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Molecular Diagnostics

Image: Micrograph image of human papilloma virus associated oropharyngeal cancer (HPV+ OPSCC). The tissue was stained to show the presence of the virus by in situ hybridization (Photo courtesy of Wikimedia Commons)

Sensitive PCR Test Predicts Treatment Response in Metastatic Head and Neck Cancers

A recently developed droplet digital PCR (ddPCR)-based assay for circulating tumor DNA (ctDNA) from human papillomavirus HPV16 (which is responsible for almost 90% of HPV-positive oropharyngeal cancers) predicts treatment response in metastatic human papillomavirus related (HPV+) oropharyngeal squamous cell carcinoma (OPSCC). More...
06 Jul 2021
Image:  The Galleri test is able to detect multiple types of cancers through a single blood draw (Photo courtesy of GRAIL, Inc.)

Blood-based Liquid Biopsy Test Accurately Detects More Than Fifty Types of Cancer

Results from a clinical study confirmed that a noninvasive liquid biopsy-based blood test could accurately detect more than 50 types of cancer and could be used as a multi-cancer screening test among individuals at higher risk of the disease, including asymptomatic individuals aged 50 years or older. More...
05 Jul 2021
Image: Space-filling model of the antigen-binding fragment of atezolizumab (pale blue) in complex with PD-L1 (pink) (Photo courtesy of Wikimedia Commons)

Circulating Tumor DNA Following Surgery Predicts Bladder Cancer Recurrence

A blood test that detects circulating tumor DNA (ctDNA) predicts risk of bladder cancer recurrence following surgery and can be used to guide precision treatment of the disease. More...
01 Jul 2021
Image: Artist’s depiction of nanowire scaffolds for the screening of urinary microRNAs from patients with central nervous system tumors (Photo courtesy of Takao Yasui and Atsushi Natsume, Nagoya University)

A Nanowire-based Liquid Biopsy Method for Detection of Tumors of the Central Nervous System

Researchers have developed a sterilizable nanowire-based device that can efficiently extract urinary microRNAs (miRNAs) and used it as the basis of a liquid biopsy method to detect tumors of the central nervous system (CNS). More...
30 Jun 2021
Image: OncoMasTR is a six-gene signature test that can predict the likelihood of breast cancer spreading to a distant site in the body and reappearing (Photo courtesy of University College Dublin)

The OncoMasTR Test Accurately Identifies Risk of Breast Cancer Recurrence

A recent paper confirmed that the Oncomark (Dublin, Ireland) OncoMasTR test can accurately identify the risk for disease recurrence in patients with hormone receptor–positive HER2-negative early-stage breast cancer. More...
29 Jun 2021
Image: Xpert MTB/RIF Ultra assay is an automated molecular test that has improved the detection of tuberculosis and rifampicin resistance (Photo courtesy of Cepheid)

Highly Sensitive Molecular Test Detects Cases of Tuberculosis

Tuberculosis (TB) is a bacterial infection spread through inhaling tiny droplets from the coughs or sneezes of an infected person. It mainly affects the lungs, but it can affect any part of the body, including the tummy (abdomen), glands, bones and nervous system. More...
28 Jun 2021
Image: Thrombospondin 2 is a new diagnostic and prognostic serum biomarker in NAFLD (Photo courtesy of Osaka University)

Serum Thrombospondin 2 Identified as Biomarker for Patients at Risk of Nonalcoholic Fatty Liver Disease

Serum levels of the glycoprotein thrombospondin 2 (TSP-2) were shown to be a useful biomarker for non-alcoholic steatohepatitis (NASH) and advanced fibrosis diagnosis in nonalcoholic fatty liver disease (NAFLD) patients. More...
28 Jun 2021
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