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Molecular Diagnostics

Image: Strong nuclear and cytoplasmic p16 staining of a section from an HPV+ oropharynx tumor. Lymphocytes (blue arrow) and endothelial cells (black arrow) are unstained (Photo courtesy of Jonathon McHugh, MD)

TTMV-HPV DNA Biomarker Predicts Recurrence of Oropharynx Cancer

A large, multi-institutional study demonstrates that a blood test to detect circulating tumor DNA can accurately predict recurrence of HPV-driven oropharyngeal cancer following treatment. Results also indicate that the biomarker test may detect recurrent disease earlier than imaging or other standard methods of post-treatment surveillance, allowing physicians to personalize treatment more quickly for patients whose cancer returns. More...
03 Mar 2022
Image: Lipoprotein(a), or Lp(a), is a distinctive particle with two components: a lipoprotein core that resembles LDL, along with a shell that contains apolipoprotein(a), or apo(a).

Two Important Cardiovascular Disease Risk Factors Operate Independently

Determination of blood levels of the cholesterol-rich biomarker lipoprotein(a) [Lp(a)] and the coronary artery calcium (CAC) score are independently associated with risk of developing coronary artery disease and may be useful concurrently for guiding therapy approaches to prevent its occurrence . More...
02 Mar 2022
Image: Dr. Randall J. Bateman inspects a mass spectrometry instrument like that used to develop a blood test that is up to 93% accurate at identifying people at risk of Alzheimer`s disease (Photo courtesy of Matt Miller)

Sensitive Diagnostic Test for Alzheimer’s Disease Demonstrates Accuracy Over Multiple Laboratories and Protocols

The diagnostic accuracy of a blood test that assesses whether amyloid plaques have begun accumulating in the brain based on the ratio of the levels of the amyloid beta proteins ABeta42 and ABeta40 was confirmed in a recent study. More...
01 Mar 2022
Image: Schematic of melanoma (skin cancer) (Photo courtesy of 123rf.com)

Novel Biomarkers Predict Response of Melanoma Patients to Immunotherapy

A recent paper described a way to use blood bioenergetics and metabolomics as predictive biomarkers to determine melanoma patients’ response to immune checkpoint inhibitor therapy. More...
28 Feb 2022
Image: Schematic Diagram of Whole-Genome Sequencing that was used to diagnose neurological repeat expansion disorders (Photo courtesy of Centers of Disease Control and Prevention)

Whole-Genome Sequencing Diagnoses Neurological Repeat Expansion Disorders

Scientists have found whole genome sequencing (WGS) can quickly and accurately detect the most common inherited neurological disorders – something previously thought to be impossible – with the results supporting the use of WGS as a standard diagnostic tool within routine clinical practice. More...
25 Feb 2022
Image: Bone marrow of a pediatric patient with acute myeloid leukemia (Photo courtesy of St. Jude Children’s Research Hospital)

High-Risk Subtype of Relapsed Pediatric Acute Myeloid Leukemia Revealed

Scientists have found a previously overlooked mutation in a subtype of pediatric leukemia that has implications for identifying high-risk patients. More...
25 Feb 2022
Image: Representation of the structure of C-reactive protein (CRP) (Photo courtesy of Wikimedia Commons)

C-reactive Protein Level Can Replace Erythrocyte Sedimentation Rate for Defining the Severity of Ulcerative Colitis

A research team in Australia has determined that a blood level of C-reactive protein equal to or greater than 12 milligrams/liter is a practical alternative to measurement of ESR (Erythrocyte Sedimentation Rate) for defining the severity of ulcerative colitis. More...
24 Feb 2022
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