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BioResearch

Image: A microscopic image of erythroblasts which are the bone marrow cells that secrete erythroferrone (Photo courtesy of UCLA - University of California, Los Angeles).

Erythroferrone Frees Up Iron for Red Blood Cell Production by Inhibiting Hepcidin

A recent paper outlined a novel biochemical pathway in the bone marrow that regulates the increase production of red blood cells that are required following blood loss due to hemorrhage or anemia.  More...
11 Jun 2014
Image: No bigger than a soda can, the small-scale incubator microscope is a space-saving and cost effective solution for time-lapse observation of cell cultures (Photo courtesy of Fraunhofer IBMT).

Small-Scale Incubator Microscope Designed to Study Cells in Time Lapse

German scientists have now devised innovative technology that combines the functions of both incubators and microscopes in a compact small-scale system.   More...
11 Jun 2014
Image: Remaking an artificial enzyme pair in the test tube and having it work outside the cell is a big challenge for DNA nanotechnology. To meet the challenge, they first made a DNA scaffold that looks like several paper towel rolls glued together. Using a computer program, they were able to customize the chemical building blocks of the DNA sequence so that the scaffold would self-assemble. Next, the two enzymes were attached to the ends of the DNA tubes. In the middle of the DNA scaffold, they affixed a single strand of DNA, with the NAD+ tethered to the end like a ball and string. Yan refers to this as a swinging arm, which is long, flexible and dexterous enough to rock back and forth between the enzymes (Photo courtesy of the Biodesign Institute at ASU).

DNA Nanotechnology Strategy Puts Enzyme Catalysis Within Reach

Using molecules of DNA in an architectural scaffold, scientists have developed a 3D synthetic enzyme cascade that mimics an important biochemical pathway that could prove important for future biomedical and energy applications.  More...
10 Jun 2014

Drug-Target Database and Algorithm Help Match Old Drugs to New Uses

A new database is helping scientists match existing drugs to genetic targets in new diseases.   More...
10 Jun 2014
Image: Electron micrograph shows a cancer cell (upper darker area) that has formed three invadopodia that are penetrating the adjacent extracellular matrix (lower lighter area) (Photo courtesy of Yeshiva University).

Rac1 Levels Linked to Mechanics of Invadopodia Formation and Metastasis

Cancer researchers have linked increases and decreases in the level of Rac1 protein to the appearance and disappearance of invadopodia, amoeboid-like protrusions used by metastatic cancer cells to invade neighboring tissues.  More...
09 Jun 2014
Image: Normal ECG/EKG complex with labels (Photo courtesy of Wikimedia Commons).

Area of Noncoding DNA Regulates Activity of Heartbeat Control Protein

Variants in a stretch of DNA not used by the genome for coding proteins have been linked to changes in the way the heart beats and may be linked to the risk of sudden cardiac death.   More...
09 Jun 2014
Image: Early tests of the “nanodaisy” drug delivery technique show promise against a number of cancers (Photo courtesy of Ran Mo).

“Nanodaisies” Designed to Transport Drug Cocktail to Cancer Cells

The researchers are from the joint biomedical engineering program at North Carolina State University and the University of North Carolina at Chapel Hill.   More...
09 Jun 2014
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BioResearch brings the latest research news on the genome, proteome, metabolome, on drug discovery, and therapeutics. Biotech researchers, lab administrators, technologists, drug manufacturers, and suppliers can find the latest research news and information related to their fields of endeavor here.
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