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Clinical Chemistry

Image: The IDS-iSYS Multi-Discipline Automated System Analyzer (Photo courtesy of Immunodiagnostic Systems)

Two Immunoassays Compared for Determination of Serum Vitamin D

Vitamin D is a fat-soluble steroid prohormone that is generated mainly in the skin by photochemical conversion of 7-dehydrocholesterol. 25-hydroxyvitamin D (25(OH)D) is its main storage form and is present in blood at very high concentration with respect to the active form 1,25-dihydroxyvitamin D. More...
06 Jul 2021
Image: The DxH 900 hematology analyzer enables the high-volume laboratory to achieve RBC, PLT and WBC differentials through near native-state cellular characterization (Photo courtesy of Beckman Coulter)

Monocyte Distribution Width Evaluated as a Sepsis Indicator

Most current automated hematology analyzers have enhanced cell counting functions including the addition of new cell types such as nucleated red blood cells or immature granulocytes, making it possible to obtain a precise quantification of peripheral blood cells in pathological conditions. More...
01 Jul 2021
Image: The Simoa HD-X analyzer is used with the Simoa NF-light assay is a digital immunoassay for the quantitative determination of NfL in serum, plasma and CSF (Photo courtesy of Quanterix)

Plasma Neurofilament Light Validated Biomarker for Neurological Conditions

In the management of neurological disorders, reliable and easily accessible biomarkers are needed to recognize or rule out an underlying neurodegenerative process contributing to cognitive decline at the earliest stage. More...
30 Jun 2021
Image: The D-10 Hemoglobin Testing System provides comprehensive, automated hemoglobin testing in a compact footprint, combining HbA1c and HbA2/F/A1c testing on a single platform (Photo courtesy of Bio-Rad)

Diabetic Biomarkers Concordance Compared in South African Blacks

Sub-Saharan Africa is projected to experience a significant increase in the prevalence of diabetes mellitus by in the near future and accurate, comparable prevalence estimates will be essential to planning and monitoring by public health authorities. More...
28 Jun 2021
Image: A molecular model of the spike proteins (red) of SARS-CoV-2 binding to the angiotensin-converting enzyme 2 (ACE2) protein, the receptor (blue) which is it’s entry route to the target cell (Photo courtesy of the Juan Gaertner/ Science Photo Library)

Plasma ACE2 Predicts Prognosis of COVID-19 Hospitalized Patients

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has caused a devastating global pandemic. The disease caused by SARS-CoV-2 infection has been termed coronavirus disease of 2019 (COVID-19) with clinical manifestations ranging from asymptomatic and subclinical infection to severe hyperinflammatory syndrome and death. More...
24 Jun 2021
Image: ARCHITECT STAT High Sensitivity Troponin-I blood test (Photo courtesy of Abbott Laboratories)

Troponin Testing Presents Problems in Kidney-Impaired People

High-sensitivity cardiac troponin (hs-cTn) assays have improved the diagnosis of myocardial infarction in patients with healthy kidney function and are now widely used in clinical practice. More...
24 Jun 2021
Image: A blood test for glucose may reveal hyperglycemia which has been evaluated as a risk factor in pancreatic cancer (Photo courtesy of Amit Akirov, MD)

Hyperglycemia Evaluated as a Risk Factor in Pancreatic Cancer

Pancreatic ductal adenocarcinoma (pancreatic cancer) has a five-year survival rate of 9%. Most patients are diagnosed with metastatic disease due to late presenting symptoms and only 10% to 20% are able to undergo surgery with a curative intent. More...
23 Jun 2021
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The Clinical Chemistry channel updates the reader on tests, techniques, and research in the field - from routine assays to specialized tests on blood, urine, enzymes, lipids, hormones and more.