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Molecular Diagnostics

Image: The MammaPrint DNA microarray test for breast cancer prognosis (Photo courtesy of Agendia).

Genetic Test Reduces Post-Surgery Chemotherapy for Breast Cancer Patients

A genetic test identified a large group of patients for whom five-year distant metastasis-free survival was equally good whether or not they received adjuvant chemotherapy, chemotherapy given post-surgery. More...
04 May 2016
Image: The Cologuard testing kit for colorectal cancer (Photo courtesy of Exact Sciences).

Noninvasive Test Detects Colorectal Cancer in Unscreened Patients

A noninvasive colorectal cancer-screening test detected the disease in patients who had previously avoided more invasive screening measures. Colorectal cancer is the second deadliest form of cancer in the USA and this year, nearly 135,000 Americans will be diagnosed with the disease and 50,000 Americans will die of it. More...
03 May 2016

Patterns of MicroRNA Expression Distinguish Patients with Asthma and Allergic Rhinitis

Subsets of circulating micro RNAs (miRNAs) are uniquely expressed in asthmatic patients and in patients with allergic rhinitis (AR) and have potential for use as noninvasive biomarkers to diagnose and characterize these diseases. More...
29 Apr 2016
Image: The Benchmark Ultra IHC/ISH staining instrument (Photo courtesy of Ventana Medical Systems).

Genetic Link Confirmed Between DCIS And Invasive Disease

Inherited genetic links have been confirmed between non-invasive cancerous changes found in the milk ducts, known as ductal carcinoma in situ (DCIS) and the development of invasive breast cancer, meaning that a family history of DCIS could be as important to assessing a woman's risk as a history of invasive breast cancer. More...
28 Apr 2016
Image: The Pyromark Q96 MD pyrosequencing instrument (Photo courtesy of Qiagen).

DNA-Based Test Determines Degree Of Liver Fibrosis

Non-alcoholic fatty liver disease (NAFLD) accounts for the majority of liver disease burden in the Western world. Liver biopsy remains the gold standard test to accurately stage fibrosis in patients with NAFLD, but it is invasive and carries risks. More...
28 Apr 2016
underwent resection of tumor and adjacent normal tissue, followed by formalin fixation, pathologic characterization, and whole exome sequencing and analyses (Image courtesy of Giannakis et al 2016, Cell Reports).

Genomics Makeup of Colorectal Tumors Predicts Immune Response

A study based on whole-exome sequencing and immune response finds that colorectal cancers (CRCs) heavily bedecked with tumor-related neoantigens are likely to be permeated with disease-fighting white blood cells (WBCs). The discovery helps sharpen research into therapies that make tumors more vulnerable to such an attack and into companion diagnostics. More...
27 Apr 2016
Image: A micrograph of eosinophilic esophagitis (EoE), H&E stain. Characteristic features are present: Abundant eosinophils—criteria vary; one common definition is: > 20 eosinophils/0.24 mm2; Papillae are elongated; papillae reach into the top 1/3 of the epithelial layer; Basal cell hyperplasia; > 3 cells thick or >15% of epithelial thickness; Spongiosis (Photo courtesy of Wikimedia).

Pathway Implicated in Development of Eosinophilic Esophagitis

Scientists have identified a protein whose dysfunction appears to be involved in causing the tissue damage in patients with eosinophilic esophagitis (EoE). The finding may lead to improved pathology analysis, diagnostics, and specific drug therapies for patients. More...
26 Apr 2016
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Genetic Testing channel of LabMedica brings the latest in molecular genetics, cytogenetics, and epigenetics, and methods from PCR to FISH, and more.
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