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Clinical Chemistry

Image: A new citrate-based material, made with naturally fluorescing polymer nanoparticles, can now be used for highly sensitive detection of chloride, a key marker of cystic fibrosis (Photo courtesy of the Yang Laboratory, Penn State University).

Low-Cost Sensor Developed for Cystic Fibrosis Diagnosis and Monitoring

Biomaterials scientists have developed an inexpensive method for detecting salt concentrations in sweat or other bodily fluids with a fluorescent sensor derived from citric acid molecules. The sensor is highly sensitive and highly selective for chloride, the key diagnostic marker in cystic fibrosis (CF). More...
04 Oct 2016

Simple Saliva Test Developed to Diagnose Asthma

Current clinical tests employed to diagnose asthma are inaccurate and limited by their invasive nature, but a new test that can diagnose asthma from a patient's saliva has now been developed. More...
29 Sep 2016
Image: The metabolic profiler system based on nuclear magnetic resonance (NMR) and mass spectrometry (MS) (Photo courtesy of Bruker BioSpin).

Protein Particle Parameters Help Differentiate Acute Kawasaki Disease

Kawasaki disease (KD) is a self-limited vasculitis that typically presents in young children as an acute illness with fever and mucocutaneous changes. If KD is incorrectly diagnosed or left untreated, coronary artery aneurysms (CAA) may develop, predisposing KD patients to long-term cardiovascular complications including myocardial ischemia and infarction. More...
28 Sep 2016
Image: The BS-380 automatic biochemistry analyzer (Photo courtesy of Mindray).

Novel Turbidimetric Immunoassay Evaluated for Fecal Calprotectin

Calprotectin is a multifunctional protein that plays an important role in the diagnosis and follow-up of inflammatory bowel disease and high levels of calprotectin in stool samples are associated with inflammation of the intestinal tract. More...
28 Sep 2016
Image: The cobas h 232 POC system, designed for use with the Elecsys high sensitivity cardiac troponin (hs-cTnT) assay (Photo courtesy of Roche).

Optimal Rule-Out Biomarker Strategy Developed for Acute MI

Assessment of patients presenting to the Emergency Department (ED) with symptoms suggestive of acute coronary syndrome (ACS) represents a major clinical challenge, since the majority of patients do not have a final diagnosis of acute myocardial infarction (AMI). More...
27 Sep 2016
Image: An Israeli desalination plant (Photo courtesy of Reuters).

Desalinated Water Linked to Cases of Iodine Deficiency

A study suggests and warns that relying on desalinated seawater as a population’s main source of drinking water can dramatically increase the prevalence of inadequate iodine intake, recommending individuals use iodized salt or other supplement and monitoring until an effective population-level solution has been found. More...
26 Sep 2016
Image: The VITROS ECiQ immunodiagnostic system (Photo courtesy of Ortho-Clinical Diagnostics).

Higher Thyroid Hormone Levels Linked to Sudden Cardiac Death

Thyroid hormone is made in the thyroid gland and circulates in the blood to help regulate nearly all of the body's organs, including the heart. Although the link between abnormal levels of thyroid hormone and cardiovascular disease is well established, the hormone's relationship with sudden cardiac death is unclear. More...
21 Sep 2016
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The Clinical Chemistry channel updates the reader on tests, techniques, and research in the field - from routine assays to specialized tests on blood, urine, enzymes, lipids, hormones and more.