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Molecular Diagnostics

Image: A photomicrograph of a blood smear from a patient with acute myeloid leukemia, with very large, immature myeloblasts with many nucleoli (Photo courtesy of the CDC).

Faulty Genetic Instructions Drive Deadly Leukemia in Adults

Acute myeloid leukemia is one of the most common acute leukemia or blood cancer types in adults, and involves over-production of immature blood cells that then crowd out normal, healthy cells. More...
06 Jul 2016
Image: An MRI scan of a brain lesion (white) in a patient with tuberculosis from the study. The yellow circle indicates the biopsy location (Photo courtesy of Johns Hopkins University).

Brain Infections Diagnosed Using Next-Generation Sequencing

The feasibility of next-generation sequencing (NGS) microbiome approaches in the diagnosis of infectious disorders in brain or spinal cord biopsies in patients with suspected central nervous system (CNS) infections has been investigated. More...
06 Jul 2016

Liquid Biopsy Biomarkers for Aggressive Prostate Cancer Discovered

Using targeted proteomics on noninvasive liquid biopsies, researchers have discovered biomarkers that provide signatures of aggressive (extracapsular) prostate cancer (PC), which could enable diagnosis before treatment and so help many low-risk PC patients avoid surgery. More...
05 Jul 2016
Image: The biosensor chip - consisting of a double stranded DNA probe embedded onto a graphene transistor - electronically detects DNA SNPs (Photo courtesy of the University of California, San Diego).

Biochip Combines Graphene Electronics and DNA Strand Displacement for Detection of Polymorphism Mutations

A team of bioengineers has designed an electronic biochip with potential applications for personalized medicine that can detect DNA mutations caused by single nucleotide polymorphisms (SNPs) in real time. More...
05 Jul 2016
Image: The 7500 Fast Dx Real-Time polymerase chain reaction (rt-PCR) instrument (Photo courtesy of Applied Biosystems).

Multiplex Molecular Test Developed for Three Arboviruses

Clinical manifestations of Zika virus, chikungunya virus and dengue virus infections can be similar. To improve virus detection, streamline molecular workflow, and decrease test costs, a multiplex real-time reverse transcription polymerase chain reaction (rt-PCR) for these viruses has been developed and evaluated. More...
30 Jun 2016
Image: The therascreen EGFR RGQ PCR Kit is an automated molecular assay designed to detect the presence of mutations in the epidermal growth factor receptor (EGFR) gene in non-small cell lung cancer (NSCLC) (Photo courtesy of Qiagen).

Liquid Biopsy Urine Test Detects Mutations In Lung Cancer

While lung cancer is one of the most aggressive malignancies, progress has been made in the advancement of therapeutic strategies against the disease and in particular, epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs). More...
29 Jun 2016
Image: The Aptima HIV-1 RNA qualitative assay (Photo courtesy of Hologic).

Earliest Stage of Human Immunodeficiency Virus Infection Analyzed

The first days after Human Immunodeficiency Virus infection are very important because sexual partners are exposed to extremely high risks of infection due to the subsequent high viral load in the infected person. More...
29 Jun 2016
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Genetic Testing channel of LabMedica brings the latest in molecular genetics, cytogenetics, and epigenetics, and methods from PCR to FISH, and more.
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