Molecular Diagnostics

Single Cell Characterization Acral Melanoma Identifies Novel Targets for Immunotherapy
Acral melanoma is a rare subtype that represents roughly 3% of all melanoma cases. Unlike typical melanoma that occurs on sun-exposed skin, acral melanoma develops on the nonhair bearing skin of the soles, palm and nail beds. There is very little information known about the development of acral melanoma. More...16 Mar 2022

New Test Could Help Diagnose Lyme Disease Sooner and Determine Treatment Efficacy
Traditional tests for Lyme disease, caused by a bite from an infected tick, can stay positive for prolonged periods of time after treatment, making it difficult for clinicians to diagnose persistent Lyme disease cases. Now, researchers have identified just such a testing mechanism that detects a type of antibody that infected individuals produce against a substance the Lyme bacteria acquires from the host in order to grow. More...16 Mar 2022

Expression, Microbiome Features Provide Pre-Treatment Lung Function Clues for Pediatric Patients
Microbial community and host gene expression features in lung samples may provide pre-treatment clues to risky lung function features in children receiving bone marrow transplants from healthy donor individuals, new research suggests. More...15 Mar 2022

Next-Gen Graphene Biosensor Technology Enables Lab Quality Diagnostics of Infectious Diseases, Anytime, Anywhere
A new novel graphene-based electronic biosensor technology under development aims to provide rapid, simultaneous, lab-grade accuracy detection of an array of infectious diseases, anytime, anywhere, by any user. More...14 Mar 2022

Two Circulating Biomarkers Predict Cardiovascular Disease Risk in Psoriasis Patients
Blood levels of the protein biomarkers cardiac troponin I (cTnI) and N-terminal pro-brain-type natriuretic peptide (NT-proBNP) in patients with psoriatic disease (PsD) were found to be associated with carotid plaque burden and the development of cardiovascular disease (CVD) independent of traditional CVD risk factors. More...11 Mar 2022

Fecal Microbiome Signature Predicts Pancreatic Cancer Risk
Researchers have identified a molecular signature of 27 microorganisms in stool samples that is able to predict whether an individual is at high risk of developing pancreatic ductal adenocarcinoma, the most common form of pancreatic cancer. More...10 Mar 2022

Stem Cell Architecture Drives Myelodysplastic Syndrome Progression
Researchers from The University of Texas MD Anderson Cancer Center discovered that treatment resistance in patients with myelodysplastic syndromes (MDS) is caused by two distinct classes of stem cells and identified possible therapeutic approaches that target these cells. Their findings, which could have significant benefits for patients with disease progression, were published today in Nature Medicine. More...10 Mar 2022
In Other News
Single Test for Over 50 Genetic Diseases Cuts Diagnosis from Decades to Days
Paper-Based Portable Diagnostic Platform Accurately Detects Mosquito-Borne Diseases Under Field Conditions
Low-Cost Multiplexed Electrochemical Biomarker Detection Platform to Be Commercialized in POC Diagnostics
Inherited Cancer Risk Detected in Significant Subset of Wilms Tumor Cases
'Fingerprint' Machine Learning Technique Identifies Different Bacteria in Seconds
Liquid Biopsy of Cerebrospinal Fluid for Diagnosis of Medulloblastoma
Single-Antigen Assays Increase Clinical Laboratory's Ability to Identify Acceptable Donors for Transplants
Prognostic Test Identifies High Risk and Low Risk Smoldering Multiple Myeloma Patients
Epigenetic Biomarker Signature Predicts the Likelihood of Premature Birth
Semiconductor Microchip Detects Prostate Cancer Markers With Ultra-High Sensitivity
Biomérieux Launches Free Mobile App to Aid Clinicians in Emergency and Critical Care Diagnostics
Mitochondrial Damage May Explain the Increased Incidence of Hypertension in Black Adults
TTMV-HPV DNA Biomarker Predicts Recurrence of Oropharynx Cancer
Two Important Cardiovascular Disease Risk Factors Operate Independently
Sensitive Diagnostic Test for Alzheimer’s Disease Demonstrates Accuracy Over Multiple Laboratories and Protocols
Novel Biomarkers Predict Response of Melanoma Patients to Immunotherapy
Whole-Genome Sequencing Diagnoses Neurological Repeat Expansion Disorders
High-Risk Subtype of Relapsed Pediatric Acute Myeloid Leukemia Revealed
C-reactive Protein Level Can Replace Erythrocyte Sedimentation Rate for Defining the Severity of Ulcerative Colitis
Genome Sequencing Investigated for Prenatal Diagnosis of Fetal Structural Anomalies
Genetic Signature Predicts Patients’ Response to Gastric Cancer Therapy
LumiraDx C-Reactive Protein (CRP) Test Achieves CE Marking
New Method for Three-Dimensional Analysis of Cancer Cells Shows Diagnostic Potential
Genetic Testing channel of LabMedica brings the latest in molecular genetics, cytogenetics, and epigenetics, and methods from PCR to FISH, and more.