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BioResearch

Disrupted Micronuclei Cited as Potential Non-Small-Cell Lung Cancer Biomarkers

Cancer researchers have found that collapse of the nuclear membrane that surrounds micronuclei may allow these damaged segments of DNA to reenter the cell's genetic material with possible cancer-causing consequences. More...
16 Jul 2013
Image: Agar/PAM DN hydrogels show extraordinary mechanical and free-shapeable properties: (a) bending; (b) knotting; (c) compression; (d) (stretching); (e) hexagon; (f) teddy bear gel under compression; and (g) teddy bear gel after force release (Photo courtesy of Qiang Chen and Chao Zhao).

Hydrogels Assessed for Biomedical Uses

Scientists are studying hydrogel, a hydrophilic polymer chain with similar flexibility to natural tissue, for new biomedical uses. More...
16 Jul 2013
Image: Structures of the adenovirus proteinase in inactive form (turquoise) and activated (yellow) by binding of a cofactor (beige), in association with a promising inhibitor compound identified in this research (circular "ball and stick" molecule). In the inactive form, left, the inhibitor blocks the "pocket" into which the cofactor binds, thus preventing the enzyme from becoming active. In the fully activated enzyme, right, the inhibitor binds in the now-exposed protein-cleaving "active site," thus blocking the enzyme's protein-cleaving ability. The fact that this inhibitor works to disable the proteinase in two different ways at two different sites increases the chance that drugs based on this compound will be successful at fighting adenovirus infection. It also makes it less likely that adenovirus will develop resistance to such drugs (Photo courtesy of Brookhaven National Laboratory).

Computational Modeling Yields Potential Anti-Adenovirus Drugs

Advanced computational modeling was used to identify drug candidates capable of preventing replication of all serotypes of adenovirus. More...
15 Jul 2013
Image: Molecular structures of amyloid oligomers and amyloid fibers (Photo courtesy of the University of California, Los Angeles).

Analysis Reveals Detailed Structural Features of Amyloid Oligomers

Advanced analytical analysis of amyloid-beta42 oligomers has yielded insights into the structure of these oligomers that helps to explain the mechanism behind the process of oligomerization and the reasons for their molecular toxicity. More...
15 Jul 2013

Human Clinical Trial Shows Stem Cell Therapy Hastens Bone Repair

Treatment of fractures of the pelvic bones with stem cells halved recovery time in a clinical study conducted over the past four years. More...
11 Jul 2013

Sialyltransferase Initiates New Line of Sugar-Modifying Enzymes

The first in a line of recombinant enzymes for the in vitro sialylation of glycoproteins and other macromolecules is now available for biotech researchers. More...
11 Jul 2013
Image: Neurons in the basal ganglia (Photo courtesy of Anatol Kreitzer, PhD, Gladstone Institutes).

Tracing Technique Untangles Brain Circuit Networks

High-resolution mapping has uncovered the architecture of neural circuits leading to the basal ganglia, which could promote research into disorders such as Parkinson’s disease and Huntington’s disease. More...
09 Jul 2013
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BioResearch brings the latest research news on the genome, proteome, metabolome, on drug discovery, and therapeutics. Biotech researchers, lab administrators, technologists, drug manufacturers, and suppliers can find the latest research news and information related to their fields of endeavor here.