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Clinical Chemistry

Image: The Affymetrix Genome-Wide Human SNP Array 6.0 features 1.8 million genetic markers including more than 906,600 single nucleotide polymorphisms (SNPs) and more than 946,000 probes for the detection of copy number variation (Photo courtesy of Thermo Fisher Scientific).

Type 2 Diabetes Misdiagnosed in African Americans

Glycated hemoglobin (HbA1c) is used to diagnose type 2 diabetes (T2D) and assess glycemic control in patients with diabetes. Previous genome-wide association studies (GWAS) have identified 18 HbA1c-associated genetic variants. More...
27 Sep 2017
Image: The infinite F50 absorbance reader (Photo courtesy of Tecan).

Low-Volume Aldosterone Immunoassay Validated for Small Samples

Heart failure is a severe cardiovascular disease in adults and children and is characterized by structural or functional abnormalities of the heart. Heart failure leads to an inappropriate blood circulation and subsequently to an undersupply of metabolizing tissues with oxygen and nutrients. More...
26 Sep 2017
Image: The back of the eye in a patient with age-related macular degeneration (AMD), showing multiple large drusen deposits and pigment changes (Photo courtesy of Massachusetts Eye and Ear Infirmary).

Potential Biomarkers of AMD Identified in Human Plasma

Patients with even an early stage of age-related macular degeneration (AMD) carry signs of the disease in their blood that may be detected through special laboratory tests, according to a new study. The findings may lead to earlier diagnoses, better prognostic information, and ultimately more precise treatments for earlier stages of AMD, the leading cause of blindness in people over age 50 in developed countries. More...
26 Sep 2017
Image: The Dionex Ultimate 3000 high-performance liquid chromatography (HPLC) system (Photo courtesy of the University of Texas at Austin).

Protein Network Mutations Impact Revealed in Bowel Cancer

The role proteins play in predicting how common mutations affect proteins in the cancer cells has been investigated and also whether such proteins are important in predicting the cancer's response to treatment. More...
22 Sep 2017
Image: Histopathology of breast cancer: intraductal carcinoma, comedo type, with distended duct with intact basement membrane and central tumor necrosis (Photo courtesy of Peter Abdelmessieh, DO, MSc).

Cholesterol Diagnosis Related to Breast Cancer Risk

Breast cancer is a malignancy that begins when cells grow abnormally in breast tissue. Although men can also develop breast cancer, it is much more common in women. Among women around the globe, breast cancer is the most common cancer and the fifth most common cause of cancer death. In 2012, nearly 1.7 million new cases, a quarter of all new cancer cases in women, were diagnosed worldwide. More...
22 Sep 2017
Image: The Viscotek high temperature gel permeation chromatography system (Photo courtesy of Malvern Instruments).

Mucin Concentration Used As Bronchitis Biomarker

Chronic bronchitis is characterized by recurring bouts of airway inflammation accompanied by a persistent cough and phlegm production. It is different from acute bronchitis, which typically develops after a cold or influenza and only lasts a few weeks. More...
22 Sep 2017
Image: The MasSpec Pen rapidly and accurately detects live cancer during surgery, helping improve treatment and reduce the chances of cancer recurrence (Photo courtesy of the University of Texas at Austin).

Handheld Mass Spectrometer Identifies Cancer Tissue in Seconds

A team of scientists and engineers has invented a powerful device that rapidly identifies living cancerous tissue, giving surgeons precise diagnostic information about what tissue to cut or preserve. More...
19 Sep 2017
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The Clinical Chemistry channel updates the reader on tests, techniques, and research in the field - from routine assays to specialized tests on blood, urine, enzymes, lipids, hormones and more.
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