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Molecular Diagnostics

Image: The Genome Sequencer 454FLX system (Photo courtesy of Roche).

Real-Time Genome Sequencing Helps Control Hospital Outbreak

Whole-genome sequencing (WGS) of bacterial isolates provides a promising contemporary method for investigating the epidemiology of outbreaks, particularly when coupled to clinical locational and temporal data.   More...
01 Dec 2014
Image: The BN II protein analyzer system (Photo courtesy of Siemens).

Sickle Cell Trait Linked to Chronic Kidney Disease Risk

Sickle cell trait is defined as inheritance of a single copy of the sickle mutation that results from a single base pair substitution in the gene encoding the β-globin chain of hemoglobin.   More...
30 Nov 2014

Next-Generation Sequencing of Targeted Capture Genes a Sensitive Method for Diagnosis of Inherited Eye Disorders

A recent study showed that a targeted enrichment and next-generation sequencing method for genetic diagnostic testing of patients with inherited eye disorders was more accurate and sensitive than an approach based on exome sequencing, which focuses on the DNA in the 1% of the human genome that code for proteins.  More...
30 Nov 2014
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DNA Sequencing Identifies Mitochondrial Mutations in Glaucoma Patients

Diagnosis of glaucoma may be simplified by the development of a gene sequencing technique that detects mutations in the mitochondrial DNA of glaucoma patients.   More...
26 Nov 2014
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Human Genome Mapping Gaps Found by Latest Technology

Thousands of never-before-seen genetic variants in the human genome have been uncovered using a new genome sequencing technology and these discoveries close many human genome mapping gaps that have long resisted sequencing.  More...
26 Nov 2014
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Molecular Test Identifies Acute Transplant Rejection

The development of noninvasive molecular assays to improve disease diagnosis and patient monitoring is a critical need in renal transplantation, as acute rejection increases the risk for chronic graft injury and failure.  More...
25 Nov 2014
Image: Histopathology of ovarian serous papillary borderline tumor, intracystic, without surface cortical involvement (Photo courtesy of Brown University).

Prognostic Biomarker Candidates Identified for Ovarian Cancer

Two independent classes of novel candidate prognostic markers for ovarian cancer have been identified advancing efforts to develop targeted therapies for the disease.  More...
25 Nov 2014
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Genetic Testing channel of LabMedica brings the latest in molecular genetics, cytogenetics, and epigenetics, and methods from PCR to FISH, and more.