Molecular Diagnostics
Rare Genetic Variants Can Contribute to Ischemic Heart Failure
Heart failure affects about 40 million people globally, and most cases are due to ischemic heart disease, hypertension, or cardiomyopathies. Cardiomyopathies have been traced to rare variants in genes that encode sarcomere or cytoskeletal proteins, channels, or desmosomes, while genome-wide association studies have underscored common variants linked to heart failure. More...29 Dec 2020
Osteopontin Linked to Progressive Lung Scarring in Scleroderma Patients
Systemic sclerosis (SSc) is an autoimmune disease characterized by a distinct pathogenic triad of microvascular damage, dysregulation of innate and adaptive immunity, and fibrosis involving skin and many internal organs, such as the heart, kidney, and lungs. More...28 Dec 2020
Next-Generation Sequencing Detects Residual Disease in Acute Lymphoblastic Leukemia
The use of next-generation sequencing (NGS) to detect residual disease in acute lymphoblastic leukemia (ALL) patients after treatment can better gauge their risk of relapse and overall survival than multiparameter flow cytometry. More...24 Dec 2020
Distinct Mutation Patterns Identified in Appendiceal Cancer
The incidence of appendiceal cancer (AC) is rising, particularly among individuals younger than 50 years (early-onset AC), with unexplained etiologies. The unique spectrum of somatic cancer gene variations among patients with early-onset AC is largely undetermined. More...24 Dec 2020
Novel Classification System Identifies Prostate Cancer Patients Who May Benefit from Combined Immune and Radiation Therapies
A novel classification system is expected to aid in the subtyping of aggressive prostate cancers in patients who may benefit from combined immune and radiation therapies. More...22 Dec 2020
Plasma Levels of N-terminal Tau Fragments Predict Likelihood of Cognitive Decline in Elderly Individuals
A team of neurodegenerative disease researchers found that higher levels of N-terminal fragment of tau (NT1) in blood samples taken at the beginning of a survey of clinically normal elderly individuals were strongly associated with future risk of cognitive decline and progression to Alzheimer's disease. More...21 Dec 2020
Gene Expression Signature Traces Nonalcoholic Fatty Liver Disease Progression
Nonalcoholic fatty liver disease (NAFLD) is a common condition marked by the accumulation of triglycerides and other lipids in the liver and is associated with metabolic syndrome, type 2 diabetes, hypertension, and dyslipidemia. More...16 Dec 2020
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Genetic Testing channel of LabMedica brings the latest in molecular genetics, cytogenetics, and epigenetics, and methods from PCR to FISH, and more.