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Clinical Chemistry

Image: Enzyme-linked immunosorbent assay for the determination of anti-drug antibodies (Photo courtesy of Matriks Biotek)

Biomarker Predicts Crohn's Disease Relapse in Children

Crohn's disease is a type of inflammatory bowel disease (IBD). It causes inflammation of the digestive tract, which can lead to abdominal pain, severe diarrhea, fatigue, weight loss and malnutrition. Other complications outside the gastrointestinal tract may include anemia, skin rashes, arthritis, inflammation of the eye, and lethargy. More...
22 Jun 2021
Image: The Leptin enzyme-linked immunosorbent assay is for the quantitative determination of leptin in human serum (Photo courtesy of the American Laboratory Products Company)

Serum Leptin Concentration Predict Cardiovascular Outcomes in Hemodialysis Patients

Leptin, a 16-kDa protein product mainly secreted by adipocytes, has been known to increase energy expenditure, suppress appetite, and leads to weight loss. Hyperleptinemia was common in maintenance hemodialysis (MHD) patients, and it was likely to be one of the causes of anorexia and malnutrition. More...
21 Jun 2021
Image: Blood test for  plasma aldosterone concentration was used to screen For hyperaldosteronism in hypertensive men (Photo courtesy of  VisitHealth Ltd)

Urinary Sodium/Potassium Ratio Screens for Hyperaldosteronism in Hypertensive Men

Among individuals with hypertension, the prevalence of secondary hypertension has been reported to be around 10%. More than half of individuals with secondary hypertension have associated hyperaldosteronism. More...
08 Jun 2021
Image: The Mindray BC-6800 hematology analyzer (Photo courtesy of Shenzhen Mindray Bio-Medical Electronics)

Platelet Indices Analyzed for Tuberculosis and Diabetes Mellitus Co-Morbidity

Studies have demonstrated that some diseases accelerate Tuberculosis (TB) occurrence and development. Type 2 diabetes mellitus (DM) has been verified as one of the threatening risk factors for TB, and patients have three times the risk of developing TB compared to non-diabetic patients due to pathogenic mechanisms and metabolic factors. More...
03 Jun 2021
Image: The YSI 2300 STAT Plus Glucose & Lactate Analyzer (Photo courtesy of YSI Life Science)

Low-Density Lipoprotein Cholesterol Is Associated with Insulin Secretion

Dyslipidemia is characterized by low levels of high-density lipoproteins (HDLs), hypertriglyceridemia, high total and low-density lipoprotein (LDL) cholesterol concentrations, as well as an increased proportion of small dense lipoproteins. More...
02 Jun 2021
Image: Computer-generated Mycobacterium tuberculosis bacteria, Ziehl-Neelsen stain. The reagents used are carbol fuchsin, acid alcohol, and methylene blue counterstain Acid-fast bacilli stain red and the background is blue (Photo courtesy of  microbiologyinpictures)

Serum Based Antigen Test Detects Childhood Tuberculosis

Approximately one million children develop tuberculosis (TB) and 205,000 die of TB-related causes each year. Eighty percent of these deaths occur in children < 5 years old, with the majority (96%) of deaths occurring among children who did not receive treatment, where missed diagnoses are likely responsible for undertreatment. More...
01 Jun 2021
Image: AB Sciex 4000Qtrap quadrupole mass spectrometer (Photo courtesy of Sciex)

Low Sugar Metabolite Associated with Disability, Neurodegeneration in MS

N-glycan branching modulates cell surface receptor availability, and its deficiency in mice promotes inflammatory demyelination, reduced myelination, and neurodegeneration. N-acetylglucosamine (GlcNAc) is a rate-limiting substrate for N-glycan branching. More...
27 May 2021
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The Clinical Chemistry channel updates the reader on tests, techniques, and research in the field - from routine assays to specialized tests on blood, urine, enzymes, lipids, hormones and more.
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