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BioResearch

“Softer” Mass Spec Techniques Gain Advantage in Biomarker Discovery

Two mass spectrometry technologies, MALDI and DESI, are increasing in applications as their effectiveness is established, according to Kalorama Information in its report “Proteomics Markets for Research and IVD Applications - Mass Spectrometry, Chromatography, Microarrays, Electrophoresis, Immunoassays, Other Technologies.”  More...
29 Mar 2015
Image: The photo shows a mouse pancreatic islet as seen by light microscopy. Beta cells can be recognized by the green insulin staining. Glucagon is labeled in red and the nuclei in blue (Photo courtesy of Wikimedia Commons).

Regenerative Potential Is a Trait of Mature Tissues, Not an Innate Feature of Newly Born Cells

Diabetes researchers have found that the ability of insulin-producing beta cells to replicate and respond to elevated glucose concentrations is absent in very young animals and does not appear until after weaning.  More...
25 Mar 2015
Image: Comparing sections of cortex from a control mouse (left) to a mouse with a presenilin-1 mutation (right). The dashed line indicates the surface of the brain. Presenilin-1 mutations decrease gamma-secretase activity and cause features of neurodegeneration, including shrinkage of the cortex, as shown above (Photo courtesy of Dr. Raymond Kelleher and Dr. Jie Shen, Harvard Medical School).

Presenilin Gene Mutation Linked to Familial form of Alzheimer's Disease

Results obtained in studies using a genetically engineered mouse model of hereditary Alzheimer's disease pointed to the importance of reduced gamma-secretase activity caused by a mutation in the presenilin gene.  More...
24 Mar 2015

The Captureseq Technique Is More Accurate for Low Expressing Genes and Long Non-Coding RNAs

The powerful new CaptureSeq technique for gene analysis was shown to be superior for detecting and quantifying genes with low expression while showing little technical variation and accurately measured differential expression of long non-coding RNAs.  More...
24 Mar 2015
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New Electronic Pipette Simplifies Liquid Handling Tasks

A new generation of electronic pipettes was designed to make routine liquid handling tasks easier for biotechnology and other life science laboratory workers.  More...
23 Mar 2015
Image: Wafers like the one shown here are used to create “organ-on-a-chip” devices to model human tissue (Photo courtesy of Dr. Anurag Mathur, University of California, Berkeley).

Human Heart-on-a-Chip Cultures May Replace Animal Models for Drug Development and Safety Screening

Human heart cells growing in an easily monitored silicon chip culture system may one day replace animal-based model systems for drug development and safety screening.  More...
22 Mar 2015
Image: The 3D Cell Explorer microscope body (Photo courtesy of Nanolive).

System for 3-D Live Cell Microscopy to Be Available Soon

An exciting breakthrough in live cell microscopy will soon be available to biotech and other life scientists in the form of a new microscope that is to be marketed by a Swiss startup company.  More...
18 Mar 2015
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BioResearch brings the latest research news on the genome, proteome, metabolome, on drug discovery, and therapeutics. Biotech researchers, lab administrators, technologists, drug manufacturers, and suppliers can find the latest research news and information related to their fields of endeavor here.