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Clinical Chemistry

Image: Colored scanning electron micrograph of a Leishmania mexicana amastigotes (Photo courtesy of Zephyris).

Paper-Based Microfluidics Developed for Molecular Diagnostic Testing

A low cost, safe, disposable, rapid and self-sustainable paper-based platform for diagnostic testing, known as lab-on-paper, has been developed.   More...
01 Apr 2014
Image: CellSearch is a semiautomatic system that can capture and quantify circulating tumor cells from a blood sample with a high level of sensitivity and specificity (Photo courtesy of Janssen Diagnostics).

Circulating Tumor Cell Count Predicts Prostate Cancer Outcome Better Than PSA Measurement Does

A recent paper compared measurement of circulating tumor cells to determination of prostate specific antigen for prognosis of survival and drug response in patients with prostate cancer.  More...
01 Apr 2014
Image: Conventional Agarose Gel Electrophoresis for proteins (Photo courtesy of Helena).

Simplified Microchip Electrophoresis Rapidly Separates Urinary Proteins

A urine protein test is to detect the presence of protein in a person's urine, while in healthy individuals, there is only very low concentration of protein in urine, but in renal patients, the concentration of urine protein will increase considerably.  More...
27 Mar 2014
Image: The structure of the CEA125 protein. CEA125 has three domains: the N-terminal domain, tandem repeats domain and C-terminal domain. The N-terminal domain and tandem repeats are heavily glycosylated (Photo courtesy of Wikimedia Commons).

New Microarray-Based Glycoprofiling Test Diagnoses Ovarian Cancer

Cancer researchers have developed a microarray assay that identifies the abnormally glycosylated surface residues associated with ovarian tumor biomarker proteins such as CA125.  More...
27 Mar 2014
Image: Illumina HiSeq 2500 ultra-high-throughput sequencing system (Photo courtesy of Konrad Förstner).

New Gene Linked to Key Heart Attack Risk Factor

A previously unrecognized gene variation that makes humans have healthier blood lipid levels and reduced risk of heart attacks has been found.   More...
26 Mar 2014
Image: Ultra nano-liquid chromatography system (Photo courtesy of Eksigent).

Novel Candidate Protein Biomarkers Identified for Gastric Cancer

The early detection of stomach or gastric cancer has been revealed with the identification of four new biomarkers in the blood of human cancer patients.    More...
25 Mar 2014

Elevated Urinary Globotriaosylceramide Suggested as New Heart Disease Biomarker

Individuals with various forms of heart disease have been found to be a risk for a near term, potentially fatal cardiac event if they display high levels of urinary globotriaosylceramide.  More...
24 Mar 2014
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The Clinical Chemistry channel updates the reader on tests, techniques, and research in the field - from routine assays to specialized tests on blood, urine, enzymes, lipids, hormones and more.
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