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Molecular Diagnostics

Image: The handheld device that can detect Ebola Virus Ribonucleic Acid (Photo courtesy of KIST Europe).

Palm-Sized Device Quickly Detects Ebola Virus

The gold standard method for identifying the Ebola virus in a blood sample requires packaging samples in cooled containers and sending them to specialized laboratories, often far away from where patients live. More...
18 May 2016
Image: A photomicrograph of an abnormal Pap smear showing changes consistent with Human Papilloma Virus (HPV) and Mild Dysplasia. Note the irregular perinuclear cytoplasmic clearing, which is the key characteristic of identifying HPV visually on a Pap smear (Photo courtesy of Dr. Cynthia D Booth, MD).

Combining Two Diagnostic Tests Drastically Reduces Cancer Miss Rates

The Papanicolaou (Pap) test is recommended for women between 21 and 65 years old as a screening test for cervical cancer. Women 30 and older who are negative on co-testing may wait as long as five years for their next testing, but physicians still recommend annual examinations. More...
17 May 2016
Image: A black cartridge containing the innovative paper-based diagnostic for detecting Zika virus: areas that have turned purple indicate samples infected with Zika virus, while yellow areas indicate Zika-free samples (Photo courtesy of Wyss Institute at Harvard University).

CRISPR-based Technology Enables High-Resolution Zika Detection On Low-Cost Paper Discs

Building off their earlier innovative development in “programmable diagnostics”, researchers on an international, multi-institutional team recently joined efforts to quickly prototype their low-cost rapid test with the goal that it could soon be used to screen samples (blood, urine, or saliva) for Zika virus and strain identification. More...
16 May 2016
Image: The MassARRAY Dx analyzer system (Photo courtesy of Agena Bioscience).

Diagnostic Tests For Lung And Colon Cancer Launched In Europe

A unique combination of reliability, sensitivity, ease of use, and cost-effectiveness for targeted genetic testing for cancer has now become available to molecular pathologists. More...
12 May 2016
Image: A histopathology of prostate cancer showing multiple poorly formed glands with ill-defined lumina and/or incomplete nuclear complement, Gleason score 3+4 = 7 (Photo courtesy of European Urology).

Non-Invasive Prostate Cancer Test Developed Using Exosomal RNA

The current screening paradigm for prostate cancer faces challenges that lead to unnecessary biopsies and, ultimately, overtreatment. The disadvantage of Prostate-Specific Antigen (PSA) testing is lack of specificity for prostate cancer resulting in both false positive and false negative results. More...
11 May 2016
Image: The Specificity of Recombinase Polymerase Amplification -Lateral Flow (RPA-LF) immunochromatographic strip to amplify species of the Viannia subgenus. The most relevant L. Viannia species (L. braziliensis, L. guyanensis, and L. panamensis) produced stronger bands in the lateral flow strip than other less common species of this subgenus. NTC= No template control (Photo courtesy of University of Texas Medical Branch).

Field-Applicable Molecular Test Diagnoses Tegumentary Leishmaniasis

Cutaneous and mucosal leishmaniases are widely distributed in Central and South America. Leishmania of the Viannia subgenus are the most frequent species infecting humans. L. (V.) braziliensis, L. (V.) panamensis are also responsible for metastatic mucosal leishmaniasis. More...
11 May 2016

Bacterial Vaginosis Assessed By Molecular Methods

Bacterial vaginosis (BV) is an aberrant state of the vaginal microbiota, which is characterized by a depletion of lactobacilli, an increased diversity of the bacterial population and an elevated pH. It is one the most common vaginal syndromes in fertile, premenopausal and pregnant women. More...
11 May 2016
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