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Molecular Diagnostics

Image: Structure of the neutrophil gelatinase-associated lipocalin (uNGAL) protein (Photo courtesy of Wikimedia Commons)

A New Approach for Rapid Detection of Acute Kidney Injury in Children

Measurement of a urinary protein combined with a calculated renal angina index was used to identify the early signs of acute kidney injury in children. More...
10 Nov 2020
Image: The Qiagen miRNeasy serum/plasma miRNA isolation kit (Photo courtesy of Qiagen).

Molecular Blood Test Kit Detects Gastric Cancer Early

Gastric cancer (GC) is the fifth most common cancer and the third-leading cause of cancer deaths worldwide. GC mortality is high due to late presentation. In most countries, mass screening is neither feasible nor cost-effective because such screening methods are costly and invasive, with poor compliance. More...
09 Nov 2020
Image: The BreathSpec was designed for the analysis of VOCs (Volatile Organic Compounds) metabolic profiles in human breath (Photo courtesy of IMSPEX)

A Breath-Analysis Test for Rapid Diagnosis of COVID-19

Researchers have reported the development of a rapid breath-analysis test that detects COVID-19 by identifying significant changes in the exhaled concentrations of a panel of volatile organic compounds. More...
09 Nov 2020
Image: MinION flow cell for DNA analysis (Photo courtesy of Oxford Nanopore Technologies Ltd.)

A Liquid Biopsy for Diagnosis of Pediatric High-Grade Glioma

A liquid biopsy approach that detects cell-free tumor DNA (cf-tDNA) in samples of cerebrospinal fluid has been used to diagnose pediatric high-grade glioma (pHGG), a rare but usually fatal childhood brain cancer. More...
04 Nov 2020
Image: The NovaSeq 6000 Sequencing System (Photo courtesy of Illumina).

Single-Cell Sequencing Reveals Clonal Diversity Among AML Patients

A growing body of evidence supports the role of clonal diversity in therapeutic resistance, recurrence, and poor outcomes in cancer. Clonal diversity also reflects the history of the accumulation of somatic mutations within a tumor. More...
03 Nov 2020
Image: A molecular-scale illustration of single-atom nanoyzmes and their application as a signal labels in an immunoassay. On the left, illustration of a protein biomarker being captured and detected in an immunoassay (Photo courtesy of Washington State University)

Artificial Enzyme Increases Sensitivity of Alzheimer's Disease Immunoassay

A novel modification made to the classic ELISA method for detecting the Alzheimer's disease biomarker amyloid beta 1-40 increased the sensitivity of the test by more than a factor of 10. More...
03 Nov 2020
Image: A neural stem cell model of sporadic congenital hydrocephalus (Photo courtesy of Yale University School of Medicine).

Genetic Alterations Associated with Sporadic Congenital Hydrocephalus

Congenital hydrocephalus (CH), characterized by enlarged brain ventricles, is considered a disease of excessive cerebrospinal fluid (CSF) accumulation and thereby treated with neurosurgical CSF diversion with high morbidity and failure rates. More...
02 Nov 2020
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Genetic Testing channel of LabMedica brings the latest in molecular genetics, cytogenetics, and epigenetics, and methods from PCR to FISH, and more.
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