (Photo courtesy of NHS).

Congenital Cytomegalovirus Infection Diagnosed Via Dried Blood Spots

Cytomegalovirus is the leading cause of congenital infection (cCMV) affecting up to 0.8% of newborns in high-income countries and is the most common cause of non-genetic deafness in childhood. A wide range of diseases diagnosed either at birth or in childhood, has been correlated to cCMV infection. More...
21 Aug 2019
Image: The NextSeq 500 next-generation sequencer (Photo courtesy of Illumina).

Combination of Gene Mutations Linked to Endometrial Cancer

The endometrium is the dynamic inner layer of the uterus, composed of stroma and epithelial cells that undergo monthly proliferation, differentiation, and shedding throughout the menstrual cycle in reproductive age women. More...
21 Aug 2019
Image: A biopsy of small bowel showing celiac disease manifested by blunting of villi, crypt hypertrophy, and lymphocyte infiltration of crypts (Photo courtesy of Wikimedia Commons).

Interleukin-2 Suggested as Basis for Celiac Disease Diagnostic Test

A study designed to link changes in cytokine release following ingestion of gluten by individuals suffering from celiac disease found that interleukin-2 (IL-2) was the earliest and most prominent cytokine. More...
19 Aug 2019
Image: A high-magnification micrograph of diffuse proliferative lupus nephritis (Photo courtesy of Wikimedia Commons).

Urine Plasmin Identified as Strong Biomarker for Lupus Nephritis Diagnosis

Plasmin in the urine has been identified as the strongest predictor of estimated glomerular filtration rate (eGFR) and clinical renal disease in patients with lupus nephritis (LN). More...
19 Aug 2019
Image: A scanning electron micrograph of two rod-shaped bacteria called Klebsiella pneumoniae that are resistant to treatment with the “last resort” antibiotic drug called carbapenem. In this image, the mustard-colored bacteria are interacting with the green-colored human white blood cells (Photo courtesy of National Institute of Allergy and Infectious Diseases).

Carbapenem-Resistant K. Pneumoniae Driven by Nosocomial Spread

Public health interventions to control the current epidemic of carbapenem-resistant Klebsiella pneumoniae rely on a comprehensive understanding of its emergence and spread over a wide range of geographical scales. More...
15 Aug 2019
Image: The Mini8 Plus real time polymerase chain reaction (RT-PCR) thermocycler (Photo courtesy of Coyote Bioscience).

Direct Molecular Assay Developed for Zika Diagnosis

Zika virus (ZIKV), a mosquito-borne Flavivirus, is a positive single-stranded RNA virus with a nucleic acid length of about 10.7kb. This virus has been spreading rapidly and there have been large-scale outbreaks worldwide in recent years. ZIKV has drawn attention as it may cause severe symptoms while no specific medical treatment or vaccine is currently available. More...
14 Aug 2019
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T3 EIA 96 Kit


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