Clinical Chemistry
Serum Extracellular Vesicle Arginase 1 Measured In T2DM
Serum extracellular vesicle (EV)-derived arginase 1 (ARG 1) plays a critical role in diabetes-associated endothelial dysfunction. This study was performed to determine the levels of serum EV-derived ARG 1 in T2DM and non-T2DM participants and to examine the association of serum EV-derived ARG 1 with T2DM incidence. More...18 Mar 2022
Biosensors Use Non-Invasive Urinalysis and AI for Quick Assessment of Cancer Treatment
A newly-developed system of synthetic biosensors will enable a patient and doctor to quickly learn if an immune checkpoint blockade (ICB) therapy is working through the use of non-invasive urinalysis and artificial intelligence (AI). More...18 Mar 2022
Proline-Specific Peptidase Activities in Plasma of Hospitalized COVID-19 Patients
COVID-19 patients experience several features of dysregulated immune system observed in sepsis. We previously showed a dysregulation of several proline-selective peptidases such as dipeptidyl peptidase 4 (DPP4), fibroblast activation protein alpha (FAP), prolyl oligopeptidase (PREP) and prolylcarboxypeptidase (PRCP) in sepsis. In this study, we investigated whether these peptidases are similarly dysregulated in hospitalized COVID-19 patients. More...16 Mar 2022
High-Sensitivity Troponin I Explored Post-Cardiac Surgery
Consensus recommendations regarding the threshold levels of cardiac troponin elevations for the definition of perioperative myocardial infarction and clinically important periprocedural myocardial injury in patients undergoing cardiac surgery range widely (from >10 times to ≥70 times the upper reference limit for the assay). Limited evidence is available to support these recommendations. More...07 Mar 2022
Repeatability and Reproducibility of a Handheld Quantitative G6PD Diagnostic
Novel treatment regimens for the radical cure of P. vivax malaria are more effective than current options but require prior quantitative G6PD testing. The reference method for quantitative G6PD measurement is spectrophotometry but, due to its operational characteristics, is not suitable for routine use. Furthermore, poor inter-laboratory reproducibility of spectrophotometry has prevented quantitative global definitions of G6PD deficiency. SD Biosensor (ROK) have developed a novel handheld “Biosensor” device (G6PD STANDARD), which measures G6PD activity within two minutes and has operational characteristics suited to point of care diagnosis. More...03 Mar 2022
Essential Amino Acids Associated With Complications in Liver Transplant Recipients
End stage liver disease is a major cause of morbidity and mortality worldwide and orthotopic liver transplantation (OLTx) is the only curative treatment. However, OLTx leads to its own risks and adverse sequelae. More...02 Mar 2022
Electrochemical Enzyme-Based Blood ATP and Lactate Sensor Monitors Disease Severity
Scientists have developed a prototype sensor that could help doctors rapidly measure adenosine triphosphate (ATP) and lactate levels in blood samples from patients, aiding in the rapid assessment of the severity of diseases. More...28 Feb 2022
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In Other News
Gold Nanoparticle-Based Electrode Marks Breakthrough in Urinalysis Disease Detection Methodology
Biomarker Panel For Risk of Early Respiratory Failure Following Hematopoietic Cell Transplantation
Calprotectin Fecal Assay Adapted for Serum Samples
Serum Glucose Identifies Hospitalized Stroke Patients at Greatest Risk for Recurrence
Blood Biomarkers May Distinguish Dementia Disorders
Simpler and Reliable ALS Diagnosis Enabled With Blood Tests
Genetic Clues Link Lipoprotein A to Prostate Cancer Risk
High NT-proBNP Paradoxically Shows Lower Risk in Early Pregnancy
New, Enzyme-Free Glucose Monitoring Sensor Solution Could Find Applications in Range of POC Diagnostics
ALT/AST Ratio Is an Independent Risk Factor for Gestational Diabetes Mellitus
Diagnostic Value of Serum CHI3L1 in Hepatocellular Carcinoma Explored
Proteomic Noninvasive Biomarkers Associated with Sport-Related Concussions
HOMA2-B Assessed for Type 1 Diabetes Risk
Fecal Immunochemical Test for Hemoglobin Evaluated on Automated System
Biochemical Parameters Compared for Diabetic Ketoacidosis Severity
Low Serotonin Levels Associated with Higher Nigral Iron in Parkinson’s Disease
Different Test Systems Analytical Performance Evaluated for Serum Creatinine
Blood Biomarker Kallikrein-8 Detects Amnestic Mild Cognitive Impairment
Nomograms Including Rapid Antigen Test Detects Primary Bladder Cancer
Near Normal Aminotransferase Levels Reported in Alcoholic Cirrhosis Patients
Serum High Sensitivity C-Reactive Protein Associated With Pre-Diabetes
Calprotectin Levels Vary When Measured in Different Matrices for COVID-19
Seasonal Temperature Impacts Patients’ Laboratory Results
The Clinical Chemistry channel updates the reader on tests, techniques, and research in the field - from routine assays to specialized tests on blood, urine, enzymes, lipids, hormones and more.
