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Molecular Diagnostics

Image: Randox Discovery Diagnostic Analyzer Wins 2021 Red Dot Award for High Design Quality (Photo courtesy of Randox Laboratories)

Randox Discovery Diagnostic Analyzer Wins 2021 Red Dot Award for High Design Quality

Randox Laboratories’ (Crumlin, UK) Discovery, a diagnostic analyzer which can consolidate molecular and immunoassay testing on one compact benchtop platform, has received the 2021 Red Dot Award for High Design Quality. More...
16 Apr 2021
Image: Immune T cells lymphocytes can seek and destroy a cell (green) infected with and making copies of SARS-CoV-2 (yellow) (Photo courtesy of US National Institute of Allergy and Infectious Diseases)

T Cells Recognize Recent SARS-CoV-2 Variants

Due to the proofreading ability of the coronavirus (CoV) RNA-dependent RNA polymerase, the evolution of the global SARS-CoV-2 viral population during the current pandemic has been relatively constrained as compared to other endemic RNA viruses that do not possess this ability. More...
15 Apr 2021
Image: Oxylipin biosynthesis reinforces cellular senescence and allows detection of senolysis (Photo courtesy of Dr. Christopher Wiley)

Novel Lipid Biomarker Detects Senescent Cells

A recent paper identified a lipid biomarker indicative of cellular senescence and described a method to evaluate its effect on the molecular events that lead to senescence. More...
13 Apr 2021
Image: The EZ DNA Methylation-Direct Kit (Photo courtesy of Zymo Research)

Leukocyte Epigenomics and Artificial Intelligence Predict Late-Onset Alzheimer’s Disease

Alzheimer’s Disease (AD) is the most common form of age-related dementia, accounting for 60%–80% of such cases. The disorder causes a wide range of significant mental and physical disabilities, with profound behavioral changes and progressive impairment of social skills. More...
12 Apr 2021
Image: APM2 overexpression increases the expression of the ERCC6L gene (Photo courtesy of Niigata University)

A Protein Biomarker Aids Cancer Patients by Controlling the Dosage of Highly Toxic Cisplatin

A team of Japanese investigators has identified a protein biomarker that may help clinicians control the dosage of the highly toxic chemotherapeutic drug cisplatin. More...
12 Apr 2021
Image: The BD FACSAria III sorter is equipped with five lasers, 17 fluorescence channels and two channels for Forward Scatter and Side Scatter (Photo courtesy of BD Biosciences)

Genome Sequencing Identifies Myeloma Precursor Disease with Progression Risk

Multiple myeloma (MM) is the second most common hematological malignancy and is consistently preceded by the asymptomatic expansion of clonal plasma cells, termed either monoclonal gammopathy of undetermined significance (MGUS) or smoldering myeloma (SMM). More...
08 Apr 2021
Image: Bone marrow aspirate from a child with a mediastinal tumor shows an invasion with neuroblastoma cells and characteristic images of neuropile threads (Photo courtesy of Mohammed Bensalah, MD, Amina Lyagoubi, and Rachid Seddik)

Single-Cell Transcriptomic Analysis Traces Neuroblastomas to Developing Adrenal Neuroblasts

Neuroblastoma is the most common cancer in infants and the third-most common cancer in children after leukemia and brain cancer. Approximately one in every 7,000 children is affected at some time and about 90% of cases occur in children less than five years old, and it is rare in adults. More...
07 Apr 2021
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