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Molecular Diagnostics

Image: A photomicrograph of Leptospirosis bacteria magnified ×200 in a dark field optical microscope (Photo courtesy Dr. Steve H Fisyh).

Extended Multilocus Sequence Typing Developed for Leptospirosis

Leptospirosis is a zoonotic disease caused by pathogenic species of Leptospira that can be carried naturally by most mammalian species and transmission to humans most commonly occurs via direct animal contact or via water contaminated with animal urine. More...
05 Oct 2016
Image: A low-magnification micrograph showing peripheral neuropathy (vasculitis) (Photo courtesy of Wikimedia).

Genetic Cause Deciphered for Inherited Nerve Damage Afflicting Older Adults

An international team of researchers has identified a gene, MME, with a causative link to late-onset autosomal dominant axonal polyneuropathies. Patients initially develop loss of sensation and pain, then the illness can advance rapidly and lead to paralysis, inability to walk, and wheelchair dependency. More...
05 Oct 2016
Image: A scanning electron micrograph (SEM) of two mitochondria from mammalian lung tissue displaying their matrix and membranes (Photo courtesy of Wikimedia Commons).

DNA Analysis Clarifies Ancestry of Triple-Negative Breast Cancer Patients

Age of onset and severity of triple-negative breast cancer are related to ethnic origin, which can be definitively established by analysis of mitochondrial DNA. More...
04 Oct 2016

New Genes Implicated in High Blood Pressure Regulation

High blood pressure, or hypertension, affects one in three adults in the USA, according to the government authorities. The condition increases the risk for heart disease and stroke, but most people with high blood pressure are not aware they have it. More...
27 Sep 2016
Image: A scanning electron micrograph (SEM) shows an oral squamous cancer cell (white) being attacked by two cytotoxic T-cells (red). The tumor-specific T-cells were developed from the patient’s own immune system, a “personalized cancer vaccine” like those that may be developed in the future with the help of NIST’s standardized human genomes as reference materials (Photo courtesy of R.E. Serda / NCI).

New Standardized Whole Genomes Released to Improve Quality Control

Researchers have expanded the set of tools for more accurate next generation sequencing (NGS) analysis of genomes by developing 4 additional reference materials (RMs) to run as controls for assessing performance of the equipment, chemistry, and data analysis being used. More...
26 Sep 2016
Image: A colorized scanning electron micrograph (SEM) depicting two rod-shaped carbapenem-resistant Klebsiella pneumoniae (CRKP) bacteria interacting with a human neutrophil (Photo courtesy of the NIAID).

Test Developed for Healthcare-Acquired Infections Validated

Healthcare-acquired infections (HAIs) kill tens of thousands of people each year and add significantly to healthcare costs. Multidrug resistant and epidemic strains are a large proportion of HAI agents, and multidrug resistant strains of Klebsiella pneumoniae, a leading HAI agent, have become an urgent public health crisis. More...
22 Sep 2016
Image: A colorized scanning electron micrograph (SEM) of human prostate cancer cells (Photo courtesy of Dr. Gopal Murti).

Tumor Analysis Method Identifies High-Risk Prostate Cancer

A new way to identify which prostate cancer patients are likely to develop aggressive types of the disease, even if their tumors at first appear to be lower risk, has been created. More...
21 Sep 2016
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Genetic Testing channel of LabMedica brings the latest in molecular genetics, cytogenetics, and epigenetics, and methods from PCR to FISH, and more.