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Molecular Diagnostics

Image: A diagram of the method developed to detect and map DNA methylation, which can be a sign of cancer, by threading the DNA through a tiny hole in a thin sheet of conductive material with a current running through it (Photo courtesy of Aditya Sarathy, University of Illinois).

Detecting Cancer as DNA Changes Could Enhance Diagnosis

DNA methylation is an epigenetic modification involving the addition of a methyl group to DNA, which is heavily involved in gene expression and regulation, thereby critical to the progression of diseases such as cancer. More...
26 Apr 2017
Image: A photomicrograph of abnormal cervical cells staining positive for CINtec PLUS test (Photo courtesy of Ventana Medical Systems).

Cytology Test for Pre-Cancer Diagnosis Receives FDA Approval

A cytology test, which is the only clinically validated cyclin-dependent kinase inhibitor 2A (p16) biomarker test that, when used in conjunction with hematoxylin & eosin (H&E) staining, helps pathologists determine which women should receive treatment for cervical pre-cancer. More...
25 Apr 2017
Image: A Polymerase Chain Reaction (PCR) processing card for the BD Max molecular diagnostics platform (Photo courtesy of BD Diagnostic Systems).

Bacterial Panel Detects Stool Pathogens from Swabs

Repeated bouts of diarrhea and persistent diarrheal disease disrupt intestinal function and absorption, making diarrheal disease a leading cause of malnutrition in children less than 5 years of age. Importantly, diarrheal disease is both treatable when correctly diagnosed and preventable via proper infection control measures. More...
25 Apr 2017
Image: A comparison of analytical PCR procedures (Photo courtesy of Scientific Reports).

New sPCR Technology Runs on Standard Devices

Synergistic PCR (sPCR), a new method of DNA analysis developed for use on a new high-speed assay device, can also be carried out on widely available laboratory real-time PCR (qPCR) instruments and does not require calibration. More...
24 Apr 2017
Image: The structure of the tumor necrosis factor receptor 1 protein (Photo courtesy of Wikimedia Commons).

Serum Levels Predict Renal Disease Risk in Diabetes Patients

A team of epidemiology researchers has described a prognostic tool that accurately predicts the risk of end stage renal disease (ESRD) in patients with both type I and type II diabetes. More...
24 Apr 2017
Image: The droplet digital polymerase chain reaction system (Photo courtesy of Bio-Rad).

Gene-Based Blood Tests Identify More Skin Cancers

Genetic testing of tumor and blood fluid samples from people with and without one of the most aggressive forms of skin cancer has shown that two new blood tests can reliably detect previously unidentifiable forms of the disease. More...
20 Apr 2017
Image: The cobas TaqScreen WNV test: a real-time polymerase chain reaction (PCR) test to detect West Nile virus (WNV) RNA in plasma from blood, organ and tissue donor (Photo courtesy of Roche Diagnostics).

Routine Donor Screening Revealed Acute Usutu Virus

Usutu virus (USUV) an Old World flavivirus included in the Japanese encephalitis virus (JEV) antigenic complex is transmitted by mosquitoes to birds that act as the main amplifying hosts, while humans are considered incidental or dead-end hosts. More...
20 Apr 2017
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Genetic Testing channel of LabMedica brings the latest in molecular genetics, cytogenetics, and epigenetics, and methods from PCR to FISH, and more.
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