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BioResearch

Image: The location of the FMR1 gene on the X chromosome (Photo courtesy of Wikimedia Commons).

Gene Editing Reverses Fragile X Syndrome in Model

A modified version of the CRISPR/Cas9 gene-editing tool was used to correct the mutation that causes fragile X syndrome. More...
05 Mar 2018
Image: Knee joints from control and FoxO deficient mice. The areas in red are joint cartilage, which is destroyed in FoxO deficient mice after treadmill running (Photo courtesy of the Lotz Laboratory, The Scripps Research Institute).

FOXO Protein Deficiency Linked to Osteoarthritis Severity

A mouse model that had been genetically engineered to lack FOXO (Forkhead box) proteins in cartilage was found to exhibit worse arthritis with aging and increased cartilage degradation in response to surgically induced arthritis. More...
03 Mar 2018
Image: The brain of a 10-month-old mouse with Alzheimer\'s disease (left) is full of amyloid plaques (red) surrounded by activated microglial cells (green). But these hallmarks of Alzheimer\'s disease are reversed in animals that have gradually lost the BACE1 enzyme (right) (Photo courtesy of The Cleveland Clinic and Rockefeller University Press).

Reducing Beta-secretase Reverses Alzheimer's Disease in Model

Employing a complex series of mouse models, a team of neurological disease researchers showed that reducing the level of the enzyme beta-secretase (BACE1) could reverse the clinical symptoms of Alzheimer's disease (AD). More...
01 Mar 2018
Image: Primary hepatocytes grown in a three-dimensional microfluidic \"liver-on-a-chip\" platform following infection with hepatitis B virus (Photo courtesy of Dr. Marcus Dorner, Imperial College London).

Liver-on-Chip Culture System Used to Study Hep B Infection

The potential value of an artificial "liver-on-chip" for biomedical research was demonstrated in a study that used the device to explore the mechanisms of hepatitis B infection and propagation. More...
28 Feb 2018
Image: Mouse blood vessel with plaque accumulation (Photo courtesy of the Sallam Laboratory, University of California, Los Angeles).

Long Non-coding RNA Reduces Arteriosclerosis Risk

A gene has been identified that produces a long non-coding RNA, which has been linked to the maintenance of cellular cholesterol balance and the development of arteriosclerosis. More...
27 Feb 2018
Image: A photomicrograph showing heart muscle cells that lack the dystrophin molecule (Photo courtesy of the University of Texas Southwestern Medical Center).

Studies Indicate Gene Editing May Cure Mutation-linked Disorders

Results of a series of proof-of-concept studies suggest that the CRISPR/Cas9 gene-editing tool might be used to correct mutation-related disorders such as Duchenne muscular dystrophy. More...
23 Feb 2018
Image: Osteoarthritis leads to the progressive loss of joint cartilage, shown in red (Photo courtesy of Nancy Liu/Denis Evseenko Laboratory, University of Southern California).

Novel Drug Candidate Reverses Arthritic Bone Loss in Models

A small molecule drug candidate was found to induce bone regeneration and reduce inflammation in various rat osteoarthritis models. More...
21 Feb 2018
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BioResearch brings the latest research news on the genome, proteome, metabolome, on drug discovery, and therapeutics. Biotech researchers, lab administrators, technologists, drug manufacturers, and suppliers can find the latest research news and information related to their fields of endeavor here.
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