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Clinical Chemistry

Image: The PLAC Test activity kit for measuring Lipoprotein-Associated Phospholipase A2 (Photo courtesy of diaDexus).

Lipoprotein-Associated Phospholipase A2 Tests Help Diagnose Heart Disease

The measurement of low-density lipoprotein cholesterol (LDL-C) or non-high-density lipoprotein cholesterol (non-HDL-C) is currently the mainstay when assessing the risk of atherosclerosis leading to cardiovascular disease. More...
19 Jul 2016
Image: According to new research, a blood test that leads to donor hearts being rejected may not effectively predict whether a heart transplant will succeed or fail (Photo courtesy of the AMA).

Heart Transplantation Recipients Unaffected by Donor Troponin Levels

Many transplant centers routinely reject hearts if the donor’s blood test reveals elevated levels of troponin I, a protein found in heart muscle that enters the bloodstream when there is a heart attack or other heart muscle damage. Donors with previous heart disease are automatically excluded. More...
14 Jul 2016
Image: The Thermo-Finnigan LTQ mass spectrometer (Photo courtesy of Thermo Fisher Scientific).

Plasma Mannose Levels May Indicate Diabetes Risk

Obesity is associated with an increased risk for a wide range of morbidities, including insulin resistance (IR), type 2 diabetes (T2D), non-alcoholic fatty liver disease (NAFLD), and cardiovascular disease (CVD). More...
14 Jul 2016
Image: The Cobas Mira S, a fully selective benchtop random access biochemistry analyzer (Photo courtesy of Roche).

Index Identifies Women at Risk for Rapid Bone Loss

Osteoporosis is often referred to as a "silent" disease because individuals who have it experience few noticeable symptoms and this progressive condition occurs when bones grow structurally weak and become more likely to fracture or break. More...
14 Jul 2016
Image: A histopathology of a meningioma with brain invasion (WHO Grade II); the tumor (bottom/right of image) has the typical \"pushing border\" invasion into the cerebral cortex (Photo courtesy of Nephron).

High Blood Sugar Associated with Lower Risk of Benign Tumors

Meningioma, is a primary tumor arising from the membrane surrounding the brain and spinal cord, accounts for more than one-third of all primary brain and central nervous system tumors. More...
07 Jul 2016
Image: Professor Michael Wheeler with Ashley St. Pierre of the Hospital for Sick Children, conducting additional tests in women with gestational diabetes to evaluate racial and ethnic differences in prediction, and investigate high-risk groups with prediabetes to learn if metabolomics will predict type 2 diabetes in the general population (Photo courtesy of the University of Toronto).

Highly Accurate Method Developed Predicts Postpartum Diabetes

Gestational diabetes is defined as glucose intolerance that is first identified during pregnancy and it occurs in 3% to 13% of all pregnant women, and increases a woman's risk of developing type 2 diabetes by 20% to 50% percent within five years after pregnancy. More...
06 Jul 2016
Image: The Elecsys 2010 immunology analyzer (Photo courtesy of Roche Diagnostics).

Cardiac Biomarker Increase Associated with Higher Risk of Heart Disease

High-sensitivity cardiac troponin T (hs-cTnT), a protein that can be measured via a blood test, is a biomarker of cardiovascular risk and cardiac troponin is critical to the clinical diagnosis of heart attack, particularly among symptomatic persons with chest pain. More...
30 Jun 2016
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The Clinical Chemistry channel updates the reader on tests, techniques, and research in the field - from routine assays to specialized tests on blood, urine, enzymes, lipids, hormones and more.
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