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BioResearch

Image: With the new method, the researchers were able to image polyclonal antibody/HIV envelope complexes at a resolution of 4.7 angstroms. At this resolution, the researchers discovered that in rabbits, antibodies specific to a vulnerable site on HIV\'s outer glycan layer (blue shapes) are structurally highly convergent and closely resemble a previously isolated monoclonal antibody (green and teal ribbons) (Photo courtesy of Dr. Lars Hangartner, Scripps Research Institute).

Electron Microscopy Technique Boosts Development of Antibody-Based Vaccines

The novel use of an electron microscope imagining technique enabled vaccine developers to follow the design process of structure-based vaccines in real time. More...
22 Aug 2018
Image: A micrograph showing cellular senescence in human cells (Photo courtesy of Eva Latorre, University of Exeter).

Researchers Identify Two Proteins Required to Reverse Senescence

Two protein-splicing factors have been identified that enable mitochondria-targeted hydrogen sulfide to reverse senescence in endothelial cells. More...
21 Aug 2018
Image: In cells under duress, stress granules (in magenta) form outside of the nucleus (in blue). TDP-43 protein in green (arrow) that cannot bind to polyADP ribose (PAR) builds up in large clumps distinct from stress granules (Photo courtesy of Leeanne McGurk, University of Pennsylvania).

PARP-Inhibitors Reduce Damage in Some Neurological Disorders

A recent study found that blocking the activity of the poly(ADP-ribose)polymerase (PARP) family of enzymes reduced the amount of harmful TDP-43 (transactive response DNA binding protein) structures in brain cells under stress and slowed or prevented development of cytoplasmic inclusions found in neurological disorders such as amyotrophic lateral sclerosis (ALS), and some forms of frontotemporal degeneration (FTD). More...
20 Aug 2018
Image: Gene therapy treated airway stem cells (Photo courtesy of Dr. Nigel Farrow, University of Adelaide).

Preconditioning Enhances Stem Cell Transplantation in CF Model

Disruption of the epithelial cell layer using the agent polidocanol was found to facilitate effective transplantation of cultured stem cells into nasal airways in a mouse model of cystic fibrosis. More...
15 Aug 2018
Image: Red blood cells can safely transport nanoscale drug carriers to chosen organs by targeted placement of intravascular catheters (Photo courtesy of the University of Pennsylvania).

RBC Transporters Used for Targeting Nanoparticle Drug Carriers

A novel, patent pending nanoparticle drug delivery system uses red blood cells to transport drug carriers directly to selected target organs with minimal exposure to other areas of the body. More...
14 Aug 2018
Image: An illustration showing the protein cas12a bound to a DNA helix (red and white) (Photo courtesy of T. Yamano and H. Nishimasu / James Rybarski).

CRISPR Variant Enables More Accurate Genome Editing

Results of a recent study suggested that inherent binding properties of the Cas12a enzyme make it a better choice for gene editing purposes than the currently used CRISPR/Cas9 combination. More...
13 Aug 2018
Image: The figure shows two views, frontal and lateral, of the image obtained by CT of the lungs of a mouse with fibrosis (grey areas) before and after receiving nano-therapy directed at senescent cells (Photo courtesy of Guillem Garaulet and Francisca Mulero, Institute for Research in Biomedicine).

Gel Encapsulation Transport System Targets Disease-Related Cells

A novel therapeutic approach uses drugs encapsulated within galacto‐oligosaccharide gel capsules to target diseases that have accumulated a high percentage of senescent cells. More...
10 Aug 2018
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BioResearch brings the latest research news on the genome, proteome, metabolome, on drug discovery, and therapeutics. Biotech researchers, lab administrators, technologists, drug manufacturers, and suppliers can find the latest research news and information related to their fields of endeavor here.
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