Molecular Diagnostics
Five Genes Help Predict Lewy Body Dementia
Lewy body dementia usually affects people over 65 years old. Early signs of the disease include hallucinations, mood swings, and problems with thinking, movements, and sleep. Patients who initially have cognitive and behavioral problems are usually diagnosed as having dementia with Lewy bodies, but are sometimes mistakenly diagnosed with Alzheimer’s disease. More...10 Mar 2021
Low Lymphocyte Counts Linked to More Severe Sarcoidosis Inflammation
A recent paper identified unique phenotypes of sarcoidosis and demonstrated the relationship between these phenotypes and inflammatory activity, as measured by serologic markers of inflammation and avidity on 18FDG-PET/CT scan. More...09 Mar 2021
Clinical Germline Testing Evaluated for Pediatric Cancer Patients
Pediatric cancer is rare, with fewer than 10,000 solid tumors diagnosed in children annually in the USA. Previous studies interrogating germline predisposition broadly across pediatric cancer types have found heritable germline predisposition in 8%–12% of patients. More...04 Mar 2021
Genetic Risk of Inflammatory Bowel Disease Appears Distinct in African Americans
The inflammatory bowel diseases Crohn’s disease (CD) and ulcerative colitis (UC) arise in the context of inappropriate activation of the intestinal immune system in response to an environmental trigger in individuals who are genetically predisposed. More...03 Mar 2021
ctDNA Provides Prognostic Clues in Advanced BRAF-Mutated Melanoma Cases
A BRAF mutation is a change in a BRAF gene. That change in the gene can lead to an alteration in a protein that regulates cell growth that could allow the melanoma to grow more aggressively. Approximately half of melanomas carry this mutation and are referred to as mutated, or BRAF positive. More...02 Mar 2021
Rapid Lateral Flow Assays Detect COVID-19 Variants and Differentiate COVID-19 from Other Respiratory Viral Diseases
A recent publication reported the development of two rapid diagnostic tests - one that detects COVID-19 variants and one that differentiates COVID-19 from other respiratory viral diseases. More...02 Mar 2021
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In Other News
Elevated Plasma Levels of Glial Fibrillary Acidic Protein Indicate Increased Alzheimer’s Risk
Pulse-Controlled Amplification Tested for Infectious Disease Diagnostics
22-Gene Genomic Classifier Validated in Recurrent Prostate Cancer Patients
Plasma or Urine Liquid Biopsy Tests May Guide Colorectal Cancer Treatment
Proteogenomic and Metabolomic Studies Characterize Human Glioblastoma
Study Confirms Value of the MyProstateScore Urine Test for Prostate Cancer Screening
Next Generation Sequencing Finds More Gene Mutations for Leukemia
Exome Sequencing Identified Pathogenic Variants in Cerebral Palsy Patients
Analysis of Cell-free DNA in the Blood May Replace Examination of Biopsy Specimens for Disease Diagnosis
NanoString Technology Modernizes Liposarcoma Diagnostics
TFP Inhibitor Levels Elevated in Bleeding Tendency Patients
Prolonged Maternal Zika Viremia Evaluated for Adverse Perinatal Outcomes
Early Plasma Biomarkers Discovered for Alzheimer's Disease
TAP1 Gene Polymorphisms Associated with Recurrent Respiratory Papillomatosis
Liquid Biopsy Allows Monitoring of COVID-19 Damage to Cells, Tissues, and Organs
Blood Test Detects Early Colorectal Adenomas
Precise Measurement of DNA Length Polymorphisms Used to Diagnose Acute Myeloid Leukemia
Liquid Biopsy Predicts Colon Cancer Relapse Months Earlier
Cell-Free DNA Detects Heart Allograft Acute Rejection
AI-guided Immunoassay Measures Maternal Autoantibodies to Predict Likelihood of Autism Spectrum Disorder
A Rapid AI-based Screening Test for Prostate Cancer Biomarkers in Urine
ABO Histo-Blood Groups Influence Makeup of Gut Microbiome
Specific RUNX1 Mutations Cause Different Disease Types
Genetic Testing channel of LabMedica brings the latest in molecular genetics, cytogenetics, and epigenetics, and methods from PCR to FISH, and more.