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Molecular Diagnostics

Image: The Lena Q51 leukemia diagnostic test will be launched in January 2023 (Photo courtesy of Alercell)

First Leukemia Diagnostic Test Based on DNA Sequencing Detects up To 51 Gene Mutations

Until 2022 the only leukemia tests done could detect two gene mutations. Now, a new leukemia diagnostic test is capable of detecting 51 gene mutations, marking a significant technological and medical advancement. More...
02 Jan 2023
Image: A blood test can detect a novel marker of Alzheimer’s disease neurodegeneration (Photo courtesy of Pexels)

Biomarker Test Detects Alzheimer’s Neurodegeneration in Blood

Scientists have applied their knowledge of molecular biology and biochemistry of tau proteins in different tissues, such as the brain, to develop a technique to selectively detect “brain-derived tau,” or BD-tau, a novel marker of Alzheimer’s disease neurodegeneration, while avoiding free-floating “big tau” proteins produced by cells outside the brain. More...
28 Dec 2022
Image: GridION MK1 is a cost-effective and compact benchtop system offering on-demand sequencing with integrated real-time data processing (Photo courtesy of Oxford Nanopore Technologies).

Tuberculosis Pathogen Dynamics Detected With Nanopore Sequencing

Mycobacterium tuberculosis whole-genome sequencing (WGS) has been widely used for genotypic drug susceptibility testing (DST) and outbreak investigation. For both applications, Illumina technology is used by most public health laboratories. More...
26 Dec 2022
Image: Anaplasma phagocytophilum morulae (arrowed) in the cytoplasm of white blood cells (Photo courtesy of Johan S.Bakken, MD, PhD and Stephen Dumler, MD)

Real-Time PCR-Based Serological Diagnosis of Human Granulocytic Anaplasmosis

Human granulocytic anaplasmosis (HGA) is a tick-borne infection caused by the intracellular bacterium Anaplasma phagocytophilum, an emerging pathogen. HGA can manifest as a subclinical infection; however, most symptomatic persons have fever, myalgia, and headache associated with thrombocytopenia, leukopenia, and elevated transaminase levels. More...
26 Dec 2022
Image: New blood test to identify infections could reduce global antibiotic overuse (Photo courtesy of Pexels)

Blood Test to Separate Bacterial and Viral Infections Could Reduce Antibiotic Overuse

A new gene expression-based test could allow doctors around the world to quickly and accurately distinguish between bacterial and viral infections, thereby cutting down on antibiotic overuse. More...
26 Dec 2022
Image: Illustration of the principle underlying the detection of trace amounts of proteins (Photo courtesy of OMU)

Ultrafast, Ultra-Sensitive Protein Detection Method Enables Ultra-Early Disease Diagnosis

Methods to analyze trace amounts of proteins based on antigen–antibody reaction enable diagnosis at an early stage of many diseases, including cancer, dementia, and microbial infections. Now, a team of scientists has discovered a new principle underlying light-induced acceleration of antigen–antibody reaction, allowing for simple, ultrafast, and highly sensitive detection of proteins. More...
23 Dec 2022
Image: The iPeak Europium lateral flow reader for fluorescence-labeled lateral flow tests (Photo courtesy of IUL SA)

Extremely Sensitive Fluorescence Lateral Flow Reader Detects Even Low Positives Results

Presently, fluorescence lateral flow tests represent an affordable alternative to the PCR tests guaranteeing a high sensitivity and specificity. Now, an off-the-shelf lateral flow reader designed to scan fluorescence-labeled lateral flow tests represents a fundamental advance in this field. More...
22 Dec 2022
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Genetic Testing channel of LabMedica brings the latest in molecular genetics, cytogenetics, and epigenetics, and methods from PCR to FISH, and more.
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