Clinical Chemistry
Maternal Multiomic Changes Could Predict Onset of Labor
Currently, predictions of when labor will start are imprecise and based on gestational age and an average pregnancy length of 40 weeks, even though the onset of labor between week 37 and 42 of pregnancy is considered normal. Having a better idea of when labor may arrive could help with planning and managing medical concerns like fetal lung maturation. More...18 May 2021
Meconium Microbiome Can Help Predict Risk of Developing Allergies
Meconium, which is typically passed within the first day of life, is made up of a variety of materials ingested and excreted during development, ranging from skin cells, amniotic fluid and various molecules known as metabolites. More...12 May 2021
ANGPTL8 Levels Associated with Hyperlipidemia in Primary Nephrotic Syndrome
The typical clinical manifestations of Primary Nephrotic Syndrome (PNS) include massive proteinuria, hypoproteinemia, edema and/or hyperlipidemia. Of these, marked proteinuria is the core clinical manifestation, and its severity often parallels the degree of hyperlipidemia. More...28 Apr 2021
Altered Perivascular Fibroblast Activity Precedes ALS Disease Onset
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease of the motor neurons that eventually causes muscular atrophy, paralysis and death. There is currently no cure. The cause of ALS is only understood in the 5% to 10% of patients who have an inherited form of the disease. More...28 Apr 2021
Blood-Based Markers Tied to Brain Cell and Memory Loss
Previous studies have linked elevated levels of plasma total tau and neurofilament light chain (NfL) with worse cognition and neuroimaging measures of cortical thickness, cortical atrophy, white matter hyperintensity, or white matter integrity. More...27 Apr 2021
Serum α-L-Fucosidase Activity Measured for COVID-19 Infection
An unusual fucosylated LacdiNAc in the receptor-binding domains of the spike protein of COVID-19 has been observed. Reduced fucosylation was also found in a specific Fc domain of IgG antibodies in COVID-19 patients that enhanced the interactions with the activating FcγR, FcγRIIIa. More...22 Apr 2021
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In Other News
Urinary Heat Shock Protein 70 Evaluated in Chronic Prostatitis
Breath Test Determines Severity of Methylmalonic Acidemia Disease
Vitamin D Deficiency Linked to Metabolic Changes in Lupus Patients
Circulating Calprotectin as Biomarker in Neutrophil-Related Inflammation
Coagulation Dysfunction and Infection Evaluated in Patients with AECOPD
High Liver Enzymes Increase Diabetes Risk for Hispanic Adults
Performance of Five Lipoprotein(a) Immunoassays Evaluated
Flow-Cytometric Expression of Endoglin Assessed in B-Acute Lymphoblastic Leukemia
NMR-Based Method Measures Circulating Blood Citrate Levels
Vitamin D Levels Tied to COVID-19 Risk for African-Americans
White Blood Cell Help Define Pediatric Urinary Tract Infections
Calcitonin and Procalcitonin Immunoassays Investigated for Medullary Thyroid Carcinoma
Chemiluminescence Anti‐Müllerian Hormone Assay Performance Characterized
Cardiac Troponins Assessed for Acute Heart Failure
CSF Biomarker Flags Parkinson's Pathology Much Earlier
Blood Biomarker Discovered for Autism Spectrum Disorder
Biomarker Protein Investigated in Juvenile Idiopathic Arthritis
Immune Response to Insulin Identifies Risk of Juvenile-Diabetes
Fibrinogen to Albumin Ratio Reflects ANCA‐Associated Vasculitis Activity
Three Automated Urine Analyzers Compared with Manual Microscopic Urinalysis
Stabilized Urinary Biogenic Amines Measured in Clinical Chemistry Laboratories
Biomarkers Evaluate Kidney Injury in Cancer Patients
Blood Test Distinguishes Epileptic Seizures From PNES
The Clinical Chemistry channel updates the reader on tests, techniques, and research in the field - from routine assays to specialized tests on blood, urine, enzymes, lipids, hormones and more.