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Molecular Diagnostics

Image: Highly effective early diagnostic tests could revolutionize cancer detection.  Here, a sample is dropped onto a disposable Dxcover Slide and dried for analysis (Photo courtesy of Dxcover Limited)

A Novel Liquid Biopsy Spectroscopy Method for Early Detection of Brain Tumors

A blood-based liquid biopsy approach enables detection of brain tumors that are so small and low-grade that the patient will often have few or no symptoms. More...
16 Aug 2021
Interstitial lung disease affects gas flow in the alveoli (courtesy of: Wikimedia Commons)

A Circulating Adipokine Is a Possible Biomarker for Severity of Systemic Sclerosis-Associated Interstitial Lung Disease

A circulating adipokine (a cytokine chemical messenger produced by adipose tissue) has been identified as a possible biomarker associated with the severity of systemic sclerosis-associated interstitial lung disease. More...
15 Aug 2021
The Applied Biosystems 3500xL Genetic Analyzer (Photo courtesy of Thermo Fisher Scientific).

Lipid Metabolism Affects GBA-Associated Parkinson's Disease

Parkinson’s disease (PD) is the most common neurodegenerative disorder after Alzheimer’s disease. The pathognomonic hallmark of PD is the degeneration of dopaminergic neurons of the substantia nigra and, consequently, the striatal dopamine depletion. More...
13 Aug 2021
The QiaSymphony DSP DNA Midi kit (Photo courtesy of Qiagen)

Genomes of Advanced Neuroendocrine Neoplasms Unveil Subtypes

Metastatic and locally-advanced neuroendocrine neoplasms (aNEN) form clinically and genetically heterogeneous malignancies, characterized by distinct prognoses based upon primary tumor localization, functionality, grade, proliferation index and diverse outcomes to treatment. More...
13 Aug 2021
Bone marrow aspirate from a patient with Precursor T-cell Acute Lymphoblastic Leukemia (Photo courtesy of Dr. Peter Maslak, MD)

Early T-Cell Precursor Lymphoblastic Lymphoma Characterized

T-cell lymphoblastic lymphoma (T-LLy) is an aggressive neoplasm of immature T-cell precursors and represents 25% to 30% of childhood non-Hodgkin lymphoma. More...
13 Aug 2021
The MiSeqDx System is the first FDA-regulated, CE-IVD-marked, NGS platform for in vitro diagnostic (IVD) testing (Photo courtesy of Illumina)

Insulin Resistance and T2D Associated With Gut Microbial Diversity

Type 2 diabetes (T2D) is a common complex metabolic disorder. Currently, more than 380 million people live with type 2 diabetes globally, and this number is expected to increase to more than 550 million by 2030. More...
13 Aug 2021
The SuperScript III Reverse Transcriptase (RT) kit provides increased specificity with gene-specific primers (GSPs) and the highest cDNA yield of all RTs (Photo courtesy of Thermo Fisher Scientific).

Molecular Assays Compared For MRD Detection In B-ALL

B-cell precursor acute lymphoblastic leukemia (B-ALL) is the most common malignancy in children, and it may be associated with gene alterations that regulate B-cell development. The prognostic significance of minimal residual disease (MRD) in children with acute lymphoblastic leukemia (ALL) has been demonstrated. More...
11 Aug 2021
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Genetic Testing channel of LabMedica brings the latest in molecular genetics, cytogenetics, and epigenetics, and methods from PCR to FISH, and more.